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A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.

Abstract：

:A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Chimenti F,Fioravanti R,Bolasco A,Chimenti P,Secci D,Rossi F,Yáñez M,Orallo F,Ortuso F,Alcaro S,Cirilli R,Ferretti R,Sanna ML

doi

10.1016/j.bmc.2009.12.029

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

1273-9

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)01113-4

journal_volume

18

pub_type

杂志文章

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