Abstract：
OBJECTIVE:This study identified factors in patients with diabetes associated with risk of developing dementia. RESEARCH DESIGN AND METHODS:This retrospective, longitudinal study used a national cohort of US Veterans with diabetes 65 years or older to examine incidence of dementia over 2 years. A multivariable Cox regression model was used to estimate risk of developing dementia associated with sociodemographic factors, use of diabetes medications, and duration of diabetes. RESULTS:In all, 377,838 patients (average age, 75.53 ± 6.07 years) were studied. Over the 2 year follow-up, 14,580 (3.85%) were diagnosed with dementia. Major risk factors for dementia were age >75 years (75-85 years, hazard ratio [HR] 2.092, 95% confidence interval [CI] 2.017-2.169; ≥85 years, HR 3.468, CI 3.274-3.672), race black versus white, HR 1.218, CI 1.164-1.274), Southern residence (HR = 1.181, CI 1.133-1.232), and diabetes duration (HR for 5 years or more, 1.428, CI 1.357-1.504). There was a reduced HR for dementia with use of an oral hypoglycemic agent (HR 0.940, CI 0.909-0.972) and HMG-CoA reductase inhibitors (HR, 0.875, CI 0.846-0.906). There was no change in HR with insulin use (HR 1.024, CI 0.983-1.067). CONCLUSIONS:Several important factors were identified that are associated with increased dementia risk, and two factors were identified that are associated with reduced risk. It will be important to ascertain whether risk-factor modification reduces the HR for dementia in persons with diabetes, and to further examine effects of medication use for comorbid conditions.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Parikh NM,Morgan RO,Kunik ME,Chen H,Aparasu RR,Yadav RK,Schulz PE,Johnson MLdoi
10.1002/gps.2604subject
Has Abstractpub_date
2011-07-01 00:00:00pages
749-57issue
7eissn
0885-6230issn
1099-1166journal_volume
26pub_type
杂志文章abstract：AIM:To evaluate the influence of premorbid personality on adaptation to placement in a long-term care facility. SUBJECTS:Twenty-eight persons with probable Alzheimer disease (AD) residing in an academically affiliated nursing home for 6-9 months. METHODS:Premorbid personality was described retrospectively by two info...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199808)13:8<509::aid-gps80
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. Orally administered ChEIs may be associated with gastrointestinal (GI) side effects and add-on therapy with memantine, an N...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.2355
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Cerebromicrovascular disease (CMVD) strikes 87% of the population older than 65 years and is linked to an increased risk of ischemic stroke, depression, cognitive impairment, and Alzheimer's disease. Despite the wealth of knowledge on the consequences to the body stemming from poor vascular health, little fo...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4046
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVES:To examine the clinical differences between late-onset schizophrenia (LOS) and early-onset schizophrenia (EOS) in Taiwanese elderly chronic hospitalized schizophrenic patients. METHODS:By using a cross-sectional study method, we investigated all the hospitalized elderly schizophrenic patients in a general h...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2241
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Despite modest efficacy, unpredictable individual utility, and a high rate of adverse effects, behavioural and psychological symptoms of dementia (BPSD) are common determinants for antipsychotic drug therapy in nursing home patients. AIMS:To explore the impact on BPSD of stopping long-term antipsychotic tre...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.1998
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the prevalence, clinical features, and comorbidities of restless legs syndrome (RLS) among psychogeriatric patients in an out-patient clinical setting. METHODS:Cross-sectional study of a sample of 100 non-demented psychogeriatric outpatients that were assessed for the presence of RLS using the Re...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2674
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4353
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To establish the factor structure, reliability and validity of a brief CESD scale among Community dwelling older adults in Singapore. METHOD:Data were derived from interviews conducted among 1,013 randomly selected non-institutionalized older adults aged 65 years and above in Singapore. First, Confirmatory F...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1944
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Deliberate self harm (DSH) in later life is under researched and is believed to be related to both mental illness and suicide. AIMS:The aim of the study was to examine deliberate self-harm (DSH) in older people presenting to acute hospital services over three years. METHOD:This was a retrospective observat...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1404
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Vitamin B12 assay is part of the routine investigation of dementia, although few studies have investigated the effects of treatment on cognition. We examined the effects of B12 treatment on neuropsychological function and disease progression in patients presenting with dementia or cognitive impairment. METH...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200003)15:3<226::aid-gps98
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5325
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4875
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVES:Describe novel methods for ascertaining verbal fluency in a large national sample of adults, examine demographic factors influencing performance, and compare scores to studies using in-person assessment. METHODS/DESIGN:Participants were from the Reasons for Geographic and Racial Differences in Stroke (REGAR...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5054
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the impact of nortriptyline to sertraline on change in cognitive functioning in depressed older adults. METHODS:We used pre-post neuropsychological data collected as part of a 12-week medication trial comparing sertraline to nortriptyline in the treatment of older adults ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.2783
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/gps.1048
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:To identify which specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression. METHODS:This is a secondary analysis of data from a late-life treatment resistant depression trial examining the safety and efficacy of aripiprazole augmentation. Partici...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.4813
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Several studies have found that low grip strength is associated with dementia in Western populations. However, there have been few studies in Asian populations. This cross-sectional study aimed to examine whether grip strength is independently associated with dementia after controlling for other related fact...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2742
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:This study aims to determine the long-term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome. METHODS:In a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for dep...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.4010
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Despite the fact that the current definitions of dementia in the DSM-IV and ICD-10 require functional deterioration for the diagnosis of dementia, it is not necessary a formal evaluation of functional capacity. OBJECTIVES:To examine the efficiency of functional assessment as a method of screening dementia i...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1002/gps.1747
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To evaluate variables associated with quality of life (QOL) in dementia residents in a long-term care facility using a recently standardized and validated dementia-specific QOL scale (ADRQL). METHOD:A cross-sectional, case-control design was employed using validated scales to assess dementia-related symptoma...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200002)15:2<181::aid-gps96
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVES:Little research has explored how cognitive function and activities of daily living (ADL) affect each other over time. In addition, no current finding provides a clear hint to the temporal precedence between them. The present study tries to address these limitations of prior studies by utilizing a longitudina...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5206
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:Short-form versions of the Montreal Cognitive Assessment (SF-MoCA) are increasingly used to screen for dementia in research and practice. We sought to collate evidence on the accuracy of SF-MoCAs and to externally validate these assessment tools. METHODS:We performed systematic literature searching across...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5162
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:This study investigated the reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale (CDR-CC). METHOD:Sixty-two residents in a chronic care facility participated in an inter-rater and 1 month test-retest reliability study. The instrument was validated against the M...
journal_title：International journal of geriatric psychiatry
pub_type： 社论
doi：10.1002/gps.385
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVES:The ventrolateral prefrontal cortex (vlPFC) has been speculated to play an important role in complex processes that allow emotional factors to influence human cognition. Accumulating evidence from human neuroimaging studies, in conjunction with studies of patients with lesions and animal models, shed light o...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4982
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:The IDEAL Schedule was developed for staging "care needs" in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for "care needs". METHODS:A multicenter study was done in 8 dementia care facilities across Spain. Patients...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.4781
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). METHODS:Neuropsychiatric symptoms during the month prior to assessment were assessed in clinically diagnosed PD...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.389
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVES:The objectives of the study are to investigate how different levels of functional ability relate to quality of life, well-being, and satisfaction with life, conceptualised as reflecting capability to "live well" in people with dementia. METHODS/DESIGN:Participants were 1496 people with mild-to-moderate deme...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5128
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:This study is part of the Research to Assess Policies and Strategies for Dementia in the Young project. Information about specific needs in young onset dementia (YOD) will provide the basis for the development of an e-health intervention to assist caregivers in coping with YOD in several European countries. ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4749
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Studies have shown that psychological problems in elderly patients are often unrecognised in primary care. The aim of this study was to investigate the quality of life and consultation rates of Chinese elderly patients with unrecognised psychological problems in primary care. The prevalence and risk factors o...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.2210
更新日期：2009-09-01 00:00:00
abstract：RESEARCH OBJECTIVE:Estimates of the prevalence of major depression vary widely. Current estimates range from 2 to 14 % depending upon the definition and procedure for diagnosis. Further, most estimates are for special populations, either living in selected geographic areas or receiving specific types of medical care. A...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.642
更新日期：2002-06-01 00:00:00
