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Genome partitioning of genetic variation for height from 11,214 sibling pairs.

Abstract：

:Height has been used for more than a century as a model by which to understand quantitative genetic variation in humans. We report that the entire genome appears to contribute to its additive genetic variance. We used genotypes and phenotypes of 11,214 sibling pairs from three countries to partition additive genetic variance across the genome. Using genome scans to estimate the proportion of the genomes of each chromosome from siblings that were identical by descent, we estimated the heritability of height contributed by each of the 22 autosomes and the X chromosome. We show that additive genetic variance is spread across multiple chromosomes and that at least six chromosomes (i.e., 3, 4, 8, 15, 17, and 18) are responsible for the observed variation. Indeed, the data are not inconsistent with a uniform spread of trait loci throughout the genome. Our estimate of the variance explained by a chromosome is correlated with the number of times suggestive or significant linkage with height has been reported for that chromosome. Variance due to dominance was not significant but was difficult to assess because of the high sampling correlation between additive and dominance components. Results were consistent with the absence of any large between-chromosome epistatic effects. Notwithstanding the proposed architecture of complex traits that involves widespread gene-gene and gene-environment interactions, our results suggest that variation in height in humans can be explained by many loci distributed over all autosomes, with an additive mode of gene action.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Visscher PM,Macgregor S,Benyamin B,Zhu G,Gordon S,Medland S,Hill WG,Hottenga JJ,Willemsen G,Boomsma DI,Liu YZ,Deng HW,Montgomery GW,Martin NG

doi

10.1086/522934

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1104-10

issue

5

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)63884-1

journal_volume

81

pub_type

杂志文章

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