Abstract:
:The metabolic pathway of butylated hydroxytoluene (BHT) to the ring-oxygenated metabolites 2,6-di-tert-butylhydroquinone (BHQ) and 2,6-di-tert-butyl-p-benzoquinone (BBQ) was examined in rats. After intraperitoneal administration of 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-acid), which had been regarded as one of the major metabolic end-products of BHT, 2,6-di-tert-butylphenol (DBP) and BBQ were identified in the feces by gas chromatography and gas chromatography-mass spectrometry (GC-MS). The biliary excretion of BBQ, BHQ glucuronide and BHT-acid glucuronide was also confirmed by GC-MS and high-performance liquid chromatography methods. The excretion rate of BHQ glucuronide for 24h after dosing with BHT-acid was about 9-fold higher than that after dosing with BHT. In addition, the formation of BBQ was confirmed in the urine after dosing with DBP. These results suggest that BHT is metabolized to BHQ and BBQ through DBP formed by decarboxylation of BHT-acid.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Yamamoto K,Tajima K,Takemura M,Mizutani Tdoi
10.1248/cpb.39.512subject
Has Abstractpub_date
1991-02-01 00:00:00pages
512-4issue
2eissn
0009-2363issn
1347-5223journal_volume
39pub_type
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