当前位置： SCI文献检索 > Gaceta Sanitaria期刊下所有文献 > [Influence of substitution of brand name for generic drugs on therapeutic compliance in hypertension and dyslipidemia].

[Influence of substitution of brand name for generic drugs on therapeutic compliance in hypertension and dyslipidemia].

Abstract：

OBJECTIVE:To determine therapeutic compliance when brand name amlodipine and simvastatin are substituted for generic drugs, and to determine patients' and physicians' opinions of this substitution. PATIENTS AND METHODS:We performed an observational study with a control group, based on a review of the medical records in six primary care centers. Participants consisted of patients ≥ 40 years old initiating treatment with a brand name drug (initial period), which was later substituted by a generic drug (final period). The study subgroups consisted of patients with hypertension (amlodipine) or dyslipidemia (simvastatin). The main measures were comorbidity, compliance, treatment length, biochemistry determinations, and patients' and physicians' opinions (interviews). All patients received a brand name drug for a minimum of 1 year followed by a generic drug for a minimum of 1 year (minimum continuation/patient: 24 months). RESULTS:There were 1,252 patients (groups: 49.5% amlodipine; 50.5% simvastatin). Patients treated with amlodipine (period comparison) showed better compliance (65.8 vs. 61.3%; p=0.037) and blood pressure control (48.5 vs. 45.8%; p=0.039) with the brand name drug. The percentages with simvastatin were 62.8 vs. 58.4% (p=0.041), respectively. A total of 73.6% of the physicians interviewed prescribed generic drugs and 59.2% believed that both types of drug had the same efficacy. Most of the patients interviewed (79.8%; CI: 74.3-85.3%) accepted the substitution; 55.3% (CI: 48.5-62.1%) received the appropriate information but 61.5% were confused by the different products. Lack of compliance was reported by 18.2%. CONCLUSIONS:In patients receiving amlodipine or simvastatin, compliance decreased with time, independently of the change from a band name to a generic drug.

journal_name

Gac Sanit

journal_title

Gaceta sanitaria

authors

Mainar AS,Artieda RN

doi

10.1016/j.gaceta.2010.07.007

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

473-82

issue

eissn

0213-9111

issn

1578-1283

pii

S0213-9111(10)00193-7

journal_volume

pub_type

杂志文章,多中心研究

在线工具

[Influence of substitution of brand name for generic drugs on therapeutic compliance in hypertension and dyslipidemia].