Abstract:
INTRODUCTION:In unresectable intrahepatic cholangiocarcinoma (ICC), systemic chemotherapy often is viewed as the only option, although efficacy is limited. Radioembolization (RE) using yttrium-90 ((90)Y) microspheres is an accepted therapy for patients with hepatocellular-carcinoma or metastatic liver tumors. However, there are limited data on the value of RE in patients with ICC and few data on factors influencing prognosis. The purpose of our retrospective analysis was to establish which factors influenced time-to-progression (TTP) and overall survival (OS). METHODS:Patients with unresectable ICC were treated with (90)Y resin-microspheres and assessed at 3-monthly intervals. Radiologic response was evaluated by using Response Criteria in Solid Tumors (RECIST). Baseline characteristics, biochemical/clinical toxicities, and response were examined for impact on TTP and OS. RESULTS:Thirty-four treatments were administered to 33 patients without major complications. By RECIST, 12 patients had a partial response, 17 had stable disease, and 5 had progressive disease after 3 months. The median OS was 22 months posttreatment and 43.7 months postdiagnosis. Median TTP was 9.8 months. Survival and TTP were significantly prolonged in patients with ECOG 0 (vs. ECOG 1 or 2; median OS: 29.4, 10, and 5.1 months; TTP: 17.5, 6.9, and 2.4 months), tumor burden ≤25% (OS: 26.7 vs. 6 months; TTP: 17.5 vs. 2.3 months), or tumor response (PR or SD vs. PD; OS: 35.5, 17.7 vs. 5.7 months; TTP: 31.9, 9.8 vs. 2.5 months), respectively (P < 0.001). CONCLUSIONS:Radioembolization is an effective and safe option for patients with unresectable ICC. Predictors for prolonged survival are performance status, tumor burden, and RECIST response.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Hoffmann RT,Paprottka PM,Schön A,Bamberg F,Haug A,Dürr EM,Rauch B,Trumm CT,Jakobs TF,Helmberger TK,Reiser MF,Kolligs FTdoi
10.1007/s00270-011-0142-xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
105-16issue
1eissn
0174-1551issn
1432-086Xjournal_volume
35pub_type
杂志文章abstract:PURPOSE:To evaluate the efficacy of percutaneous balloon dilatation and temporary internal stenting in the treatment of transplant ureteral strictures. METHODS:Nine patients presenting with obstructed renal transplants were treated by antegrade nephrostomy insertion, ureteroplasty, and temporary internal stenting. Fol...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900412
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abstract:PURPOSE:To evaluate the clinical use of covered and noncovered, knitted nitinol stents in patients presenting new stent indications. METHODS:Self-expandable, knitted nitinol stents were implanted in four patients for treatment of dysphagia. In two patients who had malignant strictures and had esophago-respiratory fist...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::We would like to correct one of the references that was listed incorrectly in our article. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 已发布勘误
doi:10.1007/s00270-020-02668-2
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abstract::Because magnetic resonance tomography (MRT) has the ability to make cross-sectional images in three planes that have superior contrast between organs, muscle, fat, and bone, its use for the demonstration of pelvic disease shows considerable promise. The normal pelvic anatomy is clearly displayed because of the high co...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02552373
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-020-02451-3
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:1991-11-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02552673
更新日期:1984-01-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
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更新日期:2009-07-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02713-0
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02577632
更新日期:1996-11-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709910011
更新日期:2000-01-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
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更新日期:2014-06-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0241-z
更新日期:2004-09-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-007-9025-6
更新日期:2007-09-01 00:00:00