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Widespread signals of convergent adaptation to high altitude in Asia and america.

Abstract：

:Living at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can also be due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex demographic histories. Our method can identify selection occurring at different scales, as well as convergent adaptation in different regions. We apply our approach to the analysis of a large SNP data set from low- and high-altitude human populations from America and Asia. The simultaneous analysis of these two geographic areas allows us to identify several candidate genome regions for altitudinal selection, and we show that convergent evolution among continents has been quite common. In addition to identifying several genes and biological processes involved in high-altitude adaptation, we identify two specific biological pathways that could have evolved in both continents to counter toxic effects induced by hypoxia.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Foll M,Gaggiotti OE,Daub JT,Vatsiou A,Excoffier L

doi

10.1016/j.ajhg.2014.09.002

subject

Has Abstract

pub_date

2014-10-02 00:00:00

pages

394-407

issue

4

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(14)00385-1

journal_volume

95

pub_type

杂志文章

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