Inflammatory manifestations at colonoscopy in patients with colonic diverticular disease.

Abstract:

BACKGROUND:Ulcerative colitis with diverticulosis (UCD), segmental colitis associated with diverticulosis (SCAD) and acute uncomplicated diverticulitis (AUD) may affect the same colonic regions, but the real incidence of these entities in clinical practice is unknown. AIM:To assess the incidence and the endoscopic findings of UCD, SCAD and AUD. METHODS:From January 2004 to June 2009, 8525 consecutive colonoscopies were performed. Diagnosis of the diseases was based on specific endoscopic and histological (UCD and SCAD), and on endoscopic and radiological (AUD) patterns. RESULTS:Ulcerative colitis with diverticulosis was diagnosed in 25 patients (0.3%), SCAD was diagnosed in 129 patients (2%) and AUD was diagnosed in 130 patients (2%). In UCD, the inflammation in colonic area harbouring diverticula always affects the overall colonic mucosa in all cases, involving also diverticular orifices. The endoscopic characteristic of SCAD is that inflammation is mainly detected within the inter-diverticular mucosa without involvement of the diverticular orifices. In AUD, the inflammation affects primarily diverticular orifice and peri-diverticular mucosa. CONCLUSIONS:In clinical practice, the incidence of mucosal inflammation in the presence of colonic diverticular disease is low and endoscopy is the mainstay of differential diagnosis.

journal_name

Aliment Pharmacol Ther

authors

Tursi A,Elisei W,Giorgetti GM,Aiello F,Brandimarte G

doi

10.1111/j.1365-2036.2010.04530.x

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

358-65

issue

3

eissn

0269-2813

issn

1365-2036

journal_volume

33

pub_type

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