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Mapping of complex traits by single-nucleotide polymorphisms.

Abstract：

:Molecular geneticists are developing the third-generation human genome map with single-nucleotide polymorphisms (SNPs), which can be assayed via chip-based microarrays. One use of these SNP markers is the ability to locate loci that may be responsible for complex traits, via linkage/linkage-disequilibrium analysis. In this communication, we describe a semiparametric method for combined linkage/linkage-disequilibrium analysis using SNP markers. Asymptotic results are obtained for the estimated parameters, and the finite-sample properties are evaluated via a simulation study. We also applied this technique to a simulated genome-scan experiment for mapping a complex trait with two major genes. This experiment shows that separate linkage and linkage-disequilibrium analyses correctly detected the signals of both major genes; but the rates of false-positive signals seem high. When linkage and linkage-disequilibrium signals were combined, the analysis yielded much stronger and clearer signals for the presence of two major genes than did two separate analyses.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Zhao LP,Aragaki C,Hsu L,Quiaoit F

doi

10.1086/301909

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

225-40

issue

1

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)60749-6

journal_volume

63

pub_type

杂志文章

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