[Monitoring activities and improvement in the use of antibiotics in Spanish hospitals: results of a national survey].

Abstract:

OBJECTIVES:To describe: 1) the main features of antimicrobial stewardship activities (ASA) in Spanish hospitals and 2) the perceptions of the Spanish Infectious Diseases (ID) community on ASA. METHODS:An online survey was designed and distributed through the e-mailing lists of several working groups of the Spanish Clinical Microbiology and Infectious Diseases Society. RESULTS:Between September 15 and November 23, 2009, surveys representing 78 hospitals were received. Most of the respondents were either ID physicians (30%) or microbiologists (29%), and 31/78 hospitals (40%) had ongoing ASA. These hospitals were concentrated in 4 of the 17 regions, particularly in Catalonia. Professionals belonging to 26/31 centres with ASA completed the survey. The most frequent principles of antibiotic (ABX) stewardship implemented in these programs were: 1) ABX streamlining (22/26) and 2) intravenous to oral switch (22/26) followed by 3) strategic monitoring of ABX (21/26). In 22/26 (86%) of the centres with ASA any physician could initially prescribe any of the antimicrobials included in the formulary. The most frequent activity carried out was ABX restriction, 69% (18/26) followed by conferences 61% (16/26) and therapeutic audit and feed-back 54% (14/26). When asked which antimicrobials that should be closely monitored, carbapenems were considered by all respondents in centres with ongoing ASA. CONCLUSIONS:1) A minority (40%) of the surveyed hospitals in Spain has an ongoing ASA and large geographical variations were observed. 2) ASA were most commonly structured in the form of an integrated part-time multidisciplinary team of ID physicians and Pharmacists, and 3) Carbapenems were considered the ABX most required to be monitored.

authors

Paño-Pardo JR,Padilla B,Romero-Gómez MP,Moreno-Ramos F,Rico-Nieto A,Mora-Rillo M,Horcajada JP,Ramón Arribas J,Rodríguez-Baño J

doi

10.1016/j.eimc.2010.05.005

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

19-25

issue

1

eissn

0213-005X

issn

1578-1852

pii

S0213-005X(10)00397-6

journal_volume

29

pub_type

杂志文章,多中心研究
  • [Characterisation of a CTX-M-15-producing Shigella sonnei in a Spanish patient who had not travelled abroad].

    abstract::One hundred and seven Shigella spp. strains were isolated in our laboratory during the years 2000 to 2010. One Shigella sonnei harboured the genes that coded the β-lactamases TEM-1 and CTX-M-15, identifying the structure, ISEcp1+bla(CTX-M-15)+orf477, in their genetic environment. The strain also carried a class 2 inte...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2011.11.015

    authors: Seral C,Rojo-Bezares B,Garrido A,Gude MJ,Sáenz Y,Castillo FJ

    更新日期:2012-10-01 00:00:00

  • [Dental implant-related infections].

    abstract::Dental implant-associated infections are expected to be increasingly more common as the number of patients with implants for more than 10 years rises. There are 2 stages of peri-implant infection: early mucositis, consisting of inflammation of the peri-implant soft tissues without loss of supporting bone, and a more a...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13128277

    authors: López-Cerero L

    更新日期:2008-11-01 00:00:00

  • Vancomycin-resistant enterococci among haemodialysis patients in Portugal: prevalence and molecular characterization of resistance, virulence and clonality.

    abstract:INTRODUCTION:Vancomycin-resistant enterococci (VRE) among haemodialysis patients has increased rapidly and, to date, there is no report of this incidence in Portugal. METHODS:A total of 121 faecal samples were collected from haemodialysis patients, and then tested for VRE. Antimicrobial resistance, virulence and multi...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2013.09.001

    authors: Correia S,Ponce P,Jones-Dias D,Caniça M,Igrejas G,Poeta P

    更新日期:2014-03-01 00:00:00

  • Persistence of a ST6 clone of Enterococcus faecalis genotype vanB2 in two Hospitals in Aragon (Spain).

    abstract:INTRODUCTION:In order to study the evolution of the outbreak that occurred between 2009 and 2010 in 3 hospitals in Zaragoza, all vancomycin-resistant clinical Enterococcus faecalis isolates identified between 2011 and 2013 at these hospitals were characterised. METHODS:Molecular characterisation of the isolates and an...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eimc.2016.02.020

    authors: Alonso CA,Rezusta A,Seral C,Ferrer I,Castillo FJ,Torres C

    更新日期:2017-11-01 00:00:00

  • Strategies for the cure of HIV infection.

    abstract::The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of H...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2018.01.007

    authors: Rodríguez-Muñoz J,Moreno S

    更新日期:2019-04-01 00:00:00

  • [Candida: epidemiology and risk factors for non-albicans species].

    abstract:INTRODUCTION:Nosocomial fungal infections have increased significantly in the last decade. Candida detection in clinical specimens can mean either colonization or an infection which can be local (muguet) or invasive. Knowledge of the species helps in choosing the best treatment. The aims of this study were to determine...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2012.09.011

    authors: Cornistein W,Mora A,Orellana N,Capparelli FJ,del Castillo M

    更新日期:2013-06-01 00:00:00

  • [Study of the viral etiology of lower respiratory tract infections in a neonatal unit].

    abstract:OBJECTIVE:To study the possible viral etiology in 139 infants with lower respiratory tract infection who required hospitalization in the Infant Unit of our hospital, from October 1994 to June 1995. PATIENTS AND METHODS:139 patients were admitted, aged from 13 days to 14 months, during this period. The etiological agen...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Fortea J,González-Cuevas A,Juncosa T,García-Fructuoso MT,Martínez F,Muñoz C,Gené A,Latorre C

    更新日期:1998-12-01 00:00:00

  • [Fever of intermediate duration].

    abstract::Fever of intermediate duration (FID) is defined as non-localized fever occurring in the community, lasting from one to four weeks, and having no diagnostic orientation after basic clinical, analytical and radiological evaluations are completed. These may include careful recording of clinical history, physical examinat...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0213-005x(03)72904-8

    authors: Rivero A,Zambrana JL,Pachón J

    更新日期:2003-03-01 00:00:00

  • Symtuza® in clinical practice.

    abstract::Because lifelong therapy is needed in HIV infection, high long-term adherence is necessary. Darunavir/co-bicistat/emtricitabina/tenofovir alafenamide (Symtuza®) is the first triple therapy combining a protease inhibitor (PI) in a single tablet regimen. This drug combines the potency and high genetic barrier of the mos...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/S0213-005X(18)30395-1

    authors: Luis Casado J,Fontecha M,Monsalvo M,Vizcarra P

    更新日期:2018-12-01 00:00:00

  • [Guidelines for the treatment of invasive fungal disease by Aspergillus spp. and other fungi issued by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). 2011 Update].

    abstract::The guidelines on the treatment of invasive fungal disease by Aspergillus spp. and other fungi issued by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) are presented. These recommendations are focused on four clinical categories: oncology-haematology patients, solid organ transplant recip...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.eimc.2011.01.010

    authors: Fortún J,Carratalá J,Gavaldá J,Lizasoain M,Salavert M,de la Cámara R,Borges M,Cervera C,Garnacho J,Lassaleta Á,Lumbreras C,Sanz MÁ,Ramos JT,Torre-Cisneros J,Aguado JM,Cuenca-Estrella M,Grupo de Estudio de Micología Médica

    更新日期:2011-06-01 00:00:00

  • [Bacteremia and recurrent arthritis caused by Streptococcus pyogenes in a heroin addict with AIDS].

    abstract:BACKGROUND:Streptococcus pyogenes is a bacteria which, at present, is seldom isolated in blood and articular fluid. An intravenous drug addict with human immunodeficiency virus infection, with bacteremia and arthritis by S. pyogenes, associated with tuberculosis is presented. METHODS:Blood and articular fluid cultures...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Santos J,Fernández A,Arana C,Falces A,Márquez M,Rivero A

    更新日期:1994-10-01 00:00:00

  • Streptococcus suis spondylodiscitis: 2 new cases and a literature review.

    abstract:INTRODUCTION:Streptococcus suis (S. suis) infection is poorly described zoonosis in our country, which is related with exposure to pigs or their meat. The most common clinical presentation is meningitis, while spinés involvement is rare. METHODS:We report 2 cases of S. suis infection and perform a systematic review of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2020.08.005

    authors: Romay-Lema EM,Ventura-Valcárcel P,Iñiguez-Vázquez I,García-Pais MJ,García-Garrote F,Rabuñal-Rey R,Alonso MP,Corredoira-Sánchez J

    更新日期:2020-10-14 00:00:00

  • Antibacterial activity of Citrus hystrix toward Salmonella spp. infection.

    abstract:INTRODUCTION:Citrus hystrix is widely used by Indonesians as a traditional medicine for gastrointestinal diseases, including Salmonella spp. infection. We investigated the antibacterial activity of the ethanolic peel extract of C. hystrix against Salmonella typhimurium. METHODS:The antibacterial activity was evaluated...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2020.05.016

    authors: Ulhaq ZS,Hendyatama TH,Hameed F,Santosaningsih D

    更新日期:2020-07-04 00:00:00

  • [Interpretive reading of enterobacteria antibiograms].

    abstract::The resistance pattern observed in the antibiogram of an isolate should be the sum of its natural resistance pattern, characteristic of the species, plus the acquired resistances. In Enterobacteriaceae, the production of inactivating enzymes is the main mechanism of resistance to beta-lactams and aminoglycosides. Each...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2010.05.002

    authors: Navarro F,Miró E,Mirelis B

    更新日期:2010-11-01 00:00:00

  • Fosamprenavir (GW433908)/ritonavir in HIV-infected patients: efficacy and safety results from the Spanish Expanded Access Program.

    abstract:INTRODUCTION:The use of protease inhibitors (PI) has led to a decrease in HIV-1-related mortality and morbidity. The objective of this study was to collect safety data on treatment with fosamprenavir/ritonavir (FPV/r) 700/100mg BID in HIV-infected patients through an expanded access program. PATIENTS AND METHODS:Prosp...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.eimc.2008.05.002

    authors: Pérez-Elias MJ,Sánchez-Conde M,Soriano V,Mallolas J,Luque I,Rodríguez-Alcántara F,Fosamprenavir Expanded Access Program Group.

    更新日期:2009-01-01 00:00:00

  • [Hospital personnel who are nasal carriers of methicillin-resistant Staphylococcus aureus. Usefulness of treatment with mupirocin].

    abstract:BACKGROUND:The evaluation of health care workers role in methicillin-resistant Staphylococcus aureus outbreaks and the efficacy of mupirocin as a topical agent for nasal carriers. METHOD:Microbiologic study of nasal microflora of 1547 health care workers from the San Carlos University Hospital and 108 health care work...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Gaspar MC,Uribe P,Sánchez P,Coello R,Cruzet F

    更新日期:1992-02-01 00:00:00

  • [Longitudinal study on adherence, treatment satisfaction, and effectiveness of once-daily versus twice-daily antiretroviral therapy in a Spanish cohort of HIV-infected patients (CUVA study)].

    abstract:INTRODUCTION:Adherence is essential for successful antiretroviral therapy (ART), but complex dosing schedules compromise the adherence to and efficacy of this treatment. Once-daily (QD) ART simplifies treatment by lowering the dosing frequency and pill burden. The aim of this study, performed when QD regimens were stil...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1157/13116748

    authors: Viciana P,Rubio R,Ribera E,Knobel H,Iribarren JA,Arribas JR,Pérez-Molina JA,Investigadores del Estudio CUVA.

    更新日期:2008-03-01 00:00:00

  • [Epidemiologic and therapeutic aspects of bacteremic infections of the urinary tract].

    abstract::A survey was carried out of all urinary tract infections which developed bacteremia during an 18 month period. The number of episodes of bacteremia of urinary origin (BUO) detected in our institution during that period was 108. The urinary tract was the most common origin of the cases of community acquired (CA) bacter...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Tomás S,Torné J,Soriano JC,García-Flores A,Garcés JM,Drobnic L,Morta M,Torres JM

    更新日期:1989-02-01 00:00:00

  • Pregnancy, obesity and other risk factors for complications in influenza A(H1N1) pdm09 infection.

    abstract::Although influenza is usually a self-limited disease, patients who develop complications are at increased risk of hospitalization, intensive care unit admission and death. Since preventive and early therapeutic measures should be prioritized in higher risk patients, identification of the risk factors for severe infect...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/S0213-005X(12)70102-7

    authors: Rodríguez-Baño J,Paño-Pardo JR,Múñez Rubio E,Segura Porta F

    更新日期:2012-10-01 00:00:00

  • [New anaerobic bacterial species in human infections].

    abstract::This review offers succinct, precise, and complete information based on the available data concerning new anaerobic bacterial species involved in infectious diseases in humans. All hitherto undescribed species, those not previously implicated in clinical conditions, those with confirmed implication in human disease th...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2008.09.015

    authors: García-Sánchez JE,José Fresnadillo M,García-Sánchez E

    更新日期:2010-03-01 00:00:00

  • Surveillance of surgical site infections in elective colorectal surgery. Results of the VINCat Program (2007-2010).

    abstract::The VINCat Program is a standardized surveillance program of healthcare infections in Catalonia, Spain. This program includes monitoring of surgical site infections (SSI) of elective colorectal surgery. The aim of this study was to define SSI rates in colorectal surgery among VINCat hospitals over a period of 4 years....

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/S0213-005X(12)70092-7

    authors: Pujol M,Limón E,López-Contreras J,Sallés M,Bella F,Gudiol F,VINCat Program.

    更新日期:2012-06-01 00:00:00

  • [Otomycosis: presentation of 15 cases].

    abstract::Fifteen cases of otomycosis in 11 women and 4 men attending the Clinic Hospital in Salamanca during the period from 1984 to 1988 are discussed. A. niger was the species isolated on the majority of occasions (73.3%). The commonest form of presentation of otomycosis was simple chronic (73.3%). The clinical pictures was ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Martín AM,Canut A,Muñoz S,Pescador C,Gómez JL

    更新日期:1989-05-01 00:00:00

  • [Bronchiolitis caused by influenza type A virus. An emerging infectious disease].

    abstract:OBJECTIVES:To prospectively study the emergence and diagnostic problems of bronchiolitis caused by influenza A virus among children durign the 1999-2000 influenza epidemic. MATERIALS AND METHODS:Negative respiratory syncitial virus (RSV) specimens (ELISA dot-blot) were seeded in the MDCK cell line for the isolation of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/s0213-005x(01)72703-6

    authors: Reina J,Ballesteros F,Mesquida X,Galmes M,Ferres F,Ruiz De Gopegui E

    更新日期:2001-12-01 00:00:00

  • [Viral infections associated with intestinal invagination].

    abstract::Intestinal invagination is rather frequently associated with local tumors, adenovirus infections, and occasionally with Yersinia enterocolitica. However, in many cases the etiology is not known. We have studied 88 children with intestinal invagination in whom cellular cultures of Hep 2 and pulmonary fibroblasts of hum...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:

    authors: Calicó I,Bertrán Sangués JM,Elcuaz Romano RI,Casal J,Suñé Gracia MJ

    更新日期:1990-08-01 00:00:00

  • [Entecavir].

    abstract::Chronic hepatitis B continues to be a serious problem worldwide. Because a high viral load is associated with greater progression to cirrhosis and hepatocarcinoma in these patients, new drugs that achieve rapid, potent and lasting suppression of viral replication must be sought. Entecavir is a new, highly potent antiv...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0213-005x(08)76518-2

    authors: Calleja JL,Peñas B

    更新日期:2008-05-01 00:00:00

  • Peripheral facial palsy after varicella. Report of two cases and review of the literature.

    abstract:BACKGROUND:There is little information regarding peripheral facial palsy (PFP) as a complication of varicella. We describe 2 adults who developed varicella-related PFP, in 1 case as a part of Guillain-Barré syndrome (GBS), and review all reported cases of this condition. METHODS:MEDLINE search. RESULTS:A total of 10 ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2009.09.009

    authors: Muñoz-Sellart M,García-Vidal C,Martínez-Yelamos S,Niubó J,Fernández-Viladrich P

    更新日期:2010-10-01 00:00:00

  • [Q fever in Gran Canaria: 40 new cases].

    abstract:INTRODUCTION:The aim of this study was to describe the clinical and epidemiologic features of Q fever in the southern area of the island of Gran Canaria (Spain). METHODS:We conducted a retrospective analysis of the clinical and epidemiological data of the cases of Q fever diagnosed by the Microbiology Laboratory of th...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/s0213-005x(03)72869-9

    authors: Bolaños M,Santana OE,Pérez-Arellano JL,Angel-Moreno A,Moreno G,Burgazzoli JL,Martín-Sánchez AM

    更新日期:2003-01-01 00:00:00

  • Persistence of Zika virus in semen 93 days after the onset of symptoms.

    abstract:INTRODUCTION:Zika virus is mainly transmitted through the bites of infected Aedes mosquitoes, although mother-to-child and sexual transmission have also been described. The presence of Zika virus in semen after infection seems to be not uncommon, but the duration of viral persistence has not been well-determined. METH...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2016.10.009

    authors: Oliveira Souto I,Alejo-Cancho I,Gascón Brustenga J,Peiró Mestres A,Muñoz Gutiérrez J,Martínez Yoldi MJ

    更新日期:2018-01-01 00:00:00

  • [Infection by Mucorales fungi].

    abstract::Mucormycosis is a rare opportunistic fungal infection of immunosuppressed patients. We describe here 5 cases of mucormycosis: three with facial and eye involvement, one with lung involvement and one affecting skin and joints. All five patients had underlying diseases: diabetes, leukemia, lymphoma, neoplasia and AIDS. ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Pintado V,Valencia E,López-Dupla JM,Lavilla P,González A,Gil A

    更新日期:1991-10-01 00:00:00

  • [Hepatitis B at an open institution for the mentally retarded. Immunogenic effect of a recombinant anti-hepatitis-B vaccine].

    abstract::The diffusion of hepatitis B virus was investigated in an open institution for mentally retarded patients, where 24 patients with Down's syndrome (DS) and 94 with other types of mental retardation (OMR) were being cared for. The immunogenic response to a recombinant vaccine intramuscularly injected to the deltoid musc...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:

    authors: García O,Bruguera M,Mayor A,Sánchez-Tapias JM,Vall O,Rodés J

    更新日期:1990-03-01 00:00:00