Computer-based assessment of cognitive functions in brain tumor patients.

abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

journal_title：Journal of neuro-oncology

authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

更新日期：2006-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with GBM is poor, having a median survival rate of 12-15 months. Despite modern advances in the development of antineoplastic agents, the efficacy of newer anti-cance...

journal_title：Journal of neuro-oncology

authors： Gurley SN,Abidi AH,Allison P,Guan P,Duntsch C,Robertson JH,Kosanke SD,Keir ST,Bigner DD,Elberger AJ,Moore BM 2nd

更新日期：2012-11-01 00:00:00

abstract：:A 9-day-old female presented with a large infra- and supratentorial medulloblastoma was treated by surgery, irradiation and chemotherapy. The infant suffered from vomit a few days after birth. She was hospitalized shortly thereafter, when head enlargement was noted. A CT scan taken on admission disclosed a large mass ...

journal_title：Journal of neuro-oncology

authors： Kayama T,Yoshimoto T,Shimizu H,Sakurai Y

更新日期：1993-02-01 00:00:00

abstract：:Anguidine pretreatment was previously shown to potentiate cis-platinum in Chinese hamster ovary cells by 100-fold, probably by enhancing cellular cis-platinum uptake. Since both cis-platinum and anguidine have been reported to have clinical efficacy in human brain tumors, the present study was initiated to investigate...

journal_title：Journal of neuro-oncology

authors： Hromas RA,Yung WK

更新日期：1986-01-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

journal_title：Journal of neuro-oncology

authors： Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

更新日期：2018-06-01 00:00:00

abstract：:Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular to...

journal_title：Journal of neuro-oncology

authors： Jain R,Narang J,Sundgren PM,Hearshen D,Saksena S,Rock JP,Gutierrez J,Mikkelsen T

更新日期：2010-10-01 00:00:00

abstract：:There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors o...

journal_title：Journal of neuro-oncology

authors： Brodeur GM,Nakagawara A,Yamashiro DJ,Ikegaki N,Liu XG,Azar CG,Lee CP,Evans AE

更新日期：1997-01-01 00:00:00

abstract：:Glioblastoma multiforme is a primary brain tumor associated with extensive invasion into surrounding brain tissue. Matrix metalloproteinases (MMPs) and urokinase plasminogen activation (uPA) system are shown to be involved in tumor invasion as they help in degradation of extracellular matrix (ECM) proteins and thus as...

journal_title：Journal of neuro-oncology

authors： Puli S,Lai JC,Bhushan A

更新日期：2006-09-01 00:00:00

abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

journal_title：Journal of neuro-oncology

authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS:We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. F...

journal_title：Journal of neuro-oncology

authors： Kim N,Lee CG,Kim EH,Kim CH,Keum KC,Lee KS,Chang JH,Suh CO

更新日期：2019-01-01 00:00:00

abstract：:Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventi...

journal_title：Journal of neuro-oncology

authors： Ducray F,del Rio MS,Carpentier C,Psimaras D,Idbaih A,Dehais C,Kaloshi G,Mokhtari K,Taillibert S,Laigle-Donadey F,Omuro A,Sanson M,Delattre JY,Hoang-Xuan K

更新日期：2011-02-01 00:00:00

abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...

journal_title：Journal of neuro-oncology

authors： Zhang J,Lv J,Zhang F,Che H,Liao Q,Huang W,Li S,Li Y

更新日期：2017-07-01 00:00:00

abstract：:Astrocytic neoplasms are genetically heterogeneous; however a low frequency of genomic changes has been found in juvenile pilocytic astrocytoma (PA) in molecular studies. Concerning pleomorphic xanthoastrocytomas (PXA), recent studies have given heterogeneous results for chromosomal alterations. We studied the subtelo...

journal_title：Journal of neuro-oncology

authors： Grau E,Balaguer J,Canete A,Martinez F,Orellana C,Oltra S,Hernandez M,Castel V

更新日期：2009-06-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), wit...

journal_title：Journal of neuro-oncology

authors： Todaro L,Christiansen S,Varela M,Campodónico P,Pallotta MG,Lastiri J,Sacerdote de Lustig E,Bal de Kier Joffé E,Puricelli L

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Stereotactic radiosurgery is an established treatment option for sporadic meningiomas, though limited data exists for radiation-induced lesions. METHODS:Patients treated with cobalt-60 radiosurgery between October 2005 and December 2018 in an institutional registry were reviewed. Single fraction treatments wer...

journal_title：Journal of neuro-oncology

authors： Huo M,Laperriere N,van Prooijen M,Shultz D,Coolens C,Hodaie M,Cusimano M,Gentili F,Zadeh G,Payne D,Schwartz M,Tsang DS

更新日期：2020-06-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant...

journal_title：Journal of neuro-oncology

authors： Pan YB,Zhang CH,Wang SQ,Ai PH,Chen K,Zhu L,Sun ZL,Feng DF

更新日期：2018-04-01 00:00:00

abstract：:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

journal_title：Journal of neuro-oncology

authors： Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

更新日期：2005-01-01 00:00:00

abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

journal_title：Journal of neuro-oncology

authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

更新日期：2018-07-01 00:00:00

abstract：:Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...

journal_title：Journal of neuro-oncology

authors： Kim WH,Yoon SH,Kim CY,Kim KJ,Lee MM,Choe G,Kim IA,Kim JH,Kim YJ,Kim HJ

更新日期：2011-01-01 00:00:00

abstract：:Our objective was to explore the impact of the histopathological tumor type on affective symptoms before surgery among male and female patients with supratentorial primary brain tumors. A total of 44 adult patients were included in the study. Depression and anxiety were measured using the Beck Depression Inventory (BD...

journal_title：Journal of neuro-oncology

authors： Richter A,Jenewein J,Krayenbühl N,Woernle C,Bellut D

更新日期：2016-01-01 00:00:00

abstract：:Patients with high grade glioma generally have poor prognoses. Addition of radiosensitizing agents might improve the response to irradiation. The chemotherapeutic agent estramustine sensitizes experimental gliomas to radiation. Gliomas express estramustine binding proteins, and cytotoxic concentrations of estramustine...

journal_title：Journal of neuro-oncology

authors： Landy H,Markoe A,Potter P,Lasalle G,Marini A,Savaraj N,Reis I,Heros D,Wangpaichitr M,Feun L

更新日期：2004-03-01 00:00:00

abstract：:ERCC1 and ERCC2 have been known to belong to the nucleotide excision repair (NER) pathway and are essential to the repair of cisplatin DNA adducts. In the present study, we have examined the potential correlation of ERCC1, ERCC2 mRNA expression and single nucleotide polymorphism (SNP) to chemotherapy drug cytotoxicity...

journal_title：Journal of neuro-oncology

authors： Chen H,Shao C,Shi H,Mu Y,Sai K,Chen Z

更新日期：2007-05-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...

journal_title：Journal of neuro-oncology

authors： Hsu SS,Chen CH,Liu GS,Tai MH,Wang JS,Wu JC,Kung ML,Chan EC,Liu LF

更新日期：2012-03-01 00:00:00

abstract：:Increasing interest has developed in the use of the photodynamic agent, Hematoporphyrin derivative (HpD) for photoradiation therapy (PRT) as adjunctive therapy of malignant glial tumors of the brain. HpD, injected systemically, is preferentially taken up and retained by neoplastic tissue. Early studies of such uptake ...

journal_title：Journal of neuro-oncology

authors： Little FM,Gomer CJ,Hyman S,Apuzzo ML

更新日期：1984-01-01 00:00:00

abstract：:Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Cooke JRN,Ellis JA,Emala CW,Bruce JN

更新日期：2017-12-01 00:00:00

abstract：:Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

journal_title：Journal of neuro-oncology

authors： Aguilar LK,Aguilar-Cordova E

更新日期：2003-12-01 00:00:00

abstract：:Overexpression of the EGFR, IGFBP-2 and HIF-2A genes has been observed in high-grade astrocytomas and these genes seem to be functionally related to one another. This study aimed to define the profile of their expressions, interactions and correlation with clinical features and prognostic significance in microdissecte...

journal_title：Journal of neuro-oncology

authors： Scrideli CA,Carlotti CG Jr,Mata JF,Neder L,Machado HR,Oba-Sinjo SM,Rosemberg S,Marie SK,Tone LG

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development ...

journal_title：Journal of neuro-oncology

authors： Olsson A,Bouaoun L,Auvinen A,Feychting M,Johansen C,Mathiesen T,Melin B,Lahkola A,Larjavaara S,Villegier AS,Byrnes G,Deltour I,Schüz J

更新日期：2019-01-01 00:00:00

abstract：:The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 200...

journal_title：Journal of neuro-oncology

authors： Sadetzki S,Chetrit A,Turner MC,van Tongeren M,Benke G,Figuerola J,Fleming S,Hours M,Kincl L,Krewski D,McLean D,Parent ME,Richardson L,Schlehofer B,Schlaefer K,Blettner M,Schüz J,Siemiatycki J,Cardis E

更新日期：2016-12-01 00:00:00