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Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

Abstract：

:An analysis of the inherited pattern of C-band heterochromatin has been made in five pedigrees containing a total of 33 offspring that were available for analysis. The majority of variants were found to be inherited; however, at least seven of the 99 variants were not present in either parent, and an additional seven differed from the parental variant by either a morphological change or the appearance of mosaicism. It is believed that the polymorphism of human constitutive heterochromatin arises from a mismatching of the repetitive DNA sequences contained in these regions with subsequent unequal crossing over. Further, the observed mosaic patterns provide suggestive evidence that such an event occurs in somatic cells as well as during meiosis.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Craig-Holmes AP,Moore FB,Shaw MW

subject

Has Abstract

pub_date

1975-03-01 00:00:00

pages

178-89

issue

2

eissn

0002-9297

issn

1537-6605

journal_volume

27

pub_type

杂志文章

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