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Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13.

Abstract：

:A recombinant DNA library enriched for portions of human chromosome 13 has been constructed from a hamster-human somatic cell hybrid that contained human chromosomes 13, 12, and 6p. A total of 733 phages were identified that contain human DNA inserts, and 46 single-copy subfragments have been derived and used as probes on Southern transfers of genomic DNA isolated from unrelated individuals. From this set, nine fragments revealing polymorphic loci (RFLP) in Msp I- or Taq I-digested DNA have been identified, of which three are polymorphic with both enzymes. Six of these probes have been shown to segregate concordantly with human chromosome 13 in a somatic cell hybrid mapping panel, and the RFLPs at these loci have been shown to behave as codominant Mendelian alleles. Additionally, hybridization to DNA isolated from cells containing various deletions of chromosome 13 has allowed regional localization. This recombinant DNA library will be useful in the study of retinoblastoma as well as in the study of the mechanisms responsible for abnormalities of this autosome.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Cavenee W,Leach R,Mohandas T,Pearson P,White R

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

10-24

issue

1

eissn

0002-9297

issn

1537-6605

journal_volume

36

pub_type

杂志文章

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