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The metabolomics of carotenoids in engineered cell factory.

Abstract：

:Carotenoids such as beta-carotene, lycopene, and antheraxanthin have plenty of scientific and commercial value. The comprehensive investigation of carotenoids drives people to improve and develop all kinds of analytical techniques to approach or even achieve "versatile" analysis. The metabolic engineering efforts in plants and algae have progressed rapidly, aiming to enable the use of plants and algae as "cell factories" for producing specific or novel carotenoids, such as beta-carotene (provitamin A) in Gold rice, while the emerging technologies of metabolomics support it by providing comprehensive analysis of carotenoids biochemical characterizations. This review describes metabolomics as a high-throughput platform to study carotenoids, including the engineering methods in the plants or algae, the bioinformatics for metabolomics, and the metabolomics of carotenoids in engineered cell factory. Modern systems biology tools, together with the development of genomics and metabolomics databases, will dramatically facilitate the advancement of our knowledge in gene-to-metabolite networks in plants. Metabolomics accompanying genomics, transcriptomics, and proteomics as well as bioinformatics facilitate metabolic engineering efforts towards designing superior biocatalysts in cell factories. Ongoing advances in biological techniques coupled with crucial metabolic networks will further promote plants and algae as attractive platforms for the production of numerous high-value compounds such as carotenoids.

journal_name

Appl Microbiol Biotechnol

journal_title

Applied microbiology and biotechnology

authors

Liu GN,Zhu YH,Jiang JG

doi

10.1007/s00253-009-2069-6

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

989-99

issue

6

eissn

0175-7598

issn

1432-0614

journal_volume

83

pub_type

杂志文章,评审

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