Abstract:
:A case of cerebral hemorrhage associated with sildenafil (Revatio) use in an infant is presented. Sildenafil is increasingly used in the treatment of primary and secondary pulmonary arterial hypertension and pulmonary arteriovenous fistula. In the reported case, sildenafil used to treat pulmonary arteriovenous fistula improved right-to-left shunting across the pulmonary fistula but resulted in cerebral hemorrhage. Cerebral hemorrhage, a previously reported complication of sildenafil, developed in an infant after a rapid increase in dose, to 4.7 mg/kg/day. Therefore, sildenafil doses must be increased only with care, and cerebral hemorrhage must be considered a potential complication.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Samada K,Shiraishi H,Aoyagi J,Momoi MYdoi
10.1007/s00246-009-9460-zsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
998-9issue
7eissn
0172-0643issn
1432-1971journal_volume
30pub_type
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journal_title:Pediatric cardiology
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