Inflammatory manifestations at colonoscopy in patients with colonic diverticular disease.


BACKGROUND:Ulcerative colitis with diverticulosis (UCD), segmental colitis associated with diverticulosis (SCAD) and acute uncomplicated diverticulitis (AUD) may affect the same colonic regions, but the real incidence of these entities in clinical practice is unknown. AIM:To assess the incidence and the endoscopic findings of UCD, SCAD and AUD. METHODS:From January 2004 to June 2009, 8525 consecutive colonoscopies were performed. Diagnosis of the diseases was based on specific endoscopic and histological (UCD and SCAD), and on endoscopic and radiological (AUD) patterns. RESULTS:Ulcerative colitis with diverticulosis was diagnosed in 25 patients (0.3%), SCAD was diagnosed in 129 patients (2%) and AUD was diagnosed in 130 patients (2%). In UCD, the inflammation in colonic area harbouring diverticula always affects the overall colonic mucosa in all cases, involving also diverticular orifices. The endoscopic characteristic of SCAD is that inflammation is mainly detected within the inter-diverticular mucosa without involvement of the diverticular orifices. In AUD, the inflammation affects primarily diverticular orifice and peri-diverticular mucosa. CONCLUSIONS:In clinical practice, the incidence of mucosal inflammation in the presence of colonic diverticular disease is low and endoscopy is the mainstay of differential diagnosis.


Aliment Pharmacol Ther


Tursi A,Elisei W,Giorgetti GM,Aiello F,Brandimarte G




Has Abstract


2011-02-01 00:00:00












  • Review article: management of hepatic disease following haematopoietic cell transplant.

    abstract::Hepatic diseases are common complications of haematopoietic cell transplant. The causes are multiple: myeloablative conditioning regimens may cause sinusoidal injury; acute and chronic graft-versus-host disease lead to damaged hepatocytes and small bile ducts; microcrystalline deposits in the gall bladder can cause bi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: McDonald GB

    更新日期:2006-08-01 00:00:00

  • Low-dose lansoprazole and clarithromycin plus metronidazole vs. full-dose lansoprazole and clarithromycin plus amoxicillin for eradication of Helicobacter pylori infection.

    abstract:AIM:To compare, in a randomized controlled trial, the efficacy and tolerability of two 1-week triple therapies for Helicobacter pylori eradication. METHODS:One hundred and thirty-four consecutive patients with non-ulcer dyspepsia and H. pylori infection were randomized to receive lansoprazole 30 mg once daily, clarith...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bazzoli F,Zagari RM,Pozzato P,Fossi S,Ricciardiello L,Nicolini G,De Luca L,Berretti D,Alampi G,Di Pietro C,Morelli P,Roda E

    更新日期:2002-01-01 00:00:00

  • The use of adalimumab in the management of refractory Crohn's disease.

    abstract:BACKGROUND:Adalimumab is a humanized monoclonal antibody targeting tumour necrosis factor-alpha. Recent clinical trials have demonstrated its efficacy in Crohn's disease; however, experience in clinical practice remains limited. AIM:To investigate the efficacy and safety of adalimumab in the clinical setting. METHODS...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章


    authors: Ho GT,Smith L,Aitken S,Lee HM,Ting T,Fennell J,Lees CW,Palmer KR,Penman ID,Shand AG,Arnott ID,Satsangi J

    更新日期:2008-02-15 00:00:00

  • Characterisation of the gastrointestinal mucosa-associated microbiota: a novel technique to prevent cross-contamination during endoscopic procedures.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Shanahan ER,Zhong L,Talley NJ,Morrison M,Holtmann G

    更新日期:2016-06-01 00:00:00

  • Coeliac disease: a biopsy is not always necessary for diagnosis.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Hill PG,Holmes GK

    更新日期:2008-04-01 00:00:00

  • Serology-based criteria for adult coeliac disease have excellent accuracy across the range of pre-test probabilities.

    abstract:BACKGROUND:The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and coeliac disease-associated genetics. It remains unclear whether this approach is also applicable for adults with various clinical presentations. AIM:To evaluate the ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Fuchs V,Kurppa K,Huhtala H,Laurila K,Mäki M,Collin P,Salmi T,Luostarinen L,Saavalainen P,Kaukinen K

    更新日期:2019-02-01 00:00:00

  • Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Taha AS,Angerson WJ,Prasad R,McCloskey C,Gilmour D,Morran CG

    更新日期:2008-10-01 00:00:00

  • The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Zanten SJ,Bradette M,Farley A,Leddin D,Lind T,Unge P,Bayerdörffer E,Spiller RC,O'Morain C,Sipponen P,Wrangstadh M,Zeijlon L,Sinclair P

    更新日期:1999-03-01 00:00:00

  • The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.

    abstract:BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

    更新日期:2012-06-01 00:00:00

  • Histological benefits of virological response to peginterferon alfa-2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis.

    abstract:BACKGROUND:Patients with chronic hepatitis C virus and advanced fibrosis or cirrhosis are at risk for disease progression and hepatic decompensation. AIM:To determine the effects on hepatic histology of treatment with peginterferon alfa-2a (90 or 180 mug/week) or interferon alfa-2a (3 million units three times weekly)...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Everson GT,Balart L,Lee SS,Reindollar RW,Shiffman ML,Minuk GY,Pockros PJ,Govindarajan S,Lentz E,Heathcote EJ

    更新日期:2008-04-01 00:00:00

  • The incidence of inflammatory bowel disease in Denmark 1980-2013: a nationwide cohort study.

    abstract:BACKGROUND:Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM:To investigate trends ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Lophaven SN,Lynge E,Burisch J

    更新日期:2017-04-01 00:00:00

  • The risk of congenital abnormalities in children fathered by men treated with azathioprine or mercaptopurine before conception.

    abstract:BACKGROUND:Immunosuppressive therapy with azathioprine and mercaptopurine is commonly used in patients with various chronic diseases. The few existing data on the reproductive safety of these drugs after paternal use before conception are inconclusive. AIM:To examine the risk of congenital abnormalities in children fa...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Nørgård B,Pedersen L,Jacobsen J,Rasmussen SN,Sørensen HT

    更新日期:2004-03-15 00:00:00

  • The 12-month safety profile of dexlansoprazole, a proton pump inhibitor with a dual delayed release formulation, in patients with gastro-oesophageal reflux disease.

    abstract:BACKGROUND:Dexlansoprazole MR is a Dual Delayed Release formulation of dexlansoprazole, an enantiomer of lansoprazole, designed to extend the duration of acid suppression. AIM:To assess the 12-month safety of dexlansoprazole MR in patients with symptomatic gastro-oesophageal reflux disease (GERD). METHODS:In this ran...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dabholkar AH,Han C,Paris MM,Perez MC,Atkinson SN,Peura DA

    更新日期:2011-02-01 00:00:00

  • Depression in cirrhosis - a prospective evaluation of the prevalence, predictors and development of a screening nomogram.

    abstract:BACKGROUND:Depression is associated with substantial morbidity and mortality in cirrhosis, but is underdiagnosed and undertreated. AIMS:Using the Mini International Neuropsychiatric Interview (MINI) as a gold-standard, to determine prevalence, predictors, and outcomes of depression, and to develop a screening nomogram...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究


    authors: Buganza-Torio E,Mitchell N,Abraldes JG,Thomas L,Ma M,Bailey RJ,Tandon P

    更新日期:2019-01-01 00:00:00

  • Survival benefit of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma larger than 10 cm in diameter.

    abstract:BACKGROUND:The safety and survival benefit of transcatheter arterial chemoembolization for patients with huge hepatocellular carcinoma is uncertain. AIM:To evaluate the role of embolization in unresectable hepatocellular carcinomas larger than 10 cm. METHODS:Twenty-six consecutive patients who had an unresectable hep...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Huang YH,Wu JC,Chen SC,Chen CH,Chiang JH,Huo TI,Lee PC,Chang FY,Lee SD

    更新日期:2006-01-01 00:00:00

  • The impact of hepatitis C burden: an evidence-based approach.

    abstract:BACKGROUND:Infection with the hepatitis C virus (HCV) has been considered a major cause of mortality, morbidity and resource utilisation in the US. In addition, HCV is the main cause of hepatocellular cancer (HCC) in the US. Recent developments in the diagnosis and treatment of HCV, including new recommendations pertai...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Younossi ZM,Kanwal F,Saab S,Brown KA,El-Serag HB,Kim WR,Ahmed A,Kugelmas M,Gordon SC

    更新日期:2014-03-01 00:00:00

  • An analysis of the placebo effect in Crohn's disease over time.

    abstract:BACKGROUND:Randomized, placebo controlled trials are used to assess the efficacy of therapies for Crohn's disease. The placebo response and remission rates vary among studies. AIM:To analyse how the placebo response and remission rates in Crohn's trials have changed over time in the era of parenteral biologic therapie...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Gallahan WC,Case D,Bloomfeld RS

    更新日期:2010-01-01 00:00:00

  • Histamine receptor antagonists and incident colorectal adenomas.

    abstract:BACKGROUND:Prior studies suggest that histamines may modulate the development of colorectal neoplasia. AIM:To assess whether histamine receptor antagonist use was associated with adenoma formation. METHODS:Patients (n = 2366) were drawn from three adenoma chemoprevention trials. All underwent baseline colonoscopy wit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Robertson DJ,Burke CA,Schwender BJ,Wargovich MJ,Greenberg ER,Sandler RS,Ahnen DJ,Rothstein R,Mott LA,Baron JA

    更新日期:2005-07-15 00:00:00

  • The rising incidence of eosinophilic oesophagitis is associated with increasing biopsy rates: a population-based study.

    abstract:BACKGROUND:Eosinophilic oesophagitis (EoE) has evolved from a supposedly rare entity to one whose incidence rates are approaching that of inflammatory bowel disease. The factors responsible for this apparent increase in the incidence remain obscure. AIM:To assess various endoscopist and pathologist factors that might ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Syed AA,Andrews CN,Shaffer E,Urbanski SJ,Beck P,Storr M

    更新日期:2012-11-01 00:00:00

  • The safety of pegylated interferon alpha-2b in the treatment of chronic hepatitis B: predictive factors for dose reduction and treatment discontinuation.

    abstract:BACKGROUND:Treatment with interferon-alpha has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events. AIM:To investigate the safety of pegylated interferon alpha-2b in 300 hepatitis B e antigen-positive patients...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: van Zonneveld M,Flink HJ,Verhey E,Senturk H,Zeuzem S,Akarca US,Cakaloglu Y,Simon C,So TM,Gerken G,de Man RA,Hansen BE,Schalm SW,Janssen HL,HBV 99-01 Study Group.

    更新日期:2005-05-01 00:00:00

  • Quadruple therapy containing amoxicillin and tetracycline is an effective regimen to rescue failed triple therapy by overcoming the antimicrobial resistance of Helicobacter pylori.

    abstract:AIM:To identify optimal antibiotics for second-line quadruple therapy of Helicobacter pylori after failed 1-week triple therapy. METHODS:One hundred patients were enrolled in this study after the failure of 1-week triple therapy. They were randomized to receive 1-week quadruple therapy consisting of amoxicillin, omepr...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chi CH,Lin CY,Sheu BS,Yang HB,Huang AH,Wu JJ

    更新日期:2003-08-01 00:00:00

  • Review article: the epidemiology and therapy of chronic hepatitis C genotypes 4, 5 and 6.

    abstract:BACKGROUND:The global burden of hepatitis C (HCV) infection is mostly found in Africa, the Middle East and Asia, where HCV genotypes 4, 5 and 6 are common. The literature on these genotypes is sparse and this synopsis will review characteristics of patients infected with these genotypes. AIM:To review characteristics ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Wantuck JM,Ahmed A,Nguyen MH

    更新日期:2014-01-01 00:00:00

  • Mesenteric phlebosclerosis associated with long-term oral intake of geniposide, an ingredient of herbal medicine.

    abstract:BACKGROUND:Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. AIM:To investigate the possible association of herbal medicines with IMP. METHOD:The clinical data of...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Hiramatsu K,Sakata H,Horita Y,Orita N,Kida A,Mizukami A,Miyazawa M,Hirai S,Shimatani A,Matsuda K,Matsuda M,Ogino H,Fujinaga H,Terada I,Shimizu K,Uchiyama A,Ishizawa S,Abo H,Demachi H,Noda Y

    更新日期:2012-09-01 00:00:00

  • Clinical trial: comparison of the gastrointestinal safety of lumiracoxib with traditional nonselective nonsteroidal anti-inflammatory drugs early after the initiation of treatment--findings from the Therapeutic Arthritis Research and Gastrointestinal Even

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Hawkey CJ,Weinstein WM,Stricker K,Murphy V,Richard D,Krammer G,Rebuli R

    更新日期:2008-05-01 00:00:00

  • Drug interactions with antisecretory agents.

    abstract::Antisecretory agents may affect the absorption, metabolism, and renal excretion of other drugs. Inhibition of gastric acid secretion may decrease the gastrointestinal absorption of drugs such as ketoconazole that dissolve poorly in the absence of adequate acid. With anti-secretory agents, the drug interaction mechanis...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Hansten PD

    更新日期:1991-01-01 00:00:00

  • Earlier discontinuation of TNF-α inhibitor therapy in female patients with inflammatory bowel disease is related to a greater risk of side effects.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Schultheiss JPD,Brand EC,Lamers E,van den Berg WCM,van Schaik FDM,Oldenburg B,Fidder HH

    更新日期:2019-08-01 00:00:00

  • Systematic review: the hepatotoxicity of non-steroidal anti-inflammatory drugs.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury. However, the precise risk of non-steroidal anti-inflammatory drugs for this rare complication is unknown. AIM:To review systematically the published literature of population-based epidemiological studies reporting the inc...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Rubenstein JH,Laine L

    更新日期:2004-08-15 00:00:00

  • Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Qua CS,Wong CH,Gopala K,Goh KL

    更新日期:2007-02-01 00:00:00

  • Prediction of Crohn's disease relapse with faecal calprotectin in infliximab responders: a prospective study.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Laharie D,Mesli S,El Hajbi F,Chabrun E,Chanteloup E,Capdepont M,Razaire S,de Lédinghen V,Zerbib F

    更新日期:2011-08-01 00:00:00

  • Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV-infected, evaluated patients.

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    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Talal AH,LaFleur J,Hoop R,Pandya P,Martin P,Jacobson I,Han J,Korner EJ

    更新日期:2013-02-01 00:00:00