Sexual dimorphism in the synaptic input to gonadotropin releasing hormone neurons.

abstract：:The production of hydrogen peroxide (H2O2) as an essential process for iodide organification is a key reaction in TSH-induced thyroid hormone synthesis. Here we characterize the signal transduction pathway involved in TSH-induced H2O2 production in FRTL-5 thyroid cells. At higher than 1 nM TSH, N6-(L-2-phenylisopropyl...

journal_title：Endocrinology

authors： Kimura T,Okajima F,Sho K,Kobayashi I,Kondo Y

更新日期：1995-01-01 00:00:00

abstract：:We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and compared the localization of this 10,000 mol wt CaBP with the localization of the 28,000 mol wt vitamin D-dependent CaBP. Antiserum...

journal_title：Endocrinology

authors： Rhoten WB,Bruns ME,Christakos S

更新日期：1985-08-01 00:00:00

abstract：:Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...

journal_title：Endocrinology

authors： Cho E,Montgomery RB,Mostaghel EA

更新日期：2014-11-01 00:00:00

abstract：:Although the Sertoli cell is a key cell mediating the actions of FSH- and LH-stimulated testosterone (T) in the testis, there is little information to indicate how this cell responds structurally to hormonal insufficiency. The present study used morphometric techniques to study the structural manifestations of the Ser...

journal_title：Endocrinology

authors： Ghosh S,Bartke A,Grasso P,Reichert LE Jr,Russell LD

更新日期：1992-07-01 00:00:00

abstract：:A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities and failed to increase...

journal_title：Endocrinology

authors： List EO,Berryman DE,Basu R,Buchman M,Funk K,Kulkarni P,Duran-Ortiz S,Qian Y,Jensen EA,Young JA,Yildirim G,Yakar S,Kopchick JJ

更新日期：2020-08-01 00:00:00

abstract：:Pulmonary surfactant is a developmentally and hormonally regulated lipoprotein synthesized exclusively in alveolar type II cells. Surfactant protein-A (SP-A) gene transcription in human fetal lung in culture is stimulated by glucocorticoids and cAMP; cAMP also enhances the rate of type II cell differentiation. The CCA...

journal_title：Endocrinology

authors： Breed DR,Margraf LR,Alcorn JL,Mendelson CR

更新日期：1997-12-01 00:00:00

abstract：:Aging of the female reproductive system in rats is marked by discrete stages in the disappearance of regular estrous cyclicity. We determined at which point in the transition to acyclicity changes in the LH pulse generator could be detected by comparing pulsatile LH release in ovariectomized young rats to three groups...

journal_title：Endocrinology

authors： Scarbrough K,Wise PM

更新日期：1990-02-01 00:00:00

abstract：:Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats' obesity, the mechanisms underlying the effects of exercise are unclear. In this study, we determined the effects of running wheel activity on patterns of bod...

journal_title：Endocrinology

authors： Bi S,Scott KA,Hyun J,Ladenheim EE,Moran TH

更新日期：2005-04-01 00:00:00

abstract：:SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in peripheral tissues of diabetic C57BL/KSJ-db/db mice. To clarify the impact of SHIP2 ...

journal_title：Endocrinology

authors： Kagawa S,Soeda Y,Ishihara H,Oya T,Sasahara M,Yaguchi S,Oshita R,Wada T,Tsuneki H,Sasaoka T

更新日期：2008-02-01 00:00:00

abstract：:Postnatal development of the ovine uterus between birth and postnatal day (PND) 56 involves budding differentiation of the endometrial glandular epithelium from the luminal epithelium (LE) followed by extensive coiling and branching morphogenesis of the tubular glands. To determine the short- and long-term effects of ...

journal_title：Endocrinology

authors： Hayashi K,Carpenter KD,Spencer TE

更新日期：2004-07-01 00:00:00

abstract：:The effects of pineal indole compounds on the response of the neonatal rat anterior pituitary gland to LH-releasing hormone (LHRH) were studied in organ culture. After 24 h of culture under control conditions, pituitary glands from 5-day-old female rats were routinely incubated for an additional 24 h with the test com...

journal_title：Endocrinology

authors： Martin JE,Engel JN,Klein DC

更新日期：1977-03-01 00:00:00

abstract：:Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ET(A)R) in murine models of thyroid carcinoma using optical imaging methods. A...

journal_title：Endocrinology

authors： Büther K,Compeer MG,De Mey JG,Schober O,Schäfers M,Bremer C,Riemann B,Höltke C

更新日期：2012-06-01 00:00:00

abstract：:We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...

journal_title：Endocrinology

authors： Globus RK,Patterson-Buckendahl P,Gospodarowicz D

更新日期：1988-07-01 00:00:00

abstract：:We recently reported that bone morphogenetic proteins (BMPs) 2 and 4 can stimulate FSHbeta-subunit (Fshb) transcription alone and in synergy with activins. We further showed that BMP2 signals via the BMP type IA receptor (or activin receptor-like kinase 3) to mediate its effects. However, the intracellular mechanisms ...

journal_title：Endocrinology

authors： Ho CC,Bernard DJ

更新日期：2010-07-01 00:00:00

abstract：:GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs...

journal_title：Endocrinology

authors： Kraicer J,Lussier B,Moor BC,Cowan JS

更新日期：1988-04-01 00:00:00

abstract：:The epidermis has a great potential as a bioreactor to produce proteins with systemic action. However, the consequences of ectopic epidermal protein overexpression need to be carefully addressed to avoid both local and systemic adverse effects. Thus, the long-term effects of leptin on skin physiology have not been stu...

journal_title：Endocrinology

authors： Rico L,Del Rio M,Bravo A,Ramirez A,Jorcano JL,Page MA,Larcher F

更新日期：2005-10-01 00:00:00

abstract：:Media from large vessel endothelial cells (pulmonary artery, aorta) contained intact connective tissue growth factor (CTGF) and a dominant 19-kDa band. N-terminal analysis of the 19-kDa band showed sequence corresponding to CTGF amino acid 181-190, suggesting that the 19-kDa band represented a proteolytic fragment of ...

journal_title：Endocrinology

authors： Boes M,Dake BL,Booth BA,Erondu NE,Oh Y,Hwa V,Rosenfeld R,Bar RS

更新日期：1999-04-01 00:00:00

abstract：:Progesterone, which is normally produced in the endoplasmic reticulum, was found to be rapidly degraded in the cytosolic fraction of the guinea pig adrenal cortex in vitro. Assuming this finding reflects what happens in vivo raises a question as to the source of progesterone for interacting with a nuclear progesterone...

journal_title：Endocrinology

authors： Demura T,Driscoll WJ,Strott CA

更新日期：1990-09-01 00:00:00

abstract：:Thyroid hormone produces a prompt, plasma membrane-mediated increase in several metabolic functions in the rat thymocyte. These effects of thyroid hormone require calcium and are inhibited by the beta-adrenergic antagonist alprenolol. In the present study, the interrelationship between thyroid hormone and adrenergic a...

journal_title：Endocrinology

authors： Segal J

更新日期：1988-05-01 00:00:00

abstract：:Recent evidence indicates that catecholamines may directly alter anterior pituitary function. In the present study, an in vitro perifusion system was used to investigate whether catecholamines affect the gonadotrope. Pituitary tissue from castrated ram lambs was incubated in the presence of epinephrine (EPI), norepine...

journal_title：Endocrinology

authors： Swartz SR,Moberg GP

更新日期：1986-06-01 00:00:00

abstract：:Orexins/hypocretins heavily innervate the posterior division of the paraventricular nucleus of the thalamus (pPVT), which expresses both orexin receptor types. The pPVT is important for adaptations to repeated stress, particularly the ability to facilitate to novel stress after repeated stress exposure. Here, we exami...

journal_title：Endocrinology

authors： Heydendael W,Sharma K,Iyer V,Luz S,Piel D,Beck S,Bhatnagar S

更新日期：2011-12-01 00:00:00

abstract：:We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

journal_title：Endocrinology

authors： Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

更新日期：1993-10-01 00:00:00

abstract：:Fetuin-A is a biomarker reported to be important in many metabolic disorders, including obesity, diabetes, and hepatic steatosis. Although it is well known that fetuin-A is increased in diabetes and nonalcoholic fatty liver disease (NAFLD), the levels of fetuin-A in diabetic patients with NAFLD are unknown. Furthermor...

journal_title：Endocrinology

authors： Ou HY,Wu HT,Hung HC,Yang YC,Wu JS,Chang CJ

更新日期：2012-07-01 00:00:00

abstract：:We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...

journal_title：Endocrinology

authors： Neufeld DS,Platzer M,Davies TF

更新日期：1989-01-01 00:00:00

abstract：:The activity of the Na+/H+ exchanger was studied by measuring the effects of intracellular pH (pHi) and extracellular Na+ [(Na+)o] on pHi recovery and 22Na uptake in rat adipocytes. The resting pHi was acidified from 7.30 +/- 0.02 to 6.99 +/- 0.01 with nigericin in the absence of (Na+)o. pHi recovery induced by 30 mM ...

journal_title：Endocrinology

authors： Arsenis G

更新日期：1995-07-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is controversial whether these agents also act on the pancreatic islet, specifically the α cell, to ...

journal_title：Endocrinology

authors： Dai C,Walker JT,Shostak A,Bouchi Y,Poffenberger G,Hart NJ,Jacobson DA,Calcutt MW,Bottino R,Greiner DL,Shultz LD,McGuinness OP,Dean ED,Powers AC

更新日期：2020-08-01 00:00:00

abstract：:Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at...

journal_title：Endocrinology

authors： Otsuka N,Tong ZB,Vanevski K,Tu W,Cheng MH,Nelson LM

更新日期：2011-06-01 00:00:00

abstract：:Activin A is a gonadal protein originally isolated from follicular fluid and is recognized as a local regulator of granulosa cell differentiation. Whether activin A promotes folliculogenesis, however, still remains unclarified. The present study was designed to elucidate the effect of activin A on follicular growth in...

journal_title：Endocrinology

authors： Yokota H,Yamada K,Liu X,Kobayashi J,Abe Y,Mizunuma H,Ibuki Y

更新日期：1997-11-01 00:00:00

abstract：:We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...

journal_title：Endocrinology

authors： Rabbani SA,Khalili P,Arakelian A,Pizzi H,Chen G,Goltzman D

更新日期：2005-07-01 00:00:00