Abstract:
BACKGROUND:Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference. AIM:This study was to investigate the potential association between the SERT-P polymorphism and clinical subtypes of IBS patients in the Indian population. METHOD:This prospective case-control study included 151 IBS patients. Ninety-two patients were diarrhea-predominant IBS, 44 were constipation-predominant IBS (C-IBS), 15 were alternating diarrhea and constipation IBS, and 100 were healthy controls. SERT gene polymorphism was studied by polymerase chain reaction. RESULT:A genotypic association was observed between SS genotype of SERT-P polymorphism and C-IBS (P<0.05). When the L/S and L/L genotypes were combined into one group, the frequency of the S/S genotype was significantly higher than that of the non-S/S genotype between C-IBS and the control group (P<0.05). There was no significant difference in the SERT-P genotype and allele frequency between c-ibs, alternating diarrhea and constipation IBS, all types of IBS cases, and controls. CONCLUSIONS:A significant association was observed between the SS genotype of SERT-P polymorphism and C-IBS in the Indian population.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Sikander A,Rana SV,Sinha SK,Prasad KK,Arora SK,Sharma SK,Singh Kdoi
10.1097/MCG.0b013e3181b37e8csubject
Has Abstractpub_date
2009-11-01 00:00:00pages
957-61issue
10eissn
0192-0790issn
1539-2031journal_volume
43pub_type
杂志文章abstract:BACKGROUND:Elevated plasma total homocysteine (tHcy) is associated with a higher risk of thrombosis. Crohn's disease (CD) is associated with hypercoagulability of undefined etiology. We investigated tHcy in patients with CD and its relationship with vitamin status, disease activity, location, duration, and history of t...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-200108000-00008
更新日期:2001-08-01 00:00:00
abstract:GOALS:The aim of this study was to determine the effect ofoctreotide on active or recent gastrointestinal bleeding from benign peptic ulcers. STUDY:This is a prospective, randomized study including 110 patients with gastric or duodenal peptic ulcers presenting with active spurting or oozing bleeding or nonbleeding vis...
journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004836-200403000-00009
更新日期:2004-03-01 00:00:00
abstract::Infliximab is efficacious for refractory Crohn's disease, but delayed hypersensitivity reactions preclude retreatment for patients experiencing this complication. We report the results of four patients offered enrollment in an open label trial of thalidomide as "salvage" therapy for their refractory disease. Two patie...
journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1097/00004836-200208000-00006
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abstract:GOAL:To prospectively assess the utility of multidetector row computed tomography angiography (MDCTA) in the diagnosis of active gastrointestinal bleeding (GIB). BACKGROUND:MDCTA is a relatively recent advance in CT scanning technology enabling excellent vascular visualization and detection of various vascular abnorma...
journal_title:Journal of clinical gastroenterology
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doi:10.1097/MCG.0b013e31823337ee
更新日期:2012-01-01 00:00:00
abstract::We undertook a prospective study of the effect of incidental appendectomy on the safety of cholecystectomy in patients under the age of 50 years. One hundred twenty patients were randomized to have either cholecystectomy alone or cholecystectomy and appendectomy. All patients received preoperative antibiotic cover. Bo...
journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-08-01 00:00:00
abstract::The fear of cancer has evoked calls for intensive surveillance programs in Barrett's esophagus. Two evolving issues are fueling this fire: (a) the rising risk of adenocarcinoma of the esophagus over the past 20 years and (b) the coincidental increase in the recognized prevalence of Barrett's esophagus in the general p...
journal_title:Journal of clinical gastroenterology
pub_type: 社论
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199206001-00025
更新日期:1992-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Hepatitis C virus (HCV) infection is prevalent in Latinos. There is some evidence that progression to cirrhosis is more rapid. END POINTS:To calculate time of cirrhosis from time of HCV infection in a large Latino population. Other end points were to assess variables that predict cirrhosis and the effect of...
journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199906000-00009
更新日期:1999-06-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-200004000-00017
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Laparoscopic Heller myotomy (HM) has become an increasingly preferred modality to treat achalasia. However, the treatment course after a failed myotomy is controversial with fears that pneumatic dilation (PD) has high perforation risk. GOAL:To compare success and safety of graded PD with Rigiflex balloons i...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-200411000-00004
更新日期:2004-11-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-200210000-00013
更新日期:2002-10-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00