Abstract:
:We investigated the neural systems that support number processing in a patient (JL) who had damage to the left ventral occipito-temporal cortex (LvOT). JL had severely impaired written word recognition but he was remarkably accurate in number tasks, albeit slower than normal. This suggests LvOT activation is necessary for efficient but not for accurate number decisions. Here we investigated how JL made accurate number decisions using fMRI; we compared JL's brain activation to that in healthy controls and in two patients with frontal lobe damage who, like JL, made slow but accurate responses in number tasks. For semantic relative to perceptual decisions on numbers, JL did not activate the left occipito-temporal area that was involved in all other subjects. However, JL had significantly increased activation in a left posterior middle temporal region. In addition, during semantic and perceptual decisions on numbers, JL showed increased activation in: (1) the right occipito-temporal cortex, (2) right caudate, and (3) bilateral frontal regions. These effects were unique to JL and cannot be explained in terms of abnormally long response times because they were not observed in the other patients who made slow but accurate number decisions. Together these results show that although the LvOT usually contributes to efficient number processing, activation in this region is not essential for accurate performance because (i) perceptual processing of numbers can be supported by right occipital, right caudate, and bilateral frontal activation and (ii) semantic processing of numbers can be supported by increased left posterior middle temporal activation associated with hand actions.
journal_name
Neurocasejournal_title
Neurocaseauthors
Cappelletti M,Leff AP,Price CJdoi
10.1080/13554794.2011.588179subject
Has Abstractpub_date
2012-01-01 00:00:00pages
271-85issue
4eissn
1355-4794issn
1465-3656journal_volume
18pub_type
杂志文章相关文献
NEUROCASE文献大全abstract::Neurodegenerative diseases are caused by aggregation of specific proteins that catalyze a cascade of changes that ultimately lead to neurodegeneration. This concept guides current diagnostic approaches, as well as clinical trials, that focus on detecting or removing amyloid or tau from the brain. The semantic variant ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2018.1447134
更新日期:2018-04-01 00:00:00
abstract::A case report is presented detailing the successful use of awake intraoperative memory testing while using white matter stimulation in order to isolate the fornix tracks involved in memory function. The identification of the white matter tracks of the fornix that were involved in memory function was used to tailor the...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2010.547509
更新日期:2012-02-01 00:00:00
abstract::Metamemory is a multifaceted concept, which deals with an individual's knowledge and control of his or her own memory system. The ability to monitor memory performance accurately was examined in 16 patients with Alzheimer's disease (AD), 6 patients with frontotemporal lobe dementia (FTD) and 16 elderly subjects. Parti...
journal_title:Neurocase
pub_type: 临床试验,杂志文章
doi:10.1076/neur.9.6.482.29376
更新日期:2003-12-01 00:00:00
abstract::Chediak-Higashi syndrome (CHS) is a rare autosomal disorder characterized by immunodeficiency, albinism, and progressive neurologic abnormalities. While survivors of the childhood-onset disease are known to exhibit learning disabilities and neuropsychiatric disorders followed by middle-age dementia, we lack detailed d...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2020.1856384
更新日期:2020-12-09 00:00:00
abstract::With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial dam...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2018.1539501
更新日期:2018-08-01 00:00:00
abstract::We characterized the effect of virtual visual feedback (VVF) on supernumerary phantom limb pain (SPLP) in a patient with high cervical cord injury. The subject was a 22-year-old man diagnosed with complete spinal cord injury (level C2) approximately 5 years ago. We applied the ABA'B' single-case design and set phases ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2015.1011664
更新日期:2015-01-01 00:00:00
abstract::We have seen a patient with a profound, isolated, and quite selective deficit in proverb interpretation-aproverbia. The patient presented to us after an anoxic brain injury with aproverbia. Interestingly, the aproverbia appeared to be premorbid to the presenting event. Furthermore, the patient had no brain lesion that...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2016.1139728
更新日期:2016-06-01 00:00:00
abstract::Psychiatric disorders represent common comorbidities in epileptic patients. Sometimes anxiety is part of the ictal semiology, especially during seizures arising from/involving frontal or temporal lobes. We describe a patient with focal epilepsy and recurrent hyperkinetic seizures who also presented prolonged episodes ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2020.1741647
更新日期:2020-04-01 00:00:00
abstract::It has been suggested that formal thought disorder, the incoherent speech of schizophrenia, may involve a language disturbance among other abnormalities, or even be a form of dysphasia. Six patients with and seven without formal thought disorder were evaluated on an aphasia test battery. Spontaneous speech was also an...
journal_title:Neurocase
pub_type: 临床试验,杂志文章
doi:10.1093/neucas/8.3.233
更新日期:2002-01-01 00:00:00
abstract::According to Liepmann, patients with limb-kinetic apraxia (LKA) have a loss of upper limb deftness-dexterity. Prior studies have revealed in right-handed patients that, whereas injury of the left hemisphere induces an ipsilesional LKA, injury to the right hemisphere does not induce an ipsilesional LKA. There are at le...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.826683
更新日期:2014-01-01 00:00:00
abstract::Previous studies on visual form agnosic patients have shown that their color perception is relatively preserved when monochromatic figures are used. However, it is unclear whether their color perception remains normal when figures are composed of two parts in different colors. The results showed that patient X.F. had ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790701851569
更新日期:2007-10-01 00:00:00
abstract::The concreteness effect occurs in both normal and language-disordered populations. Research suggests that abstract and concrete concepts elicit differing neural activation patterns in healthy young adults, but this is undocumented in persons with aphasia (PWA). Three PWA and three age-matched controls were scanned usi...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.770881
更新日期:2014-08-01 00:00:00
abstract::We investigated the nature of covertly processed visual elements in a patient with simultanagnosia, a disorder characterized by the inability to perceive multiple aspects of a visual scene all at once. Using the first letter of the color words red, green, or blue, we created a novel testing paradigm that combined Navo...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2015.1137949
更新日期:2016-06-01 00:00:00
abstract::A 57-year-old male with no family history was diagnosed with semantic dementia. He also showed some unusual cognitive features such as episodic memory and executive dysfunctions, spatial disorientation, and dyscalculia. Rapidly progressive cognitive and physical decline occurred. About 1.5 years later, he developed cl...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.841953
更新日期:2015-02-01 00:00:00
abstract::One typical feature of the neglect syndrome in patients with right hemisphere damage is that they bisect horizontal lines to the right of centre. It has been argued that to a large extent these bisection errors can be attributed to a perceptual change whereby the patient experiences the left half of a line as shorter ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1076/neur.7.5.391.16246
更新日期:2001-01-01 00:00:00
abstract::Monocular patching might improve perceptual-attentional, not motor-intentional deficits in a patient with chronic post-stroke left spatial neglect. Performing a line-cancellation task, his omission errors were associated with a perceptual-attentional 'where' deficit, while perseverative errors were associated with 'ai...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790902776888
更新日期:2009-08-01 00:00:00
abstract::After a stroke involving the left occipitotemporal cortex our patient shows a word-length effect and has problems to identify letters or numbers in strings of symbols. But he is normal in identifying isolated letters and in non-verbally categorizing even complex images such as faces or natural scenes. His cortical les...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2019.1634739
更新日期:2019-10-01 00:00:00
abstract::We studied reading performance for words and for isolated letters in a pure alexic patient. She performed reasonably well when naming isolated letters but was slower in reading letters than a control subject when reaction times (RTs) were recorded. When the patient read isolated letters, RTs were slower for a subset o...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1076/neur.9.2.164.15069
更新日期:2003-04-01 00:00:00
abstract::We hypothesized that distinct acute right hemisphere lesions disrupt separate components of valuation and emotional response to winning and losing money and of emotional empathy in observing a partner win or lose money. We measured skin conductance response (SCR) and ratings of emotions when acute right hemisphere str...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2017.1296578
更新日期:2017-02-01 00:00:00
abstract::This paper reports the case of a patient, M.P., who developed delusion of inanimate doubles, without Capgras syndrome, after traumatic brain injury. His delusional symptoms were studied longitudinally and the cognitive impairments associated with delusion were investigated. Data suggest that M.P. did 'perceive' the ac...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2011.627344
更新日期:2012-01-01 00:00:00
abstract::Vocal emblems, such as shh and brr, are speech sounds that have linguistic and nonlinguistic features; thus, it is unclear how they are processed in the brain. Five adult dextral individuals with left-brain damage and moderate-severe Wernicke's aphasia, five adult dextral individuals with right-brain damage, and five ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2012.667122
更新日期:2013-01-01 00:00:00
abstract::Well-organized somatotopic representation of the hand is required to interpret input from cutaneous mechanoreceptors. Previous reports have identified patients with various distortions of somatotopic representation after stroke. Importantly, those patients were investigated years after the stroke, indicating that affe...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2015.1046886
更新日期:2016-01-01 00:00:00
abstract::Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a give...
journal_title:Neurocase
pub_type: 临床试验,杂志文章
doi:10.1080/13554790701595471
更新日期:2007-08-01 00:00:00
abstract::A current debate in the literature is whether all declarative memories and associated memory processes rely on the same neural substrate. Here, we show that H.C., a developmental amnesic person with selective bilateral hippocampal volume loss, has a mild deficit in personal episodic memory, and a more pronounced defic...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2010.532138
更新日期:2011-10-01 00:00:00
abstract::Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2011.627341
更新日期:2012-01-01 00:00:00
abstract::Studies of patients with brain lesions have demonstrated that language and praxis are mediated by dissociable networks. However, language has the capacity to influence the selection of purposeful actions. The abilities to use language and to program purposeful movements are often mediated by networks that have anatomi...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.770883
更新日期:2014-06-01 00:00:00
abstract::Oculocutaneous albinism (OCA) is a group of autosomal recessive disorders characterized by impairment in the melanin synthesis. We report two siblings with OCA who presented with symptoms of autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). Ocular side effects occured after methylphenidate ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2020.1853174
更新日期:2020-12-01 00:00:00
abstract::A 51-year-old right-handed man developed hypersexuality after a second right temporal lobectomy to treat epilepsy. His hypersexuality started with increased marital intercourse and masturbation but he later downloaded child pornography. Hyperphagia and distractibility, other features of the Kluver-Bucy syndrome, also ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790903329182
更新日期:2010-04-01 00:00:00
abstract::The psychoses of epilepsy are well recognized complications of seizure disorders, diagnosed easily from the history. However, in the absence of recognized seizures, the diagnosis can be challenging. We present a 27-year-old female, who suffered a treatment refractory psychosis for 6 years. She did not report, or dis...
journal_title:Neurocase
pub_type: 杂志文章,评审
doi:10.1080/13554794.2011.627338
更新日期:2012-01-01 00:00:00
abstract::The amygdala nuclei appear to be critically implicated in emotional memory. However, in most studies, encoding and consolidation processes cannot be analyzed separately. We thus studied the verbal emotional memory in a young woman with a ganglioglioma of the left amygdala and analyzed its impact (1) on each step of th...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2015.1037843
更新日期:2016-01-01 00:00:00