Valve repair in rheumatic mitral disease.

abstract：BACKGROUND:Nontranscriptional signaling through estrogen receptors (ERs) is important in the cardiovascular system. In particular, estrogen stimulates endothelial NO synthase (eNOS) via the phosphatidylinositol 3-kinase (PI3K) pathway. The selective estrogen receptor modulator (SERM) raloxifene is effective for the tre...

journal_title：Circulation

authors： Simoncini T,Genazzani AR,Liao JK

更新日期：2002-03-19 00:00:00

abstract：:An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, a...

journal_title：Circulation

authors： Hodgson JM,Marshall JJ

更新日期：1989-05-01 00:00:00

abstract：:The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine ...

journal_title：Circulation

authors： Bridges ND,Farrell PE Jr,Pigott JD 3rd,Norwood WI,Chin AJ

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The beneficial effect of low-dose aspirin in the prevention of coronary vasospasm is well documented. In this study, we investigated the contractile effect of human washed platelets on the human isolated coronary artery. We concentrated on the effect of low-dose aspirin (40 mg/d) taken by the platelet donor ...

journal_title：Circulation

authors： Bax WA,Renzenbrink GJ,van der Linden EA,Zijlstra FJ,van Heuven-Nolsen D,Fekkes D,Bos E,Saxena PR

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction i...

journal_title：Circulation

authors： Wang CY,Wen MS,Wang HW,Hsieh IC,Li Y,Liu PY,Lin FC,Liao JK

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Aprotinin was a commonly used pharmacological agent for homeostasis in cardiac surgery but was discontinued, resulting in the extensive use of lysine analogues. This study tested the hypothesis that early postoperative adverse events and blood product utilization would affected in this post-aprotinin era. M...

journal_title：Circulation

authors： DeSantis SM,Toole JM,Kratz JM,Uber WE,Wheat MJ,Stroud MR,Ikonomidis JS,Spinale FG

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:The strategy for treating patients with severe asymptomatic carotid artery stenosis and cardiac disease remains unresolved. Staged or combined carotid endarterectomy in these patients offers the potential benefit of decreased neurological morbidity during and after cardiac surgery; however, in high-risk pati...

journal_title：Circulation

authors： Van der Heyden J,Suttorp MJ,Bal ET,Ernst JM,Ackerstaff RG,Schaap J,Kelder JC,Schepens M,Plokker HW

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA...

journal_title：Circulation

authors： Da Costa A,Thévenin J,Roche F,Romeyer-Bouchard C,Abdellaoui L,Messier M,Denis L,Faure E,Gonthier R,Kruszynski G,Pages JM,Bonijoly S,Lamaison D,Defaye P,Barthélemy JC,Gouttard T,Isaaz K,Loire-Ardèche-Drôme-Isère-Puy-de-D

更新日期：2006-10-17 00:00:00

abstract：:Periodic fluctuations in the R-R interval have been used as noninvasive measures of cardiac autonomic tone. For example, a reduced heart rate variability has been shown to correlate with an increased mortality in patients recovering from myocardial infarction. The effects that physiologic perturbations such as exercis...

journal_title：Circulation

authors： Billman GE,Hoskins RS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Disease-associated electrophysiological alterations may contribute to the increased predisposition to arrhythmias of the hypertrophied or failing myocardium. An I(f)-like current is expressed in rat left ventricular myocytes (LVMs), its amplitude being linearly related to the severity of cardiac hypertrophy....

journal_title：Circulation

authors： Cerbai E,Pino R,Porciatti F,Sani G,Toscano M,Maccherini M,Giunti G,Mugelli A

更新日期：1997-02-04 00:00:00

abstract：BACKGROUND:In the last decades, interest has increased in the potential deleterious atherogenic effects of some cellular elastase activities. The results of experimental and clinical investigations were inconsistent. In this report, we assessed the associations of serum elastase activity and serum elastase inhibitors w...

journal_title：Circulation

authors： Zureik M,Robert L,Courbon D,Touboul PJ,Bizbiz L,Ducimetière P

更新日期：2002-06-04 00:00:00

abstract：:Although the postoperative hemodynamic and echocardiographic features of idiopathic hypertrophic subaortic stenosis have been studied, the expected consistent postoperative thinning of the interventricular septum has not been reported. In this study, the short-term effects of septal myectomy were evaluated in 16 patie...

journal_title：Circulation

authors： Schapira JN,Stemple DR,Martin RP,Rakowski H,Stinson EB,Popp RL

更新日期：1978-11-01 00:00:00

abstract：:To assess the effects of moderate potassium cardioplegia (37 mEq/l KCl) on the severity of myocardial ischemia during arrest and on post arrest ventricular function, 32 isolated, isovolumic feline hearts were studied before, during and 1 hour after ischemic arrest. Normothermia (37 degrees C) was maintained in the rem...

journal_title：Circulation

authors： Schaff HV,Dombroff R,Flaherty JT,Bulkley BH,Hutchins GM,Goldman RA,Gott VL

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:In heart failure (HF), aldosterone has been implicated in the formation of reactive interstitial fibrosis, a maladaptation that contributes to left ventricular (LV) remodeling. Eplerenone is a novel selective aldosterone blocker. The present study examined the effects of long-term monotherapy with eplerenone...

journal_title：Circulation

authors： Suzuki G,Morita H,Mishima T,Sharov VG,Todor A,Tanhehco EJ,Rudolph AE,McMahon EG,Goldstein S,Sabbah HN

更新日期：2002-12-03 00:00:00

abstract：BACKGROUND:Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while...

journal_title：Circulation

authors： Kroemer HK,Fromm MF,Bühl K,Terefe H,Blaschke G,Eichelbaum M

更新日期：1994-05-01 00:00:00

abstract：:Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous ...

journal_title：Circulation

authors： Ferlinz J,Easthope JL,Aronow WS

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid IMT was measured in young and middle-aged adults to determine its relationship with risk factors measured (1) in childhood, (2) current...

journal_title：Circulation

authors： Davis PH,Dawson JD,Riley WA,Lauer RM

更新日期：2001-12-04 00:00:00

abstract：:Direct examination of the aortic orifice at the level of the aortic valves (aortic valvular orifice area, AVOA) in the short-axis plane was performed with a 3 MHz two-dimensional pulsed Doppler echocardiographic apparatus. The AVOA was mapped with the Doppler gate to detect or rule out the presence of a regurgitant ao...

journal_title：Circulation

authors： Veyrat C,Lessana A,Abitbol G,Ameur A,Benaim R,Kalmanson D

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of cardiovascular d...

journal_title：Circulation

authors： Schjerning Olsen AM,Fosbøl EL,Lindhardsen J,Folke F,Charlot M,Selmer C,Lamberts M,Bjerring Olesen J,Køber L,Hansen PR,Torp-Pedersen C,Gislason GH

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Endocardial mapping of sustained arrhythmias has traditionally been performed with a roving diagnostic catheter. Although this approach is adequate for many tachyarrhythmias, it has limitations. The purpose of this study was to evaluate a novel noncontact mapping system for assessing atrial tachyarrhythmias....

journal_title：Circulation

authors： Kadish A,Hauck J,Pederson B,Beatty G,Gornick C

更新日期：1999-04-13 00:00:00

abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

journal_title：Circulation

authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

更新日期：2017-02-14 00:00:00

abstract：:In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,00...

journal_title：Circulation

authors： Kusama Y,Bernier M,Hearse DJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counterregulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a member of the TGFβ family ...

journal_title：Circulation

authors： Morine KJ,Qiao X,York S,Natov PS,Paruchuri V,Zhang Y,Aronovitz MJ,Karas RH,Kapur NK

更新日期：2018-07-31 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of severe a...

journal_title：Circulation

authors： Liu PP,Blet A,Smyth D,Li H

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their ...

journal_title：Circulation

authors： Suzuki K,Smolenski RT,Jayakumar J,Murtuza B,Brand NJ,Yacoub MH

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:The hypoxia-inducible transcription factor (HIF) subunits are destabilized via the O(2)-dependent prolyl hydroxylase domain proteins (PHD1, PHD2, and PHD3). We investigated whether inhibition of PHDs via upregulating HIF might promote postischemic neovascularization. METHODS AND RESULTS:Mice with right femo...

journal_title：Circulation

authors： Loinard C,Ginouvès A,Vilar J,Cochain C,Zouggari Y,Recalde A,Duriez M,Lévy BI,Pouysségur J,Berra E,Silvestre JS

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the i...

journal_title：Circulation

authors： Pappone C,Manguso F,Vicedomini G,Gugliotta F,Santinelli O,Ferro A,Gulletta S,Sala S,Sora N,Paglino G,Augello G,Agricola E,Zangrillo A,Alfieri O,Santinelli V

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

journal_title：Circulation

authors： Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known. METHODS:We linked adults ≥65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgic...

journal_title：Circulation

authors： Strom JB,Faridi KF,Butala NM,Zhao Y,Tamez H,Valsdottir LR,Brennan JM,Shen C,Popma JJ,Kazi DS,Yeh RW

更新日期：2020-07-21 00:00:00

abstract：:A case history of a 46-year-old Negro male was presented with rheumatic aortic insufficiency, angina pectoris, and possible subacute bacterial endocarditis. While hospitalized, the patient developed angina pectoris associated with micturition. This was not accompanied by a change in blood pressure, pulse, or increase ...

journal_title：Circulation

authors： Morris JJ,McIntosh HD

更新日期：1963-01-01 00:00:00