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Systematic antigenic profiling of hematopoietic antigens on ovarian carcinoma cells identifies membrane proteins for targeted therapy development.

Abstract：

OBJECTIVE:We studied ovarian cancers for the expression of membrane markers of hematopoietic origin. STUDY DESIGN:We used flow cytometry to systematically characterize the expression of more than 30 hematologic antigens on ovarian carcinoma cell lines and to assess their stability under estrogen exposure. The expression of the antigens was validated by a bioinformatics survey and immunohistochemical staining of ovarian cancer specimens. RESULTS:Several antigens were expressed by the majority of the cells, such as CD15, CD71, and CD138, whereas others were found on small and distinct cellular subpopulations. The expression patterns of the different markers were unaffected by estrogen exposure, indicating their stability. CONCLUSION:The antigens described in our work may serve as potential targets for new and existing targeted drugs.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Helpman L,Katz BZ,Safra T,Schreiber L,Levine Z,Nemzer S,Kinar Y,Grisaru D

doi

10.1016/j.ajog.2009.05.013

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

196.e1-7

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)00507-9

journal_volume

201

pub_type

杂志文章

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