Cerebral hemorrhage associated with sildenafil (Revatio) in an infant.

Abstract:

:A case of cerebral hemorrhage associated with sildenafil (Revatio) use in an infant is presented. Sildenafil is increasingly used in the treatment of primary and secondary pulmonary arterial hypertension and pulmonary arteriovenous fistula. In the reported case, sildenafil used to treat pulmonary arteriovenous fistula improved right-to-left shunting across the pulmonary fistula but resulted in cerebral hemorrhage. Cerebral hemorrhage, a previously reported complication of sildenafil, developed in an infant after a rapid increase in dose, to 4.7 mg/kg/day. Therefore, sildenafil doses must be increased only with care, and cerebral hemorrhage must be considered a potential complication.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Samada K,Shiraishi H,Aoyagi J,Momoi MY

doi

10.1007/s00246-009-9460-z

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

998-9

issue

7

eissn

0172-0643

issn

1432-1971

journal_volume

30

pub_type

杂志文章
  • Tissue Doppler echocardiography before and after the surgical reconstruction of an insufficient mitral valve in a patient with Fontan circulation.

    abstract::We report a patient with tricuspid atresia after total cavopulmonary connection who developed significant mitral valve regurgitation. Doppler myocardial echocardiography tracings showed "pseudonormalization" of diastolic velocities. After successful surgical reconstruction of the mitral valve, the diastolic myocardial...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-006-1283-6

    authors: Petzuch K,Eicken A,Marek J,Vogel M,Schreiber C,Hess J

    更新日期:2006-07-01 00:00:00

  • Trends in Infant Mortality After TAPVR Repair over 18 Years in Texas and Impact of Hospital Surgical Volume.

    abstract::For some congenital heart lesions, higher institutional surgical volume has been associated with better survival than in lower volume centers. The relationship between institutional surgical volume and mortality in infants after total anomalous pulmonary vein return (TAPVR) repair has not been well explored. The Texas...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-019-02224-x

    authors: Lahiri S,Wang Y,Caldarone CA,Morris SA

    更新日期:2020-01-01 00:00:00

  • Vitamin D, Low-Grade Inflammation and Cardiovascular Risk in Young Children: A Pilot Study.

    abstract::Vitamin D has anti-inflammatory properties, and deficiency is prevalent in children. There is a paucity of data regarding vitamin D status and its correlation with low-grade inflammation and vasculature. We prospectively enrolled 25 children, 9-11 years old (13 male); 21 obese. Eight atherosclerosis-promoting risk fac...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-015-1162-0

    authors: Singh J,Merrill ED,Sandesara PB,Schoeneberg L,Dai H,Raghuveer G

    更新日期:2015-10-01 00:00:00

  • Complex congenital cardiovascular anomalies evaluated by continuous-rotation computed tomography in children.

    abstract::The slip ring and nutate/rotate configuration of the new, fourth-generation, computed tomography (CT) (TCT-900S, Toshiba Medical Company) makes it possible to scan consecutively 25 slices every 75 s. This scanner also rapidly provides hemodynamic and multiplanar reconstruction images. Studies were performed on 13 chil...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02309917

    authors: Yamada T,Harada J,Tada S

    更新日期:1989-04-01 00:00:00

  • Patent foramen ovale and left atrial appendage: new devices and methods for closure.

    abstract::Transcatheter closure of atrial septal defects (ASDs) has become a routine procedure in many countries of the world. It spares many patients cardiac surgery and has proven efficacy in long-term studies. Device improvements have resulted in a continuous reduction of complications and of residual shunt frequency. ASD cl...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-005-1011-7

    authors: Hein R,Bayard Y,Taaffe M,Büscheck F,Ostermayer S,Billinger K,Reschke M,Trepels T,Lissmann-Jensen H,Lang K,Römer A,Wilson N,Sievert H

    更新日期:2005-05-01 00:00:00

  • Validation of cardiac output measurement by ultrasound dilution technique with pulmonary artery thermodilution in a pediatric animal model.

    abstract::Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (C...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-011-9915-x

    authors: Darling E,Thuramalla N,Searles B

    更新日期:2011-06-01 00:00:00

  • Double-outlet single ventricle and an abdominal vascular mass: in utero diagnosis with pathological confirmation.

    abstract::A fetal echocardiographic scan was performed when routine prenatal ultrasound screening failed to identify four cardiac chambers. The scan showed a single ventricle with an associated circoid varicosity. Because of these anomalies, amniocentesis was suggested and trisomy 18 confirmed. The presence of major cardiac str...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00794843

    authors: Duncan WJ,George D,Ezzat W,Wallace K,Van den Beuken B

    更新日期:1993-01-01 00:00:00

  • Unusual ultrasound finding of patent ductus arteriosus in a preterm infant.

    abstract::Patency of the ductus arteriosus (PDA) is a common finding in small premature infants. Recently pulsed-Doppler-cross sectional echocardiography (PD-CSE) has been successfully used in these patients. We report a case of a premature infant with an unusual PD-CSE pattern. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02279882

    authors: Marasini M,Pongiglione G,Silvestri G,Ribaldone D,Garello-Cantoni L

    更新日期:1988-01-01 00:00:00

  • Persistent truncus arteriosus with double aortic arch and mitral stenosis.

    abstract::This report describes a case involving the rare combination of persistent truncus arteriosus type A2, double aortic arch, and mitral stenosis. At the age of 26 days, the patient underwent division of the right-sided aortic arch with tracheal compression and bilateral pulmonary banding. Fontan completion was successful...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0572-5

    authors: Imai K,Tsukuda K,Sakazaki H,Fujiwara K

    更新日期:2013-01-01 00:00:00

  • An Alternative Strategy for Bridge-to-Transplant/Recovery in Small Children with Dilated Cardiomyopathy.

    abstract::Dilated cardiomyopathy in children still has a poor prognosis with high rates of mortality and cardiac transplantation (resp. around 20 and 25%). Awaiting transplantation or possible recovery, these pediatric patients are mechanically supported with extracorporeal membrane oxygenation or a paracorporeal ventricular as...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-017-1610-0

    authors: Mets G,Panzer J,De Wolf D,Bové T

    更新日期:2017-06-01 00:00:00

  • Successful management of isolated ventricular inversion in an adult.

    abstract::We report a case of isolated ventricular inversion in a 42-year-old woman. This rare congenital cardiac anomaly was corrected by an intraatrial baffle procedure. She also underwent left-sided double-chamber endocardial pacemaker implantation for postoperative tachycardia bradycardia syndrome. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0583-3

    authors: Kannan BR,Kamath KP,Rao SG,Kumar RK

    更新日期:2004-09-01 00:00:00

  • Isolated congenital left ventricular diverticulum.

    abstract::Congenital diverticulum of the left ventricle, a rare malformation, is usually associated with midline thoracoabdominal defect. We describe a case with congenital left ventricular diverticulum presenting as an isolated lesion. The lesion was suspected on two-dimensional echocardiography and was confirmed by cardiac ca...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02524804

    authors: Wu JM,Yu CY

    更新日期:1996-07-01 00:00:00

  • CCN1 mutation is associated with atrial septal defect.

    abstract::The genetic basis of congenital heart disease remains unknown in most of the cases. Recently, a novel mouse model shed new light on the role of CCN1/CYR61, a matricellular regulatory factor, in cardiac morphogenesis. In a candidate gene approach, we analyzed a cohort of 143 patients with atrial septal defects (ASD) by...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-014-1001-8

    authors: Perrot A,Schmitt KR,Roth EM,Stiller B,Posch MG,Browne EN,Timmann C,Horstmann RD,Berger F,Özcelik C

    更新日期:2015-02-01 00:00:00

  • Feasibility and Efficacy of Defatted Human Milk in the Treatment for Chylothorax After Cardiac Surgery in Infants.

    abstract::Chylothorax is a well-described complication after cardiothoracic surgery in children. Medical nutritional therapy for chylothorax includes medium-chain triglyceride (MCT) formulas and reduction in enteral long-chain triglyceride intake to reduce chyle production. Human milk is usually eliminated from the diet of infa...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-016-1393-8

    authors: Fogg KL,DellaValle DM,Buckley JR,Graham EM,Zyblewski SC

    更新日期:2016-08-01 00:00:00

  • Contribution of long-QT syndrome genetic variants in sudden infant death syndrome.

    abstract::A cohort of 52 French unrelated infant cases who died unexpectedly before they reached 12 months of age was blindly investigated to better quantify the contribution of long-QT syndrome (LQTS) genetic variants in French cases of sudden infant death syndrome (SIDS). After a standardized autopsy protocol, a blinded molec...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-009-9417-2

    authors: Millat G,Kugener B,Chevalier P,Chahine M,Huang H,Malicier D,Rodriguez-Lafrasse C,Rousson R

    更新日期:2009-05-01 00:00:00

  • Cost-effectiveness analysis of stents, balloon angioplasty, and surgery for the treatment of branch pulmonary artery stenosis.

    abstract::Branch pulmonary artery stenosis is a common problem in pediatric cardiology. Treatment has included surgery, balloon angioplasty, and balloon expandable stent placement. It was the purpose of this investigation to demonstrate the cost-effectiveness of each of these modes of treatment. From 1983 to 1994 there were 30 ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002469900195

    authors: Trant CA Jr,O'Laughlin MP,Ungerleider RM,Garson A Jr

    更新日期:1997-09-01 00:00:00

  • Age-Dependent Association Between Pre-transplant Blood Transfusion and Outcomes of Pediatric Heart Transplantation.

    abstract::Avoidance of red blood cell (RBC) transfusions in patients awaiting heart transplantation (HTx) has been suggested to minimize the risk of allosensitization. Although recent studies have suggested that an immature immune system in younger HTx recipients may reduce risks associated with RBC transfusion, the role of age...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-1814-y

    authors: McKee C,Tumin D,Alevriadou BR,Nicol KK,Yates AR,Hayes D Jr,Tobias JD

    更新日期:2018-04-01 00:00:00

  • Pulmonary hypertension in Kawasaki disease.

    abstract::This report describes the case of two pediatric patients who demonstrated echocardiographic evidence of pulmonary hypertension (PH) during the acute phase of Kawasaki disease. The etiology of PH development in this setting is currently unknown, but the authors hypothesize that pulmonary vasculitis may play a significa...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-012-0510-6

    authors: Nicholson GT,Samai C,Kanaan U

    更新日期:2013-01-01 00:00:00

  • Respiratory Testing and Hospital Outcomes in Asymptomatic Infants Undergoing Heart Surgery.

    abstract::Respiratory viral infections in infants undergoing congenital heart surgery lead to prolonged intubation time, hospital (HLOS) and cardiac intensive care unit length of stay (CICU LOS). The objective of this study was to evaluate the prevalence of respiratory viruses using molecular testing in otherwise healthy infant...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-1994-5

    authors: Delgado-Corcoran C,Blaschke AJ,Ou Z,Presson AP,Burch PT,Pribble CG,Menon SC

    更新日期:2019-02-01 00:00:00

  • Immediate Postnatal Ventricular Performance Is Associated with Mortality in Hypoplastic Left Heart Syndrome.

    abstract::Right ventricular (RV) function as assessed by deformation has been evaluated prenatally and after palliation in hypoplastic left heart syndrome (HLHS). However, limited data exist about the immediate postnatal cardiac adaptation and RV function in HLHS. We compared echocardiographic measures of cardiac performance in...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-1974-9

    authors: Altit G,Bhombal S,Chock VY,Tacy TA

    更新日期:2019-01-01 00:00:00

  • Predictors of Prolonged Hospital Length of Stay Following Stage II Palliation of Hypoplastic Left Heart Syndrome (and Variants): Analysis of the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) Database.

    abstract::The objective of this study is to identify predictors of prolonged hospital length of stay (LOS) for single ventricle patients following stage 2 palliation (S2P), excluding patients who underwent a hybrid procedure. We explore the impact of demographic features, stage 1 palliation (S1P), interstage I (IS1) management,...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-015-1208-3

    authors: Baker-Smith CM,Goldberg SW,Rosenthal GL

    更新日期:2015-12-01 00:00:00

  • Echocardiographic predictors of early postsurgical myocardial dysfunction in pediatric patients with aortic valve insufficiency.

    abstract::In chronic aortic insufficiency (AI), left-ventricular (LV) dysfunction must be detected early to allow timely surgery. Strain and strain rate have been used for this purpose in adults, but the value of this method in pediatric AI has not been established. Forty patients with moderate to severe AI were included in thi...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0646-z

    authors: Lowenthal A,Tacy TA,Behzadian F,Punn R

    更新日期:2013-08-01 00:00:00

  • 1173C>T polymorphism in VKORC1 modulates the required warfarin dose.

    abstract::The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-005-1150-x

    authors: Kosaki K,Yamaghishi C,Sato R,Semejima H,Fuijita H,Tamura K,Maeyama K,Yamagishi H,Sugaya A,Dodo H,Tanigawara Y,Takahashi T

    更新日期:2006-11-01 00:00:00

  • Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D): Review of 16 Pediatric Cases and a Proposal of Modified Pediatric Criteria.

    abstract::Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a heritable cardiomyopathy characterized by fibro-fatty replacement of right ventricular myocardium. Diagnostic criteria, established in 1994 and modified in 2010, are based on predominately adult manifestations of ARVC/D. The goal of this paper is ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-015-1327-x

    authors: Deshpande SR,Herman HK,Quigley PC,Shinnick JK,Cundiff CA,Caltharp S,Shehata BM

    更新日期:2016-04-01 00:00:00

  • Incidence of femoral vein occlusion after catheter ablation in children: evaluation with magnetic resonance angiography.

    abstract::Catheter ablation in children requires placement of multiple large femoral venous sheaths and catheters. Magnetic resonance angiography (MRA) was used to evaluate the effect of indwelling lines on femoral venous blood flow. Between October 1993 and February 1994 a total of 17 patients scheduled for catheter ablation u...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002469900151

    authors: Miga DE,McKellar LF,Denslow S,Wiles HB,Case CL,Gillette PC

    更新日期:1997-05-01 00:00:00

  • Crossed pulmonary arteries: a report on 20 cases with an emphasis on the clinical features and the genetic and cardiac abnormalities.

    abstract::Crossed pulmonary arteries (CPAs) are a rare abnormality in which the ostium of the left pulmonary artery originates superior to the right pulmonary artery and to its right. Recognition of this rare pathology is important because it generally is accompanied by other congenital heart defects, extracardiac anomalies, an...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0714-4

    authors: Babaoğlu K,Altun G,Binnetoğlu K,Dönmez M,Kayabey Ö,Anık Y

    更新日期:2013-01-01 00:00:00

  • The wandering pacemaker: intraperitoneal migration of an epicardially placed pacemaker and femoral nerve stimulation.

    abstract::A premature child with congenital complete heart block had an epicardial single-chamber pacemaker implanted at 2 days of age. At 21 months of age, while sitting or standing, the patient's right anterior thigh muscles contracted at her pulse rate. Surgical exploration revealed a free-floating pacemaker in her peritoneu...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002469900430

    authors: Salim MA,DiSessa TG,Watson DC

    更新日期:1999-03-01 00:00:00

  • Development of a charge adjustment model for cardiac catheterization.

    abstract::A methodology that would allow for comparison of charges across institutions has not been developed for catheterization in congenital heart disease. A single institution catheterization database with prospectively collected case characteristics was linked to hospital charges related and limited to an episode of care i...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-014-0994-3

    authors: Brennan A,Gauvreau K,Connor J,O'Connell C,David S,Almodovar M,DiNardo J,Banka P,Mayer JE Jr,Marshall AC,Bergersen L

    更新日期:2015-02-01 00:00:00

  • Successful emergent coronary thrombolysis in a neonate with Kawasaki's disease.

    abstract::This report describes the case of a 29-day-old infant with Kawasaki's disease who presented in extremis with multiple coronary aneurysms and coronary thromboses, myocardial ischemia, and congestive heart failure. The infant successfully underwent emergent coronary thrombolysis with tissue plasminogen activator. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-010-9781-y

    authors: Karia VR,Hescock GC,Gedalia A,Ross-Ascuitto N

    更新日期:2010-11-01 00:00:00

  • Anomalous origin of the left coronary artery from the pulmonary artery in a premature infant with preserved left ventricular function.

    abstract::Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare condition. The majority of cases present with impaired left ventricular function. We report on a premature infant who was diagnosed at a gestational age near term with ALCAPA during routine cardiac examination. The patient showed...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-004-0878-z

    authors: Grosse-Wortmann L,Wenzl T,Hoevels-Guerich HH

    更新日期:2006-03-01 00:00:00