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Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors.

Abstract：

:Three new derivatives of 2-substituted 1,3,4-thiadiazole-5-sulfonamide have been synthesized. These compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide (1); 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide (2); and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide (3). Inhibition effects of these compounds on carbonic anhydrase I and II have been investigated. By comparing I50 and Ki values of the compounds, it has been found that compound 1 is a more potent inhibitor than acetazolamide (b) on carbonic anhydrase II.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Arslan O,Küfrevioĝlu OI,Nalbantoĝlu B

doi

10.1016/s0968-0896(96)00272-6

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

515-8

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968089696002726

journal_volume

5

pub_type

杂志文章

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