Are endometrial polyps true cancer precursors?

Abstract:

OBJECTIVE:The purpose of this study was to assess whether endometrial polyps (EMPs) represent cancer precursors. STUDY DESIGN:Age standardized incidence ratios (SIRs) of histologically verified endometrial cancers (EmCas) were estimated in women with EMPs and in women with uterine leiomyomata, which is a condition that is unrelated to endometrial carcinogenesis. SIRs were calculated as the ratio of observed to expected EmCas based on age-specific incidence rates for female Montreal residents during the same period. RESULTS:Of 1467 women with EMPs, 125 (8.5%) had EmCa. Of 1138 patients with uterine leiomyomata, 133 (11.7%) had EmCa. The SIRs of EmCa for women with EMPs (odds ratio, 8.0; 95% confidence interval, 6.6-9.5) were significantly lower than that in women with leiomyomata (odds ratio, 19.1; 95% confidence interval, 16.0-22.6). Abnormal uterine bleeding was the main reason for evaluating patients with EMP with or without associated EmCa. CONCLUSION:The findings of higher EmCa incidence are consistent with enhanced detection opportunity rather than with the endometrial cancer precursor potential of EMPs.

journal_name

Am J Obstet Gynecol

authors

Perri T,Rahimi K,Ramanakumar AV,Wou K,Pilavdzic D,Franco EL,Gotlieb WH,Ferenczy A

doi

10.1016/j.ajog.2010.03.036

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

232.e1-6

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)00355-8

journal_volume

203

pub_type

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