Abstract：
INTRODUCTION:NF-kB (p50/p65) is a transcription factor involved in TNF-α-induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB (p50 and p65) with serum levels of prostate-specific antigen (PSA), both in normal males and in those with pathologic conditions of the prostate. MATERIALS AND METHODS:this study was carried out in 5 normal, 24 benign prostatic hyperplastic (BPH) and 19 patients with prostate cancer (PC). Immunohistochemical and Western blot analyses were performed on tissue and serum PSA was assayed by PSA DPC Immulite assays (Diagnostics Products Corporation, Los Angeles, CA). RESULTS:in controls, p65 NF-kB was not found and p50 was scantly detected in 60% normal samples in the cytoplasm of epithelial cells. Both p50 and p65 were expressed in 62.5% of the samples with BPH and in 63.2% of those with PC. Both increased its frequency of expression with higher PSA serum levels. CONCLUSIONS:Activation of NF-kB revealed by its nuclear translocation in prostate cancer could be related to cancer progression and elevated seric PSA levels. A better understanding of the biologic mechanism by which circulating PSA levels increase and its relation with NF-kB expression is needed. Possibly, NF-kB blockage could be used as a therapeutic target to counteract proliferation in prostate cancer.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Cansino JR,Vera R,Rodríguez de Bethencourt F,Bouraoui Y,Rodríguez G,Prieto A,de la Peña J,Paniagua R,Royuela Mdoi
10.1016/j.acuro.2010.08.002subject
Has Abstractpub_date
2011-01-01 00:00:00pages
16-21issue
1eissn
0210-4806issn
1699-7980pii
S0210-4806(10)00438-9journal_volume
35pub_type
杂志文章abstract：CONTEXT:High-dose rate brachytherapy (HDR-BT) is an increasingly popular treatment for patients with localised prostate cancer (PC). OBJECTIVE:To assess the safety and efficacy of HDR-BT as monotherapy in PC. ACQUISITION OF EVIDENCE:A systematic literature review was conducted through searches on MEDLINE (PubMed), Co...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/j.acuro.2016.06.001
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:Overactive bladder (OB) is one of the no-neurogenic voiding dysfunctions whose prevalence has been precisely defined among the general population but not so among the paediatric population. Its clinical manifestations are various, and its association with other pathologies like enuresis, vesico-ureteral re...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(04)73050-8
更新日期：2004-02-01 00:00:00
abstract：:Presentation of 11 cases of retroperitoneal sarcoma. Mean time from the beginning of symptoms to diagnosis is 6 months. The primary complementary study is CT. Surgery was performed in all cases, using complete resection in 6 cases, and partial resection in 5. Ten patients relapsed. 9 of which were treated with surgica...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To determine the current state of vesicouterine fistulae in our hospital, the factors associated with their development and the findings obtained from the treatments used. MATERIAL AND METHODS:We carry out a retrospective study on a group of patients suffering from vesicouterine fistulae who were treated in ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(03)73000-9
更新日期：2003-10-01 00:00:00
abstract：:The epidermic growth factor (EGF) is a polypeptide which stimulates tissue proliferation. The mechanism of action takes place through an specific membrane receptor, known as the EGFR. Recent scientific contributions have allowed to know its implication in various tumoral processes (breast, ovary, bladder, etc), so tha...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Description of 17 cases of columns of Bertin's hypertrophy found by chance while performing 587 urological ecographies carried out while following other urogenital diagnostic approaches. The present report is prompted by the entity's features and the differential diagnosis forced by the "renal mass effects". A series ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Treatment of infiltrant vesical cancer has traditionally been the grounds for intense controversy. Transurethral resection (TUR) followed by high voltage radiotherapy (RT) in selected cases of locally advanced vesical urothelial tumours can be a valid alternative for the treatment of this condition. This paper disclos...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Urinary tract complications continue to be a major cause of morbidity in renal transplant patients. This paper is a review of the urological complications developed in in 200 renal transplants performed in our service over a 10-year period, from January 1980 to December 1989, with a follow-up of at least 1 year. We in...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：UNLABELLED:Orthotopic renal transplant (ORT) is useful in cases of severe atherosclerosis, heterotopic bilateral transplant, unsuitable pelvic vessels and in aortic thrombosis, but it is not available in all the institutions and it is only realized of exceptional form. AIM:To review the indication, surgical technique ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(07)73774-9
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Nephroureterectomy is one of the procedures for which a laparoscopic approach is more clearly indicated. However, despite the long experience available, management of the distal ureter is still difficult. MATERIALS AND METHODS:Thirty-two laparoscopic nephroureterectomies were performed from November 2004 ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:Benign prostatic hypertrophy (BPH) is a common urological disease with a standard surgical approach, transurethral resection (TUR) or open adenectomy (OA), but the flowmetric clinical results are controversial. Fifty-five patients were evaluated; in 23 of them TUR was performed and 32 underwent OA. The Boyarsky clinic...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:Prostate cancer (PCa) is the second leading cause of cancer-related mortality and the most frequently diagnosed male malignant disease among men. The manifestation of PCa ranges from indolent to highly aggressive disease and due to this high variation in PCa progression, the diagnosis and subsequent treatment planning...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/j.acuro.2019.08.003
更新日期：2020-04-01 00:00:00
abstract：:The brucellosis is an unusual entity whose incidence has diminished due to the improvement in preventive measures. We have carried out a retrospective study of all the patients admitted in our service between 1996 and 1998, with diagnosis of orchitis. Two of the 31 patients admitted for this reason presented a final d...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(01)72589-2
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVE:To analyse the value of a second transurethral resection, repeated within 3 to 6 weeks after the initial resection, in the treatment and the classification of patients with bladder tumour. MATERIAL AND METHODS:We analyse the results of 72 repeated transurethral resection in 23 (32%) patients with T1 G1-2 bla...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(01)72596-x
更新日期：2001-03-01 00:00:00
abstract：:Fifty-one patients with non-seminoma testicular cancer who underwent retroperitoneal ganglion dissection and 3 support cycles of chemotherapy with Cys-Platin, Vinblastine and Bleomycin. Four patients presented relapses (7.8%). Actuarial survival by 8 years was 87%, with a median of 38 months. The median survival was 4...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:We present our 20 years experience treating patients with vena cava extension in whom an extracorporeal circulation, hypothermia, cardio circulatory arrest (ECC-H-CCA) in order to perform, together with a tumoral resection, a thrombus resection. MATERIAL AND METHODS:From 1985 to 2005 a total of 28 retroperit...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.4321/s0210-48062008000400003
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To comment on the most relevant aspects and to review the literature on this unusual pathology. MATERIAL AND METHODS:We present two cases of cystic lymphangioma, their clinical, diagnosis, therapy and development, and we review the actual literature. The first case is a young man with the diagnosis of cystic...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(06)73525-2
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:The increasing number of ultrasonographically detected asymptomatic, renal dilations have caused a lot of explorations to be performed in these patients. The Society of Fetal Urology proposed a four grades classification of echographic renal dilations and renographic studies are recommended in grades II to IV. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(01)72568-5
更新日期：2001-01-01 00:00:00
abstract：:As a novel item we present a case of the reconversion of a Bricker-Wallace type external urinary bypass into vesical replacement according to Camey technique type II. 5 years after radical cystectomy and external urinary bypassing due to a malignant infiltrating vesical carcinoma and considering the patient's malignan...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：INTRODUCTION:Plaque and bovine pericardium graft surgery is a useful tool for treating Peyronie's disease. OBJECTIVE:To determine patient satisfaction following this operation. MATERIALS AND METHODS:This was a retrospective, observational and descriptive study. We collected data from the medical records of patients w...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2016.05.006
更新日期：2017-03-01 00:00:00
abstract：:Patient treated by dialysis for end-stage renal disease are at increased risk of many cancers, especially those of kidney and urinary tract. A 56 years old man who undergoing chronic dialysis, presented in ultrasonography a 2 cm complex cystic mass in the left kidney what was confirmed by computed tomography and magne...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73884-1
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Analyze technical details and results of laparoscopic treatment of ureterolithiasis. MATERIALS AND METHODS:Between January 2005 and August 2008 it was performed laparoscopic ureterolithotomy in 22 patients in our service. Two (9%) by retroperitoneal access and 20 (91%) by transperitoneal access. Mean size of...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(09)74205-6
更新日期：2009-06-01 00:00:00
abstract：RATIONALE:To investigate whether, in the same way incidence is affected, biological aggressiveness of bladder cancer at diagnosis is greater in men than in women. METHOD:Using data from a retrospective study on urothelial cancer of the bladder between 1975 and 1991 in La Rioja (Spain), an estimate was made of total Re...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:Nosocomial infection rates constitute an indicator of welfare quality, permitting to adopt measures of prevention and control. It has been developed a surveillance plan of the nosocomial infection in hospitals, showing to be an efficient method to diminish its incident. OBJECTIVE:To know the indicators an...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：OBJETIVES:Radical cystectomy is the standard treatment for localised muscle invasive bladder cancer (MIBC). We offer a bladder-sparing treatment with TURB +/- Chemotherapy+Radiotherapy to selected patients as an alternative. MATERIAL AND METHODS:We analyze, retrospectively, 30 patients diagnosed with MIBC from March 1...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2013.03.004
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To study the influence, in terms of prognosis, of the finding of seminal vesicle involvement in patients with prostate adenocarcinoma treated with radical prostatectomy. MATERIAL AND METHOD:We reviewed a series of patients with seminal vesicle involvement with clinically localized prostate adenocarcinoma who...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2014.05.009
更新日期：2015-04-01 00:00:00
abstract：:We report a strange case of a bladder whose first metastasic manifestation, after two years of the diagnosis, was a peripheric polyneuropathia. This patient was treated with immunotherapy with BCG for superficial carcinoma of the bladder during one year. Gradually central neurological symptoms appeared and the patient...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(99)72387-9
更新日期：1999-11-01 00:00:00
abstract：INTRODUCTION:Absolute priority in an LDKT programme are donnor safety and kidney optimal anatomical and functional preservation. Reduced donnor morbidities, both at short and long term, are important objectives. Excellent technical grafting is a must as are the strategies employed for facilitatig it. We revised the inc...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73977-9
更新日期：2008-11-01 00:00:00
abstract：:Localized amyloidosis of the urethra is a rare pathological entity. Biopsy is required to make the appropriate diagnosis. Although localized therapy is available for obstructing, symptomatic lesions, asymptomatic lesions may be followed with conservative management and spontaneous regression has been reported. An appr...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(02)72728-9
更新日期：2002-01-01 00:00:00
abstract：:We presented a case of inferior vena cava on the left side diagnosed by abdominal CT scan during the study of a renal cell carcinoma in the right side. This anomaly is very rare but it may suppose a more difficult approach to the nephrectomy. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(05)73320-9
更新日期：2005-07-01 00:00:00
