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Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q.

Abstract：

:Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P<.00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P=.00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Slager SL,Schaid DJ,Cunningham JM,McDonnell SK,Marks AF,Peterson BJ,Hebbring SJ,Anderson S,French AJ,Thibodeau SN

doi

10.1086/368230

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

759-62

issue

3

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)60593-X

journal_volume

72

pub_type

杂志文章

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