Abstract:
:A new flavonol, morin-3-O-alpha-rhamnopyranoside (1), along with four known flavonols, kaempferol 3-O-alpha-rhamnopyranoside (2), kaempferol 3-O-beta-glucopyranoside (3), quercetin 3-O-alpha-rhamnopyranoside (4) and (+)-catechin (5), were isolated from the methanolic extract of Muehlenbeckia platyclada. The structures of these compounds were determined on the basis of chemical and spectroscopic evidence, as well as acid hydrolysis of the original glycoside. Isolates were evaluated for inhibition of generation of superoxide anion, and inhibition of release of neutrophil elastase. Compound 2 showed moderate inhibition of superoxide anion generation with an IC(50) value of 6.11+/-0.86 microg/ml; 1, 3 and 5 inhibited neutrophil elastase release with IC(50) values of 3.82+/-0.80, 8.61+/-1.38 and 4.37+/-0.72 microg/ml, respectively, and were 15-fold more potent than phenylmethylsulfonyl fluoride (PMSF), the positive control, in this anti-inflammatory assay.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Yen CT,Hsieh PW,Hwang TL,Lan YH,Chang FR,Wu YCdoi
10.1248/cpb.57.280subject
Has Abstractpub_date
2009-03-01 00:00:00pages
280-2issue
3eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.280journal_volume
57pub_type
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