Abstract：
:Recent studies suggest that no distinct glycemic threshold consistently differentiates individuals with or without retinopathy. The authors sought to determine whether the same was true for other microvascular complications. They studied 5,094 participants with fasting plasma glucose values and concurrent microvascular complications from 4 previous cross-sectional surveys carried out in Singapore (1982-1998) who attended a follow-up examination in 2004-2007. Peripheral neuropathy was diagnosed based on abnormal responses to a 10-g monofilament or neurothesiometer test. Chronic kidney disease was defined in various ways by using albuminuria (urine albumin:creatinine ratio >30 microg/mg) and estimated glomerular filtration rate, alone and in combination. Prevalence of peripheral neuropathy was 7.5%. For chronic kidney disease, prevalence of albuminuria only was 10.5%, estimated glomerular filtration rate of <60 mL/minute per 1.73 m(2) only was 4.1%, and both was 2.1%. Prevalence of peripheral neuropathy and chronic kidney disease gradually increased in relation to fasting plasma glucose, beginning at levels below the existing diagnostic threshold for diabetes mellitus of 7.0 mmol/L (126 mg/dL). For chronic kidney disease, these associations persisted after adjustment for age, gender, ethnic group, and hypertension. Current diagnostic thresholds for diabetes mellitus have limited sensitivity for identifying individuals with these microvascular complications. Ascertaining these individuals may require development and application of novel screening strategies.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Nang EE,Khoo CM,Tai ES,Lim SC,Tavintharan S,Wong TY,Heng D,Lee Jdoi
10.1093/aje/kwp076subject
Has Abstractpub_date
2009-06-15 00:00:00pages
1454-62issue
12eissn
0002-9262issn
1476-6256pii
kwp076journal_volume
169pub_type
杂志文章abstract：:Four random samples representing populations at low (volunteer blood donors), intermediate, (VD clinic patients), high (family contacts of chronic antigen carriers) and very high (male homosexuals) risk of exposure to HBV were surveyed. Among HBsAg and anti-HBs negative individuals an average of 3.3% were found to be ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1979-07-01 00:00:00
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更新日期：2001-09-01 00:00:00
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更新日期：2013-04-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1975-06-01 00:00:00
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pub_type： 历史文章,杂志文章
doi：10.1093/oxfordjournals.aje.a009215
更新日期：1997-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112783
更新日期：1979-07-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1993-01-15 00:00:00
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更新日期：1994-10-01 00:00:00
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更新日期：2009-04-15 00:00:00
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pub_type： 杂志文章,meta分析
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