Abstract:
:We studied the potentiation of analgesia for labour by the addition of clonidine to epidural low-concentration levobupivacaine with sufentanil in a randomised, double-blinded study. We enrolled primiparous women who were in spontaneous labour. The study solutions, made of 100 ml levobupivacaine 0.0625% plus sufentanil 0.45 μg.ml(-1) and either 150 μg clonidine or no clonidine, were used for induction of analgesia, and for its maintenance with self-administered boluses and a continuous background infusion. The need for additional epidural boluses during labour was lower and analgesia and maternal satisfaction were better in the clonidine (n = 57) than in the control group (n = 58). Blood pressure was lower and the rate of instrumental delivery higher in the clonidine group. Clonidine (1.36 μg.ml(-1)) added to the epidural solution of low-concentration levobupivacaine improves the quality of analgesia. The relevance of the haemodynamic effects should be explored in larger validation studies.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Bazin M,Bonnin M,Storme B,Bolandard F,Vernis L,Lavergne B,Pereira B,Bazin JE,Dualé Cdoi
10.1111/j.1365-2044.2011.06785.xsubject
Has Abstractpub_date
2011-09-01 00:00:00pages
769-79issue
9eissn
0003-2409issn
1365-2044journal_volume
66pub_type
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