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Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

Abstract：

:The genetic map in the region of human chromosome 7 that harbors the gene for cystic fibrosis (CF) has been refined by multilocus linkage studies in an expanded database including a large set of normal families. Six loci known to be linked to CF were examined: MET, an oncogene; COL1A2, collagen, TCRB, T-cell-receptor beta polypeptide; and three arbitrary loci--D7S8, D7S13, and D7S16--defined by probes pJ3.11, pB79a, and p7C22, respectively. The gene order with greatest statistical support is COL1A2-D7S13-D7S16-MET-D7S8-TCRB. Linkage analysis in families segregating for CF suggested that the most likely location of the CF gene on this map is between MET and D7S8.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Lathrop GM,Farrall M,O'Connell P,Wainwright B,Leppert M,Nakamura Y,Lench N,Kruyer H,Dean M,Park M

subject

Has Abstract,Author List Incomplete

pub_date

1988-01-01 00:00:00

pages

38-44

issue

1

eissn

0002-9297

issn

1537-6605

journal_volume

42

pub_type

杂志文章

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