Abstract：
BACKGROUND:There is a debate in the literature whether a pathologic nipple discharge is a distinct sign of breast carcinoma. Our own results obtained by the use of microdochectomy as a minimally invasive operative procedure in 184 patients with pathologic nipple discharge were analysed. The aim of this retrospective 20-year study was to assess the efficacy of microdochectomy in detecting early stages of intraductal breast carcinoma. PATIENTS AND METHODS:The study included data on 184 patients aged 24-77 years (median 46.6) divided into two groups of premenopausal (n = 123) and postmenopausal (n = 61) women. There were 139 patients with unilateral single-duct sanguinolent discharge and 45 patients with other types of nipple discharge. The operative procedure consisted of the discharging duct excision by use of a guide probe, preceded by cytology and ductography studies. RESULTS:Histopathology of the excised ducts revealed only three carcinomas in premenopausal women and ten carcinomas in postmenopausal women. In a total of 13 carcinomas, there were 4 ductal carcinomas in situ, detected in patients aged 41-72 (median 66) years. Twelve carcinomas were associated with sanguinolent nipple discharge. Papilloma was the most common histology finding (56.5%). CONCLUSION:Results of the study suggested mainly the association of sanguinolent single-duct nipple discharge and papilloma, whereas the rate of malignancies detected (7.0%) was consistent with literature reports. Microdochectomy proved to be a highly efficient operative method free from any impairment of the breast integrity. Conservative treatment with close clinical monitoring of the patient with cytology and ultrasonographic assessment might be possible in selected cases.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Fajdić J,Gotovac N,Glavić Z,Hrgović Z,Jonat W,Schem Cdoi
10.1007/s00404-010-1481-6subject
Has Abstractpub_date
2011-04-01 00:00:00pages
851-4issue
4eissn
0932-0067issn
1432-0711journal_volume
283pub_type
杂志文章abstract：PURPOSE:Mastectomy without axillary dissection should be the standard treatment in patients with malignant form of cystosarcoma phyllodes. The role of postoperative radiotherapy and chemotherapy remains to be fully established. We evaluate treatment results in a group of patients with cystosarcoma phyllodes (CP) treate...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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doi：10.1007/s00404-017-4600-9
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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doi：10.1007/s00404-015-3642-0
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,多中心研究
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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abstract：INTRODUCTION:Radiotherapy is known to cause rarely various malignancies including leukemia, sarcoma, and thyroid and lung carcinoma. Post-radiation sarcomas account for 0.5-5.5% of all sarcomas; and include extra skeletal osteosarcoma, fibrosarcoma leiomyosarcoma, and malignant fibrous histiocytoma. Reports on post rad...
journal_title：Archives of gynecology and obstetrics
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doi：10.1007/s00404-010-1699-3
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05333-3
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3596-7
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