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Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome.

Abstract：

:Waardenburg anophthalmia syndrome, also known as microphthalmia with limb anomalies, ophthalmoacromelic syndrome, and anophthalmia-syndactyly, is a rare autosomal-recessive developmental disorder that has been mapped to 10p11.23. Here we show that this disease is heterogeneous by reporting on a consanguineous family, not linked to the 10p11.23 locus, whose two affected children have a homozygous mutation in SMOC1. Knockdown experiments of the zebrafish smoc1 revealed that smoc1 is important in eye development and that it is expressed in many organs, including brain and somites.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Abouzeid H,Boisset G,Favez T,Youssef M,Marzouk I,Shakankiry N,Bayoumi N,Descombes P,Agosti C,Munier FL,Schorderet DF

doi

10.1016/j.ajhg.2010.12.002

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

92-8

issue

1

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(10)00638-5

journal_volume

88

pub_type

杂志文章

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