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Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type I.

Abstract：

:Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African families with neurofibromatosis type 1 (NF1). The markers--p17H8, pHHH202, and EW204--were linked to NF1 at recombination fractions less than 1%. No evidence of locus heterogeneity was detected. Inspection of recombinant events in families informative for several markers suggests that the NF1 gene is located between the markers EW301 (cen-p11.2) and EW206 (cen-q12) and possibly distal to pHHH202 (q11.2-q12).

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Mathew CG,Thorpe K,Easton DF,Chin KS,Jadayel D,Ponder M,Moore G,Wallis CE,Slater CP,De Jong G

subject

Has Abstract,Author List Incomplete

pub_date

1989-01-01 00:00:00

pages

38-40

issue

1

eissn

0002-9297

issn

1537-6605

journal_volume

44

pub_type

杂志文章

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