Abstract:
:Two patients with acute immune haemolytic anaemia caused by diclofenac are described. Both patients had developed IgG drug-independent autoantibodies and drug-dependent antibodies. The drug-dependent antibodies in one patient reacted with red blood cells (RBC) only in the presence of urine from patients receiving diclofenac (ex vivo antigen) but not in the presence of the drug itself or its known metabolites. This antibody appeared to recognize a trace metabolite which has not yet been identified. The drug-dependent antibodies in the second patient reacted with RBC in the presence of urine as ex vivo antigen as well as in the presence of the drug itself and its main metabolites. Incorrect diagnosis of such cases often is due to the occurrence of autoantibodies and/or unusual drug metabolism and excretion.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Salama A,Göttsche B,Mueller-Eckhardt Cdoi
10.1111/j.1365-2141.1991.tb08624.xsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
546-9issue
4eissn
0007-1048issn
1365-2141journal_volume
77pub_type
杂志文章abstract::This work aimed to provide a means of assaying directly the effects of transient expression of introduced genes on the survival, proliferation, lineage commitment and differentiation of haemopoietic progenitor cells. For this purpose, we have developed a system that allows isolation of productively transfected, muliti...
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journal_title:British journal of haematology
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pub_type: 杂志文章
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