Abstract：
:Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects on cytokines. Using three population-based cohorts (n = 9,263), we performed multivariate genome-wide association studies (GWAS) for a correlation network of 11 circulating cytokines, then combined our results in meta-analysis. We identified a total of eight loci significantly associated with the cytokine network, of which two (PDGFRB and ABO) had not been detected previously. In addition, conditional analyses revealed a further four secondary signals at three known cytokine loci. Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Nath AP,Ritchie SC,Grinberg NF,Tang HH,Huang QQ,Teo SM,Ahola-Olli AV,Würtz P,Havulinna AS,Santalahti K,Pitkänen N,Lehtimäki T,Kähönen M,Lyytikäinen LP,Raitoharju E,Seppälä I,Sarin AP,Ripatti S,Palotie A,Perola M,Vdoi
10.1016/j.ajhg.2019.10.001subject
Has Abstractpub_date
2019-12-05 00:00:00pages
1076-1090issue
6eissn
0002-9297issn
1537-6605pii
S0002-9297(19)30389-1journal_volume
105pub_type
杂志文章abstract：:Fertilization is a fundamental process of development and is a prerequisite for successful human reproduction. In mice, although several receptor proteins have been shown to play important roles in the process of fertilization, only three genes have been shown to cause fertilization failure and infertility when delete...
journal_title：American journal of human genetics
pub_type： 杂志文章
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journal_title：American journal of human genetics
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更新日期：1977-11-01 00:00:00
abstract：:Histochemical assay for ornithine transcarbamylase (OTC) activity in fixed frozen hepatic sections from a woman heterozygous for OTC deficiency revealed two populations of hepatocytes: those with normal activity and those with no activity. This observation, in conjunction with data from previous family studies, confir...
journal_title：American journal of human genetics
pub_type： 杂志文章
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更新日期：1976-07-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：10.1086/345801
更新日期：2003-01-01 00:00:00
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journal_title：American journal of human genetics
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journal_title：American journal of human genetics
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doi：
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章,评审
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：10.1086/301595
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journal_title：American journal of human genetics
pub_type： 杂志文章
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journal_title：American journal of human genetics
pub_type： 杂志文章
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
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journal_title：American journal of human genetics
pub_type： 杂志文章
doi：10.1016/j.ajhg.2011.04.001
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journal_title：American journal of human genetics
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doi：
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journal_title：American journal of human genetics
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journal_title：American journal of human genetics
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doi：
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journal_title：American journal of human genetics
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