Elevated expression of v-mos is correlated with altered differentiation of carcinoma cells.

abstract：:Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally ...

journal_title：Oncogene

authors： Liu-Chittenden Y,Jain M,Gaskins K,Wang S,Merino MJ,Kotian S,Kumar Gara S,Davis S,Zhang L,Kebebew E

更新日期：2017-06-22 00:00:00

abstract：:Despite the recent success of MAPK signaling-targeted drugs in melanoma, the majority of patients with metastatic melanoma still undergo disease progression after initial tumor shrinkage indicating gradually developing therapy resistance. This review will give an overview on currently suggested concepts of resistance ...

journal_title：Oncogene

authors： Roesch A

更新日期：2015-06-04 00:00:00

abstract：:BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The pr...

journal_title：Oncogene

authors： Titz B,Low T,Komisopoulou E,Chen SS,Rubbi L,Graeber TG

更新日期：2010-11-04 00:00:00

abstract：:Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that encodes a 26 kDa GTP-binding protein with high homology to Ras and Rap. Unlike other Ras family members, ARHI exhibits several unusual structural and functional properties. ARHI contains a unique 34 amino...

journal_title：Oncogene

authors： Luo RZ,Fang X,Marquez R,Liu SY,Mills GB,Liao WS,Yu Y,Bast RC

更新日期：2003-05-15 00:00:00

abstract：:14-3-3sigma proteins regulate numerous cellular processes that are important to cancer development. One of its biological roles involves G2 cell-cycle arrest following DNA damage. It has also been reported that the loss of 14-3-3sigma expression via CpG methylation may contribute to malignant transformation by impairi...

journal_title：Oncogene

authors： Pulukuri SM,Rao JS

更新日期：2006-08-03 00:00:00

abstract：:Normal human melanocytes are interspersed singly among keratinocytes along the basement membrane of the epidermis, whereas melanoma cells readily adhere to each other during invasion of the dermis or distant organs. The tumorigenic and metastatic phenotype of melanoma cells often correlates with increased expression o...

journal_title：Oncogene

authors： Satyamoorthy K,Muyrers J,Meier F,Patel D,Herlyn M

更新日期：2001-08-02 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and i...

journal_title：Oncogene

authors： Jungnickel C,Schmidt LH,Bittigkoffer L,Wolf L,Wolf A,Ritzmann F,Kamyschnikow A,Herr C,Menger MD,Spieker T,Wiewrodt R,Bals R,Beisswenger C

更新日期：2017-07-20 00:00:00

abstract：:KLF6, a ubiquitously expressed Krüppel-like transcription factor, is frequently inactivated in human cancer and has significant roles in cellular proliferation, apoptosis, differentiation and development. A key mechanism of KLF6-mediated growth suppression is through p53-independent transactivation of p21. Several can...

journal_title：Oncogene

authors： Lang UE,Kocabayoglu P,Cheng GZ,Ghiassi-Nejad Z,Muñoz U,Vetter D,Eckstein DA,Hannivoort RA,Walsh MJ,Friedman SL

更新日期：2013-09-19 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunoprecipitation of fusion protein or in vitro translated protein, respect...

journal_title：Oncogene

authors： Drané P,Barel M,Balbo M,Frade R

更新日期：1997-12-18 00:00:00

abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...

journal_title：Oncogene

authors： Oricchio E,Sciamanna I,Beraldi R,Tolstonog GV,Schumann GG,Spadafora C

更新日期：2007-06-21 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

journal_title：Oncogene

authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

更新日期：2019-03-01 00:00:00

abstract：:SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...

journal_title：Oncogene

authors： Zhang L,Xu Z,Xu X,Zhang B,Wu H,Wang M,Zhang X,Yang T,Cai J,Yan Y,Mao F,Zhu W,Shao Q,Qian H,Xu W

更新日期：2014-11-27 00:00:00

abstract：:Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We set out to unco...

journal_title：Oncogene

authors： Aubry A,Pearson JD,Huang K,Livne-Bar I,Ahmad M,Jagadeesan M,Khetan V,Ketela T,Brown KR,Yu T,Lu S,Wrana JL,Moffat J,Bremner R

更新日期：2020-07-01 00:00:00

abstract：:To understand the function of the individual oncogenes of HPV16 in modulating the cellular response to apoptogenic signals, we used human keratinocytes immortalized with either E6, E7 or E6/E7 oncoproteins as model system. Applying CD95 antibodies or recombinant CD95 ligand, only the E7-immortalized cells underwent ex...

journal_title：Oncogene

authors： Aguilar-Lemarroy A,Gariglio P,Whitaker NJ,Eichhorst ST,zur Hausen H,Krammer PH,Rösl F

更新日期：2002-01-10 00:00:00

abstract：:Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known. Here we characterize structurally and functionally a rearranged NFKB2 gene identified at the T cell lymphoma line, HUT78. The rearrangement has truncated NFKB2 sequences within...

journal_title：Oncogene

authors： Zhang J,Chang CC,Lombardi L,Dalla-Favera R

更新日期：1994-07-01 00:00:00

abstract：:Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hype...

journal_title：Oncogene

authors： Meunier C,Cai J,Fortin A,Kwan T,Marquis JF,Turbide C,Van Der Kraak L,Jothy S,Beauchemin N,Gros P

更新日期：2010-02-04 00:00:00

abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

journal_title：Oncogene

authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

更新日期：1990-12-01 00:00:00

abstract：:A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. Apart from the clinical impact, this fact also suggests (1) that the SYT-SSX fusion gene may influence molecular mechanism...

journal_title：Oncogene

authors： Xie Y,Skytting B,Nilsson G,Grimer RJ,Mangham CD,Fisher C,Shipley J,Bjerkehagen B,Myklebost O,Larsson O

更新日期：2002-08-22 00:00:00

abstract：:We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the...

journal_title：Oncogene

authors： Kosaka M,Iwai SA,Nishina Y,Sumi T,Nishimune Y

更新日期：1992-12-01 00:00:00

abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

journal_title：Oncogene

authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

更新日期：2002-02-28 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...

journal_title：Oncogene

authors： al-Bagdadi F,Singh B,Arlinghaus RB

更新日期：1990-08-01 00:00:00

abstract：:Exposure of normal adult human skin to doses of UV irradiation that induced mild sunburn resulted in the rapid appearance of p53 protein in the epidermis and superficial dermal fibroblasts. Immunohistological analysis with a panel of antibodies established that while p53 staining was not seen in normal skin it appeare...

journal_title：Oncogene

authors： Hall PA,McKee PH,Menage HD,Dover R,Lane DP

更新日期：1993-01-01 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00

abstract：:Class I HLA expression is low in neuroblastoma tumours and cell lines. We have recently mapped a modifier of methylation for HLA-C (MEMO-1) to chromosomal bands 1p35-36.1, a region deleted in many neuroblastomas. Hypomethylation of HLA-C is strongly correlated with allelic loss of the MEMO-1 locus. Here, we show that ...

journal_title：Oncogene

authors： Cheng NC,Beitsma M,Chan A,Op den Camp I,Westerveld A,Pronk J,Versteeg R

更新日期：1996-10-17 00:00:00

abstract：:To investigate the effect of p33(ING1) on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33(ING1) cDNA. Infection with Ad-p53 (recombinant adenovirus containing wild-type p53) into p33-transfected cells reduced cell viability, while infection with empty vector had littl...

journal_title：Oncogene

authors： Shimada H,Liu TL,Ochiai T,Shimizu T,Haupt Y,Hamada H,Abe T,Oka M,Takiguchi M,Hiwasa T

更新日期：2002-02-14 00:00:00