Abstract：
STUDY DESIGN:The study was designed as a single-arm clinical trial. OBJECTIVES:To investigate the therapeutic effects of detrusor botulinum toxin A (BoNT-A) treatment in patients with different levels of spinal cord injury (SCI) and types of detrusor sphincter dyssynergia (DSD). SETTING:Patients with chronic suprasacral SCI and neurogenic detrusor overactivity (NDO) were treated with 200-U BoNT-A detrusor injection in a tertiary university hospital in Taiwan. METHODS:Outcome assessment of urodynamic parameters and therapeutic satisfaction were performed at 3 and 6 months among patients with different demographics, SCI levels and types of DSD. The treatment outcomes were assessed by changes in Urogenital Distress Inventory 6-item short form (UDI-6), quality of life (QoL) index and detrusor pressure at maximum flow rate (Pdet.Qmax). RESULTS:A total of 38 patients with a mean age of 40.1±12.4 years and median duration of SCI of 10.3 years were enrolled. Satisfactory response was reported in 23 (60%) patients. Significant improvements in the UDI-6 and QoL were reported and significant increases of cystometric bladder capacity and post-void residual were noted in overall patients after treatment. Patients with different clinical demographics and urodynamic parameters had similar treatment outcomes and UDI-6 scores. In 11 patients receiving repeat injections of 300 U of BoNT-A after failure of a previous 200 U injection, the treatment outcomes were not significantly different, except that the PdetQmax at 6 months were higher in the group that received 200 U of BoNT-A. CONCLUSION:Patients with different SCI levels or DSD types had similar treatment outcomes after detrusor 200 U BoNT-A injections for NDO.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Chen CY,Liao CH,Kuo HCdoi
10.1038/sc.2010.179subject
Has Abstractpub_date
2011-05-01 00:00:00pages
659-64issue
5eissn
1362-4393issn
1476-5624pii
sc2010179journal_volume
49pub_type
临床试验,杂志文章相关文献
SPINAL CORD文献大全abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Spinal cord
pub_type： 已发布勘误
doi：10.1038/s41393-020-00534-z
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:To validate the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) in paediatric spinal cord injuries (SCIs) patients admitted to the tertiary SCI centre. METHODS:children's baseline clinical data, anthropometric measurements and STAMP score were assessed on admission. The validity of ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.166
更新日期：2013-05-01 00:00:00
abstract：STUDY DESIGN:Prospective cohort study. OBJECTIVES:To evaluate the relationship between quality of life (QOL) after a traumatic spinal cord injury (TSCI) and acute predictors, with a particular emphasis on the initial severity of the neurological injury. Secondarily, to compare the QOL after a TSCI with the general pop...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0178-8
更新日期：2018-11-01 00:00:00
abstract：STUDY DESIGN:Prospective. OBJECTIVES:To test whether provocative stimulation of the testes identifies men with chronic spinal cord injury (SCI), a population in which serum testosterone concentrations are often depressed, possibly due to gonadal dysfunction. To accomplish this objective, conventional and lower than th...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.8
更新日期：2017-07-01 00:00:00
abstract：STUDY DESIGN:Review. OBJECTIVES:This review article investigated the objective evidence of benefits derived from functional electrical stimulation (FES)-assisted gait for people with spinal cord injury (SCI). Both FES and gait have been proposed to promote not only augmented health and fitness, but specific ambulatory...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3102101
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND CONTEXT:Spondyloarthropathy has been described radiographically in patients following paralysis from spinal cord trauma. Onset of these findings after cauda equina syndrome have not been reported previously. Furthermore, the magnetic resonance documentation of its early evolution has not been recorded. PURP...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.190
更新日期：2015-03-01 00:00:00
abstract：STUDY DESIGN:Self-reported survey. OBJECTIVE:Our purpose was to identify the predictors of pain medication misuse (PMM) among participants with spinal cord injury (SCI). SETTING:A medical university in the southeastern United States. METHODS:A total of 919 adults with impairment from traumatic SCI of at least 1-year...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.42
更新日期：2015-08-01 00:00:00
abstract：STUDY DESIGN:Randomized, assessor-blinded trial. OBJECTIVES:To evaluate the effectiveness of a 6-week task-specific training programme on the abilities of people with chronic spinal cord injuries to sit unsupported. SETTING:NSW, Australia. METHODS:Thirty adults with spinal cord injuries of at least 1-year duration w...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sc.2009.88
更新日期：2010-02-01 00:00:00
abstract：STUDY DESIGN:A prospective cohort with acute tetraplegia. OBJECTIVES:Obstructive sleep apnoea (OSA) is common within weeks of tetraplegia. This study aimed at determining the feasibility of auto-titrating continuous positive airway pressure (CPAP) to treat OSA after acute tetraplegia. SETTING:The Victorian Spinal Cor...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2009.56
更新日期：2009-12-01 00:00:00
abstract：STUDY DESIGN:A case report of Neisseria sicca/subflava discitis in a healthy elderly female. OBJECTIVE:To report a rare case, which is usually seen exclusively in children. SETTING:Stoke on Trent, England. METHOD:Case report, a 65-year-old female with a 6 month history of back and bilateral leg pain. X-rays showed c...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101497
更新日期：2003-10-01 00:00:00
abstract：:Spinal cord-injured (SCI) patients often suffer from symptomatic polymicrobial urinary tract infection (UTI). The objective of this study was to evaluate the clinical outcome and cost-savings associated with antibiotic therapy based on limited vs full microbiological investigation of urine cultures in adult SCI patien...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.sc.3100429
更新日期：1997-08-01 00:00:00
abstract：STUDY DESIGN:This cross-sectional chart review study included 100 US Veterans with spinal cord injuries/disorders (SCI/D) who received care at a Veterans Affairs (VA) SCI facility during a 12-month period. Progress notes were examined to extract need for weight management (WM), patient-provider discussions about risk d...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.59
更新日期：2016-12-01 00:00:00
abstract：STUDY DESIGN:Psychometric study based on retrospectively collected data. OBJECTIVE:Development of a pressure injury (PI) risk screening instrument for use during spinal cord injury (SCI) rehabilitation. SETTING:Tertiary rehabilitation center. METHODS:Medical charts of 807 inpatients participating in SCI rehabilitati...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-0510-y
更新日期：2020-07-21 00:00:00
abstract：STUDY DESIGN:A randomized, blinded, crossover clinical trial comparing sildenafil versus tadalafil for erectile dysfunction (ED) in male spinal cord-injured (SCI) patients. OBJECTIVES:To compare the safety, time/duration effectiveness, and the impact on the quality of life (QoL) of tadalafil 10 mg versus sildenafil 50...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.sc.3101617
更新日期：2004-11-01 00:00:00
abstract：STUDY DESIGN:Cohort cross-sectional study. OBJECTIVE:To investigate the relationship between cardiac vagal activity and left ventricular filling at rest and during vagal stimulation, via the cold face test (CFT), in individuals with spinal cord injury (SCI). SETTING:University-based laboratory at Brock University, St...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0224-6
更新日期：2019-05-01 00:00:00
abstract：STUDY DESIGN:Intra-rater reliability study, cross-sectional design. OBJECTIVES:To determine reliability of the International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI) motor and sensory exam in children. SETTING:Nonprofit pediatric hospital. METHODS:In all, 74 subjects had two trials of...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101987
更新日期：2007-06-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional comparison, control group. OBJECTIVES:To investigate the relationship between carotid arterial stiffness and circulating markers for cardiovascular disease (CVD) in spinal cord-injured (SCI) subjects compared with able-bodied (AB) individuals. SETTING:University Research Laboratory, Unive...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.56
更新日期：2011-09-01 00:00:00
abstract：STUDY DESIGN:A pilot study measuring the levels of serum-soluble CD95 ligand (CD95L) in eight spinal cord-injured patients. OBJECTIVES:To determine the soluble concentration of CD95L in spinal cord injury (SCI) patients after trauma. METHODS:We collected blood samples from eight patients with acute traumatic SCI. Sol...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.139
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To compare the data obtained through video urodynamics (VUD) with those obtained through one voiding cycle ambulatory urodynamics monitoring (AUM) in patients with spinal cord injury (SCI). METHODS:A comparative study was conducted in 69 patients with SCI (mean age±s.d. 44±16.9 years), 51 men and 18 women, w...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.9
更新日期：2014-07-01 00:00:00
abstract：STUDY DESIGN:Intra- and inter-rater reliability study. OBJECTIVES:To assess intra- and inter-rater reliability of the Modified Ashworth Scale (MAS) and Spasm Frequency Score (SFS) in lower extremities in a population of spinal cord-injured persons, as well as correlations between the two scales. SETTING:Clinic for Sp...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.230
更新日期：2016-09-01 00:00:00
abstract：STUDY DESIGN:Multicenter prospective cohort. OBJECTIVE:To discern neurological- and functional recovery in patients with a traumatic thoracic spinal cord injury (TSCI), conus medullaris syndrome (CMS), and cauda equina syndrome (CES). SETTING:Specialized spinal cord injury centers in Europe. METHOD:Lower extremity m...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-0463-1
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and safety over a 10-year period of any urological operations required by female patients with spinal cord lesions (SCLs). METHODS:Retrospective study of urological surgeries from our database performed on females with SCLs from 2001 to 2002. Surgery efficacy for neurogenic lower ur...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.64
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To provide an overview of our current understanding of the problem of neuropathic pain following spinal cord injury (SCI) and to suggest possible therapeutic options in the near future. METHODS:Original research articles, reviews and book chapters on the subject of pain and SCI. RESULTS:Neuropathic pain fol...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2008.136
更新日期：2009-05-01 00:00:00
abstract：STUDY DESIGN:Retrospective study of mobility of the spine. OBJECTIVES:To study the relation between mobility of the spine, operation and length of surgical stabilisation. SETTING:The National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK. METHOD:Questionnaires were sent to 99 consecutive acute tra...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101528
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Bone mineral density (BMD) of the lumbar spine (L-spine) has been reported to be normal or increased in persons with chronic spinal cord injury (SCI). OBJECTIVE:To determine BMD of the L-spine by dual-energy X-ray absorptiometry (DXA) and quantitative computerized tomography (qCT) in men with chronic SCI co...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2008.169
更新日期：2009-08-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional, questionnaire-based study. OBJECTIVES:To test the hypothesis that self-perceived functional impairment and religiosity/spirituality (S/R) predict depression among traumatic spinal cord injury (SCI) patients in Sri Lanka. SETTING:Ragama Rheumatology and Rehabilitation Hospital, Ragama, Sr...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.56
更新日期：2016-12-01 00:00:00
abstract：STUDY DESIGN:Prospective study. OBJECTIVE:To identify and define dermatological conditions following acute traumatic spinal cord injury (ATSCI) during inpatient rehabilitation. SETTING:Spinal Cord Injury Unit, The Department of Neurological Rehabilitation, The Chaim Sheba Medical Center, Israel. METHODS:During a 1-y...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3101697
更新日期：2005-03-01 00:00:00
abstract：STUDY DESIGN:A retrospective imaging and clinical study. OBJECTIVES:To evaluate the relationship between magnetic resonance imaging (MRI) features and neurological prognosis in patients with traumatic cervical spinal cord injury (CSCI) without major bone injury. METHODS:A total of 72 patients with CSCI without major ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.84
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:To assess the urodynamic and clinical outcome of a laparoscopic auto-augmentated bladder. METHODS:Laparoscopic bladder autoaugmentation in a 27-year-old woman with an incomplete spinal cord injury at T12 level with urge incontinence caused by a hyperreflexic bladder. RESULTS:Six months later the patient vo...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100939
更新日期：2000-01-01 00:00:00
abstract：STUDY DESIGN:Prospective clinical study. OBJECTIVES:This study aimed to translate, adapting to Brazilian version in Portuguese, validate and measure inter and intra-examinator reliability and internal consistency of the Thoracic-Lumbar Control Scale instrument. SETTING:State University of Campinas, São Paulo, Brazil....
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.86
更新日期：2011-12-01 00:00:00
