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Resting cardiac energy metabolism is inversely associated with heart rate in healthy young adult men.

Abstract：

BACKGROUND:31-Phosphorus-magnetic resonance spectroscopy may provide pathophysiological insights into the high-energy phosphate metabolism of the myocardium as measured by phosphocreatine to adenosine triphosphate (PCr/ATP) ratio. Aim of the present study was to determine in vivo the relation between cardiac PCr/ATP ratio and heart rate in normal male subjects. METHODS:One hundred twelve apparently healthy, young male individuals (age 34 ± 10 years) were prospectively evaluated. They underwent cardiac cine magnetic resonance imaging to assess left ventricular (LV) function and morphology and 3D-ISIS (31)P-magnetic resonance spectroscopy of the LV to assess the PCr/ATP ratio (a recognized in vivo marker of myocardial energy metabolism). Data were analyzed after segregation by tertiles of the resting PCr/ATP ratio. RESULTS:A significant inverse association between PCr/ATP ratios and resting heart rate was observed (Spearman ρ: r=-0.37; P < .0001). PCr/ATP ratios were also inversely associated with body mass index, diastolic blood pressure, wall mass and with insulin resistance, but in multiple regression analysis heart rate was found to be independently related to PCr/ATP. CONCLUSIONS:The present study shows that resting heart rate is proportionally lower across tertiles of increasing PCr/ATP ratio of the LV in apparently healthy young male individuals, supporting the hypothesis that heart rate is a major determinant of cardiac energy stores. These findings may explain the prognostic role of heart rate in the general population as evidenced by previous large epidemiological studies.

journal_name

Am Heart J

journal_title

American heart journal

authors

Fragasso G,De Cobelli F,Spoladore R,Esposito A,Salerno A,Calori G,Montanaro C,Maranta F,Lattuada G,Margonato A,Del Maschio A,Perseghin G

doi

10.1016/j.ahj.2011.04.012

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

136-41

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(11)00278-X

journal_volume

162

pub_type

杂志文章

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