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A genetical model for vitiligo.

Abstract：

:A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Majumder PP,Das SK,Li CC

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

119-25

issue

2

eissn

0002-9297

issn

1537-6605

journal_volume

43

pub_type

杂志文章

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