Acute respiratory and cardiovascular effects of inhaled ketanserin in chronic obstructive pulmonary disease. A comparative study with intravenously administered ketanserin.

Abstract:

:In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm that ketanserin acts as a mild bronchodilator in patients with COPD and demonstrate that the inhaled route has no advantage over the intravenous route in terms of effectiveness. Thus, 5-HT may play a role in bronchomotor tone, at least in patients with chronic airway obstruction.

journal_name

Chest

journal_title

Chest

authors

Cazzola M,Guidetti E,Sepe J,Assogna G,Lucchetti G,Santangelo G,D'Amato G

doi

10.1378/chest.97.4.901

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

901-5

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)35060-7

journal_volume

97

pub_type

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