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Absence of the Asian-specific region V mitochondrial marker in Native Beringians.

Abstract：

:The Asian-specific 9-bp deletion between the genes for mitochondrial cytochrome oxidase II and lysine transfer RNA has been used to trace aboriginal human movements out of Southeast Asia and into portions of the South Pacific. Although it has been used to estimate the number of independent lineages that occur in the New World, it has not been studied in native peoples of the Beringian region. Thus, we have used PCR to amplify and compare the lengths of DNA segments surrounding this deletion in native peoples of Beringia and the adjacent regions, as well as natives of the Altai Mountains of Southwestern Siberia. Of the 176 individuals analyzed here, the deletion was found in only 3 of 25 individuals from the Ust-Kan region of the Altai Mountains. We comment on the distribution of this marker and on potential relationships between Beringians and other Native American groups in which this marker has been surveyed. One Chukchi possessed three copies of the 9-bp sequence, which suggests (1) that the number of copies of this sequence in humans may be more variable than had been believed and (2) that a mechanism of replication based on tandem duplication may be a potential explanation for the origin of this length mutation in humans.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Shields GF,Hecker K,Voevoda MI,Reed JK

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

758-65

issue

4

eissn

0002-9297

issn

1537-6605

journal_volume

50

pub_type

杂志文章

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