Cerebral and regional organ perfusion in pigs during xenon anaesthesia.

Abstract:

:Little is known about the haemodynamic effects of inhaled xenon on regional organ perfusion. The aim of this study was to investigate the effect of 79% xenon ventilation on organ perfusion in pigs. We investigated 10 pigs, which were randomly allocated to receive either xenon 79% or total intravenous anaesthesia (TIVA)/oxygen anaesthesia. Microspheres were used to determine organ perfusion. The following regions of interest were investigated: cerebral cortex, medulla oblongata, brainstem, cerebellum, liver, kidney, small intestine, colon, muscle, skin and heart. The results demonstrated a significant increase in regional perfusion in the brainstem (+63%), cerebral cortex (+38%), medulla oblongata (+35%) and cerebellum (+34%). All other organs showed no significant change in regional perfusion. We conclude that xenon should be used with caution in clinical situations associated with pathological increases in intracranial pressure, e.g. neurosurgical procedures, head injury, cerebral mass lesions or stroke.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Schmidt M,Marx T,Kotzerke J,Lüderwald S,Armbruster S,Topalidis P,Schirmer U,Reinelt H

doi

10.1046/j.1365-2044.2001.02322.x

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1154-9

issue

12

eissn

0003-2409

issn

1365-2044

pii

2322

journal_volume

56

pub_type

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