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On the regulation of fetal and maternal 16 alpha- hydroxydehydroepiandrosterone and its sulfate by cortisol and ACTH in human pregnancy at term.

Abstract：

:In studying the mechanisms which govern estriol production in human pregnancy at term, 16 alpha OH-DHEA, 16alpha-OH-DHEA sulfate, and unbound unconjugated cortisol were measured in peripheral venous plasma of 28 healthy women and in cord venous and arterial plasms of their newborn infants at the time of elective cesarean section prior to the onset of labor. In eight cases treated with 150 mg. of cortisol, maternal and cord plasma 16alpha-OH-DHEA and its sulfate were considerably lower than in 10 control cases. Approximately 4 to 8 1/2 hours after injection of 40 I.U. of Depot-ACTH, both of these estriol precursors were also significantly decreased. It is concluded from these experiments that cortisol causes a decrease of estriol mainly by suppressing fetal 16alpha-OH-DS.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Simmer HH,Frankland M,Greipel M

doi

10.1016/0002-9378(75)90468-8

subject

Has Abstract

pub_date

1975-03-01 00:00:00

pages

646-52

issue

5

eissn

0002-9378

issn

1097-6868

pii

0002-9378(75)90468-8

journal_volume

121

pub_type

杂志文章

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