Abstract:
:Population genetics has evolved from a theory-driven field with little empirical data into a data-driven discipline in which genome-scale data sets test the limits of available models and computational analysis methods. In humans and a few model organisms, analyses of whole-genome sequence polymorphism data are currently under way. And in light of the falling costs of next-generation sequencing technologies, such studies will soon become common in many other organisms as well. Here, we assess the challenges to analyzing whole-genome sequence polymorphism data, and we discuss the potential of these data to yield new insights concerning population history and the genomic prevalence of natural selection.
journal_name
Genome Resjournal_title
Genome researchauthors
Pool JE,Hellmann I,Jensen JD,Nielsen Rdoi
10.1101/gr.079509.108subject
Has Abstractpub_date
2010-03-01 00:00:00pages
291-300issue
3eissn
1088-9051issn
1549-5469pii
gr.079509.108journal_volume
20pub_type
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