Spinal opioids in adult patients with cancer pain: a systematic review: a European Palliative Care Research Collaborative (EPCRC) opioid guidelines project.

Abstract:

BACKGROUND:A systematic review, undertaken according to an initiative to revise European Association for Palliative Care guidelines on the use of opioids for cancer pain, which aimed to analyse analgesic efficacy and side effects of spinal opioids in adult cancer patients previously treated with systemic opioids. METHODS:Search strategy elaborated with MeSH terms and words related to cancer, palliative care, pain, spinal route and opioids. PubMed, Embase and Cochrane assessed in Nov 2009. Studies were analysed and classified according to quality of evidence and strength of recommendation. RESULTS:Out of 2939 abstracts, 44 articles were selected (nine randomized controlled trials (RCTs), two non-randomized cohort studies, 28 uncontrolled prospective studies, and five case series). Relief of pain and/or side effects were reported in 42 articles; however, there were few studies of high quality design (RCTs) and these studies had methodological limitations that reduced their quality of evidence to very low. CONCLUSION:There are few RCTs and these are of very low quality. As a result, they provide weak recommendation for using spinal opioids in adult cancer patients. Further studies are clearly needed.

journal_name

Palliat Med

journal_title

Palliative medicine

authors

Kurita GP,Kaasa S,Sjøgren P,European Palliative Care Research Collaborative (EPCRC).

doi

10.1177/0269216310386279

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

560-77

issue

5

eissn

0269-2163

issn

1477-030X

pii

25/5/560

journal_volume

25

pub_type

杂志文章,评审
  • French general practitioners vary in their attitudes toward treating terminally ill patients.

    abstract::The purpose of this study is to analyze French general practitioners' attitudes toward prescribing opiate painkillers for dying patients and compare them with their attitudes toward making frequent home visits. One hundred and fifteen general practitioners indicated the acceptability of prescribing opiates in 48 scena...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216309107012

    authors: Mas C,Albaret MC,Sorum PC,Mullet E

    更新日期:2010-01-01 00:00:00

  • Good end-of-life care in nursing home according to the family carers' perspective: A systematic review of qualitative findings.

    abstract:BACKGROUND:Nursing homes are becoming a common site where delivering end-of-life care for older adults. They often represent the junction between the curative and the palliative phase. AIM:To identify the elements that nursing home residents' family carers perceive as good end-of-life care and develop a conceptual mod...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216319840275

    authors: Gonella S,Basso I,De Marinis MG,Campagna S,Di Giulio P

    更新日期:2019-06-01 00:00:00

  • A self-care, problem-solving and mindfulness intervention for informal caregivers of people with motor neurone disease: A pilot study.

    abstract:BACKGROUND:Informal caregivers of people with motor neurone disease (MND) take on an extensive role. Caregivers are at increased risk of experiencing psychological distress and burden, yet, there is a lack of intervention programmes to support them. AIM:The aim of this study was to investigate the feasibility and acce...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216317743434

    authors: Ugalde A,Mathers S,Hennessy Anderson N,Hudson P,Orellana L,Gluyas C

    更新日期:2018-04-01 00:00:00

  • Barriers to achieving care at home at the end of life: transferring patients between care settings using patient transport services.

    abstract::Enabling patients to be cared for in their preferred location often involves journeys between care settings. The challenge of ensuring journeys are timely and safe emerged as an important issue in an evaluation of palliative care services, which informed a service redesign programme in three areas of the United Kingdo...

    journal_title:Palliative medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0269216309106893

    authors: Ingleton C,Payne S,Sargeant A,Seymour J

    更新日期:2009-12-01 00:00:00

  • Systematic review of barriers and enablers to the delivery of palliative care by primary care practitioners.

    abstract:BACKGROUND:There is increasing demand for primary care practitioners to play a key role in palliative care delivery. Given this, it is important to understand their perceptions of the barriers and enablers to optimal palliative care, and how commonly these are experienced. AIM:To explore the type and prevalence of bar...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216319865414

    authors: Carey ML,Zucca AC,Freund MA,Bryant J,Herrmann A,Roberts BJ

    更新日期:2019-10-01 00:00:00

  • The preferred priorities for care document in motor neurone disease: views of bereaved relatives and carers.

    abstract::Increasing emphasis is being placed on the need for advanced care planning (ACP) at the end of life. The Preferred Priorities for Care (PPC) document is a patient-held record promoted by the End of Life Care Strategy as an ACP tool to promote discussion and communication amongst patients, family and health care provid...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216311399664

    authors: Preston H,Fineberg IC,Callagher P,Mitchell DJ

    更新日期:2012-03-01 00:00:00

  • Legacy perceptions and interventions for adults and children receiving palliative care: A systematic review.

    abstract:BACKGROUND:Legacy has been invoked as a means for strengthening human attachments, continuing bonds, and ensuring that individuals will be remembered; however, little is known about the spectrum of approaches to, outcomes associated with, and best practices for legacy interventions. AIM:To systematically review resear...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216321989565

    authors: Boles JC,Jones MT

    更新日期:2021-01-25 00:00:00

  • Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project.

    abstract:BACKGROUND:Bisphosphonates and denosumab are well-established therapies to reduce the frequency and severity of skeletal-related events in patients with bone metastasis. However, the analgesic effect of these medications on bone pain is uncertain. AIM:To identify, critically appraise and synthesize existing evidence t...

    journal_title:Palliative medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0269216316639793

    authors: Porta-Sales J,Garzón-Rodríguez C,Llorens-Torromé S,Brunelli C,Pigni A,Caraceni A

    更新日期:2017-01-01 00:00:00

  • Patients' experiences of a new integrated breathlessness support service for patients with refractory breathlessness: Results of a postal survey.

    abstract:BACKGROUND:We developed a new single point of access to integrated palliative care, respiratory medicine and physiotherapy: the breathlessness support service for patients with advanced disease and refractory breathlessness. This study aimed to describe patients' experiences of the service and identify the aspects valu...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216315600103

    authors: Reilly CC,Bausewein C,Pannell C,Moxham J,Jolley CJ,Higginson IJ

    更新日期:2016-03-01 00:00:00

  • Attitudes toward euthanasia among Swedish medical students.

    abstract::Attitudes toward euthanasia differ between individuals and populations, and in many studies the medical profession is more reluctant than the general public. Our goal was to explore medical students' attitude toward euthanasia. A questionnaire containing open-ended questions was answered anonymously by 165 first- and ...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216307081940

    authors: Karlsson M,Strang P,Milberg A

    更新日期:2007-10-01 00:00:00

  • Optimizing hospital-based home care for dying cancer patients: a population-based study.

    abstract::Health-related quality of life (HRQL) is difficult to define and measure. It is a generic term that includes concepts such as physical health, life satisfaction, psychological well-being and self-integrity. Realizing and appreciating the importance of HRQL is crucial for physicians if they are to be in a position to o...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1191/026921699669663451

    authors: Mystakidou K,Tsilika E,Befon S,Kululias V,Vlahos L

    更新日期:1999-09-01 00:00:00

  • Effectiveness of the Liverpool care pathway for the dying in residential care homes: An exploratory, controlled before-and-after study.

    abstract:BACKGROUND:Clinical pathways aim to ensure that individuals receive appropriate evidence-based care and interventions, with the Liverpool Care Pathway for the Dying Patient focusing on end of life. However, controlled studies of the Liverpool Care Pathway for the Dying Patient, particularly outside of cancer settings, ...

    journal_title:Palliative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0269216315588007

    authors: Brännström M,Fürst CJ,Tishelman C,Petzold M,Lindqvist O

    更新日期:2016-01-01 00:00:00

  • Professionally perceived effectiveness of psychosocial interventions for existential suffering of terminally ill cancer patients.

    abstract:BACKGROUND:Although integrated care for existential suffering is an essential part of palliative care, little is known about its concept and efficacy as perceived by professionals. A questionnaire survey was carried out to 1) explore the underlying structure of psychosocial interventions recommended by specialists, 2) ...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1191/0269216303pm825oa

    authors: Hirai K,Morita T,Kashiwagi T

    更新日期:2003-12-01 00:00:00

  • Illness awareness in terminal cancer patients: an Italian study.

    abstract::The amount and quality of information and awareness in cancer patients' is a topic frequently debated, but few studies have focussed on terminal patients. This is the objective of the present study that involved two different palliative home-care units in Italy, which recruited 550 terminal cancer patients. Data from ...

    journal_title:Palliative medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0269216308100772

    authors: Corli O,Apolone G,Pizzuto M,Cesaris L,Cozzolino A,Orsi L,Enterri L

    更新日期:2009-06-01 00:00:00

  • The effects of spiritual care on quality of life and spiritual well-being among patients with terminal illness: A systematic review.

    abstract:BACKGROUND:Terminal illness not only causes physical suffering but also spiritual distress. Spiritual care has been widely implemented by healthcare professionals to assist patients coping with spiritual distress. However, the effects of spiritual care need to be clear. AIM:To evaluate the effects of spiritual care on...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216318772267

    authors: Chen J,Lin Y,Yan J,Wu Y,Hu R

    更新日期:2018-07-01 00:00:00

  • Integration of acupuncture into the oncology clinic.

    abstract:PURPOSE/OBJECTIVE:Patients with cancer or symptoms referable to cancer therapy were offered acupuncture as potential palliation of their symptoms. This paper describes the physical integration of the discipline into the Oncology Clinic, and patient perspectives on its availability and efficacy. PATIENTS AND METHODS:Be...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1191/0269216302pm540oa

    authors: Johnstone PA,Polston GR,Niemtzow RC,Martin PJ

    更新日期:2002-05-01 00:00:00

  • Cost variations in ambulatory and home-based palliative care.

    abstract::Restructuring health care in Canada has emphasized the provision of ambulatory and home-based palliative care. Acquiring economic evidence is critical given this trend and its tremendous demands on family caregivers. The purposes of this study were: 1) to comprehensively assess the societal costs of home-based palliat...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216310364877

    authors: Guerriere DN,Zagorski B,Fassbender K,Masucci L,Librach L,Coyte PC

    更新日期:2010-07-01 00:00:00

  • A patient with dementia and cancer: to feed via percutaneous endoscopic gastrostomy tube or not?

    abstract::Despite the lack of clear benefits of feeding via gastrostomy tube in dementia patients, its use has been increasing. The views of health professionals, patients and their carers differ widely about the perceived benefits, which makes decision-making difficult and stressful. The palliative care approach of facilitatin...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216306071796

    authors: Shah SH

    更新日期:2006-10-01 00:00:00

  • Psychological support in end-of-life decision-making in neonatal intensive care units: Full population survey among neonatologists and neonatal nurses.

    abstract:BACKGROUND:Moral distress and burnout related to end-of-life decisions in neonates is common in neonatologists and nurses working in neonatal intensive care units. Attention to their emotional burden and psychological support in research is lacking. AIM:To evaluate perceived psychological support in relation to end-of...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216319888986

    authors: Dombrecht L,Cohen J,Cools F,Deliens L,Goossens L,Naulaers G,Beernaert K,Chambaere K,NICU consortium.

    更新日期:2020-03-01 00:00:00

  • Palliative care services: what needs assessment?

    abstract::A survey of all district health authorities in England was conducted in order to describe current patterns of needs assessment and contract setting for palliative care services. Outcome measures included the completion of needs assessments in the past five years, the type of data used for needs assessment, and recomme...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/026921639500900403

    authors: Robbins MA,Frankel SJ

    更新日期:1995-10-01 00:00:00

  • The misuse/abuse of antihistamine antiemetic medication (cyclizine) by cancer patients.

    abstract::Cyclizine is an antihistamine, which is frequently used to manage nausea and vomiting in cancer patients. Antihistamines can be drugs of misuse/abuse, and the article describes four cancer patients who developed such problems after receiving parenteral cyclizine within the inpatient unit of a cancer centre. The articl...

    journal_title:Palliative medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0269216308094337

    authors: Bailey F,Davies A

    更新日期:2008-10-01 00:00:00

  • 'Oh God, not a palliative': out-of-hours general practitioners within the domain of palliative care.

    abstract::To date, the experiences of out-of-hours general practitioners with regard to palliative care patients and their management are yet to be evaluated, since the new General Medical Services contract came into force. In 2007 the National Institute for Health Research highlighted the need to identify factors that improve ...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216310368580

    authors: Taubert M,Nelson A

    更新日期:2010-07-01 00:00:00

  • Pain scales in children: a review.

    abstract::This is a review of tools that have been developed to assess pain in children, with a brief evaluation of their practicality and validity. There are some suggestions for the direction of future research in the development and use of the scales. ...

    journal_title:Palliative medicine

    pub_type: 杂志文章,评审

    doi:10.1177/026921639701100503

    authors: Hain RD

    更新日期:1997-09-01 00:00:00

  • Euthanasia: the word and the act in palliative medicine.

    abstract::The word 'euthanasia' has been used with a variety of meanings, all of which refer to one precise action: the killing of a suffering person. A moral evaluation of such an act can lead us either to condemn it a priori, shutting the door upon any argument, or to allow further discussion. But the issue must be discussed,...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/026921639300700304

    authors: Di Mola G

    更新日期:1993-01-01 00:00:00

  • A qualitative study to explore psychological distress and illness burden associated with opioid-induced constipation in cancer patients with advanced disease.

    abstract:BACKGROUND:Constipation affects many patients receiving long-term opioid therapy for cancer pain. Little is known about the nature of psychological distress and the burden associated with this problem. This information may inform the development of effective treatment strategies and ameliorate distress. AIM:The object...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216312450358

    authors: Dhingra L,Shuk E,Grossman B,Strada A,Wald E,Portenoy A,Knotkova H,Portenoy R

    更新日期:2013-05-01 00:00:00

  • Detection of delirium in palliative care unit patients: a prospective descriptive study of the Delirium Observation Screening Scale administered by bedside nurses.

    abstract:BACKGROUND:The Delirium Observation Screening Scale (DOS) is designed to detect delirium by nurses' observations and has shown good psychometric properties. Its use in palliative care unit patients has not been studied. AIM:To determine diagnostic and concurrent validity, internal consistency, and user-friendliness of...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216313492187

    authors: Detroyer E,Clement PM,Baeten N,Pennemans M,Decruyenaere M,Vandenberghe J,Menten J,Joosten E,Milisen K

    更新日期:2014-01-01 00:00:00

  • Hospital doctors' understanding of use and withdrawal of the Liverpool Care Pathway: A qualitative study of practice-based experiences during times of change.

    abstract:BACKGROUND:The Liverpool Care Pathway was used in UK hospitals (late 1990s to July 2014) in an attempt to generate hospice-style high-quality end-of-life care in acute settings. Despite being widely established, there was limited research or contextual evidence regarding this approach or its impact. Growing criticism f...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1177/0269216316679927

    authors: Twigger S,Yardley SJ

    更新日期:2017-10-01 00:00:00

  • Clinical research in palliative care: patient populations, symptoms, interventions and endpoints.

    abstract::Clinical trials in palliative care involve multiple issues relating to patient populations, interventions and endpoints. Careful data collection and analysis of variables are vital for good clinical research in this complex area. ...

    journal_title:Palliative medicine

    pub_type: 杂志文章

    doi:10.1191/026921601668441770

    authors: Mazzocato C,Sweeney C,Bruera E

    更新日期:2001-03-01 00:00:00

  • The Nordic Specialist Course in Palliative Medicine: evaluation and experiences from the first course 2003-2005.

    abstract:BACKGROUND AND AIMS:Palliative medicine is not recognized as a medical specialty in any of the five Nordic countries, but there is a great need for physicians with specialty qualifications to serve on an increasing number of palliative care services. The Associations for Palliative Medicine in the five countries agreed...

    journal_title:Palliative medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0269216307087320

    authors: Haugen DF,Vejlgaard T

    更新日期:2008-04-01 00:00:00

  • Knowledge and information needs of informal caregivers in palliative care: a qualitative systematic review.

    abstract:OBJECTIVES:To review current understanding of the knowledge and information needs of informal caregivers in palliative settings. DATA SOURCES:Seven electronic databases were searched for the period January 1994--November 2006: Medline, CINAHL, PsychINFO, Embase, Ovid, Zetoc and Pubmed using a meta-search engine (Metal...

    journal_title:Palliative medicine

    pub_type: 杂志文章,评审

    doi:10.1177/0269216307085343

    authors: Docherty A,Owens A,Asadi-Lari M,Petchey R,Williams J,Carter YH

    更新日期:2008-03-01 00:00:00