Abstract:
:In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm that ketanserin acts as a mild bronchodilator in patients with COPD and demonstrate that the inhaled route has no advantage over the intravenous route in terms of effectiveness. Thus, 5-HT may play a role in bronchomotor tone, at least in patients with chronic airway obstruction.
journal_name
Chestjournal_title
Chestauthors
Cazzola M,Guidetti E,Sepe J,Assogna G,Lucchetti G,Santangelo G,D'Amato Gdoi
10.1378/chest.97.4.901subject
Has Abstractpub_date
1990-04-01 00:00:00pages
901-5issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)35060-7journal_volume
97pub_type
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