Addition of clonidine to a continuous patient-controlled epidural infusion of low-concentration levobupivacaine plus sufentanil in primiparous women during labour.

Abstract:

:We studied the potentiation of analgesia for labour by the addition of clonidine to epidural low-concentration levobupivacaine with sufentanil in a randomised, double-blinded study. We enrolled primiparous women who were in spontaneous labour. The study solutions, made of 100 ml levobupivacaine 0.0625% plus sufentanil 0.45 μg.ml(-1) and either 150 μg clonidine or no clonidine, were used for induction of analgesia, and for its maintenance with self-administered boluses and a continuous background infusion. The need for additional epidural boluses during labour was lower and analgesia and maternal satisfaction were better in the clonidine (n = 57) than in the control group (n = 58). Blood pressure was lower and the rate of instrumental delivery higher in the clonidine group. Clonidine (1.36 μg.ml(-1)) added to the epidural solution of low-concentration levobupivacaine improves the quality of analgesia. The relevance of the haemodynamic effects should be explored in larger validation studies.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Bazin M,Bonnin M,Storme B,Bolandard F,Vernis L,Lavergne B,Pereira B,Bazin JE,Dualé C

doi

10.1111/j.1365-2044.2011.06785.x

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

769-79

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

66

pub_type

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