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Chromosomal localization of a human band 3-like gene to region 7q35----7q36.

Abstract：

:Band 3, the major transmembrane protein of erythrocytes, mediates the exchange of anions across the membrane and anchors the erythroid membrane skeleton. Proteins immunologically related to Band 3 have been detected in a variety of nonerythroid cells. We have isolated a human cDNA clone that encodes a protein related to but distinct from the erythroid form of Band 3, based on the comparison of the amino acid sequence for the two proteins. The presence of the gene for the Band 3-like protein in a panel of mouse-human somatic cell hybrids containing subsets of human chromosomes correlated with the presence of human chromosome 7. In situ hybridization analysis using the c-DNA for this nonerythroid Band 3 gene further localized the gene to region 7q35----7q36 of human metaphase chromosomes.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Palumbo AP,Isobe M,Huebner K,Shane S,Rovera G,Demuth D,Curtis PJ,Ballantine M,Croce CM,Showe LC

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

307-16

issue

3

eissn

0002-9297

issn

1537-6605

journal_volume

39

pub_type

杂志文章

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