Abstract:
:Several publications suggest a potential association between the administration of Gadolinium-based contrast agents (GBCAs) and the onset of a rare but serious disease, Nephrogenic Systemic Fibrosis (NSF). The aim of this study was to determine the elimination time-course of Gadolinium (Gd) from skin tissue after application of GBCAs in rats. Seven different marketed GBCAs were injected on five consecutive days at a dose of 2.5 mmol/kg bodyweight into the tail vein of Han-Wistar rats and the Gd concentrations were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in skin biopsies taken at various time-points up to a year after the last injection. Most of the administered Gd was eliminated from the skin within a time-period of about 2 months. However, the repeated administration of linear GBCAs resulted in long-term retention of a small portion of the administered Gd in the skin tissue of rats, with substantially higher values observed in animals treated with non-ionic linear agents than in those that received ionic linear GBCAs. Following treatment with macrocyclic GBCAs, Gd values in the skin were in the same range as observed in the controls from day 24 post-injection onwards. In summary, we observed a correlation between the complex stability of GBCAs and the amount of residual Gd in the skin up to a year after application of GBCAs.
journal_name
Eur Radioljournal_title
European radiologyauthors
Pietsch H,Lengsfeld P,Jost G,Frenzel T,Hütter J,Sieber MAdoi
10.1007/s00330-008-1259-4subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1417-24issue
6eissn
0938-7994issn
1432-1084journal_volume
19pub_type
杂志文章abstract::The aim of the study was to document MRI findings in masticator structures in patients with trismus developing after radiotherapy for nasopharyngeal carcinoma (NPC). MRI neck examinations were reviewed in 35 patients with marked trismus, defined as an interincisal gap of 25 mm or less, post-radiotherapy for NPC. Patie...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1445-z
更新日期:2009-11-01 00:00:00
abstract:KEY POINTS:• Identify, assure, and measure major sources of variability affecting the MRI-directed biopsy pathway for prostate cancer diagnosis.• Develop strategies to control and minimize variations that impair pathway effectiveness including the performance of main players and team working.• Assure end-to-end quality...
journal_title:European radiology
pub_type: 社论
doi:10.1007/s00330-020-07527-9
更新日期:2020-11-25 00:00:00
abstract:OBJECTIVES:To assess the treatment-induced changes of health-related quality-of-life (HRQoL) in patients with venous malformations (VM) who underwent ethanol gel sclerotherapy. METHODS:The prospective study in children and adults was approved by the local ethics committee. 31 patients (mean age 23.42 years, range 6.6 ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4603-0
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:Acoustic radiation force impulse (ARFI) imaging is an ultrasound-based elastography method that is integrated into a conventional ultrasound machine. A meta-analysis based on original and abstract publications was performed to evaluate the overall performance of ARFI for the diagnosis of liver fibrosis. MET...
journal_title:European radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00330-013-2927-6
更新日期:2013-11-01 00:00:00
abstract::Bronchioloalveolar carcinoma (BAC) is a polymorphic lung cancer the incidence of which is rising. The presence of intratumoral radiolucencies is an important feature of bronchioloalveolar carcinoma. The aim of this study was to present pictorially the spectrum of intratumoral radiolucencies visible in BAC. In 57 BACs ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050627
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to assess the image quality and diagnostic value of MR urography in detecting abnormalities of the urinary collecting system relevant for the preoperative evaluation of living renal donors. Study subjects were selected from the existing intravenous urography (IVU) reports: 18 consecutive ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1438-7
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the frequency of diagnosis of high-risk lesions at MRI-guided vacuum-assisted breast biopsy (MRgVABB) and to determine whether underestimation may be predicted. METHODS:Retrospective review of the medical records of 161 patients who underwent MRgVABB was performed. The underestimation rate was d...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1949-6
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To investigate image quality of triple-rule-out (TRO) computed tomography (CT) using a 320-row-detector CT system with substantially reduced contrast medium volume at 100 kV. METHODS:Forty-six consecutive patients with noncritical, acute chest pain underwent 320-row-detector CT using a two-step TRO protocol...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2088-4
更新日期:2011-07-01 00:00:00
abstract::This pictorial review illustrates the anatomical features of normal intra-articular components of the hip and their common disorders on MR arthrography. On T1-weighted MR arthrograms, the normal contrast-filled joint cavity shows a homogeneous high signal intensity. Normal acetabular labrum appears as a well-delineate...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050009
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship of dual-phase dual-energy CT (DE-CT) and tumour size in the evaluation of the response to anti-EGFR therapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Dual-phase DE-CT was performed in 31 patients with NSCLC before the onset of anti-EGFR (erlotinib)...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4092-6
更新日期:2016-08-01 00:00:00
abstract::The original version of this article, published on 01 August 2018, unfortunately contained two mistakes. ...
journal_title:European radiology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00330-018-5713-7
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:CT angiography (CTA) is essential in acute stroke to detect emergent large vessel occlusions (ELVO) and must be interpreted by radiologists with and without subspecialized training. Additionally, grayscale inversion has been suggested to improve diagnostic accuracy in other radiology applications. This study...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06814-9
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To demonstrate the non-inferiority of synthetic image (SI) mammography versus full-field digital mammography (FFDM) in breast tomosynthesis (DBT) examinations. METHODS:An observational, retrospective, single-centre, multireader blinded study was performed, using 2384 images to directly compare SI and FFDM ba...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-017-4991-9
更新日期:2018-02-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,实务指引
doi:10.1007/s00330-007-0792-x
更新日期:2008-01-01 00:00:00
abstract::CT pneumocolon is a promising new technique in the diagnosis and management of colon pathology. CT pneumocolon can detect (sensitivity >95%) and stage (accuracy 79%) colorectal cancer and is very accurate in the differentiation of malignant from benign colonic pathologies. It has excellent detection rates for polyps >...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300100890
更新日期:2001-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2289-1
更新日期:2004-09-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050796
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To assess whether with recent MR technology current patient preparation literature recommendations for female pelvic MRI are still valid and how they are influencing the position of the female pelvic organs, image quality, and diagnostic confidence. METHODS:This prospective study was performed in two centre...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06869-8
更新日期:2020-10-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,多中心研究
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-018-5840-1
更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00330-005-2665-5
更新日期:2005-06-01 00:00:00
abstract::Hybrid imaging with combined positron emission tomography/computed tomography (PET/CT) plays an important role in the staging and management of a wide variety of solid tumours. However, its use in the evaluation of musculoskeletal malignancy has not yet entered routine clinical practice. Cross-sectional imaging with m...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-010-1862-z
更新日期:2010-12-01 00:00:00
abstract::The potential relative beneficial aspects of upright, weight-bearing (pMRI), dynamic-kinetic (kMRI) spinal imaging over that of recumbent MRI (rMRI) include the revelation of occult spinal disease dependent on true axial loading, the unmasking of kinetic-dependent spinal disease and the ability to scan the patient in ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2666-4
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-019-06432-0
更新日期:2020-02-01 00:00:00
abstract::Renal cell carcinoma in a horseshoe kidney is an unusual entity. To our knowledge, only 123 cases have been published to date. We report the first bilateral case of two clear-cell carcinomas in an asymmetrically fused kidney. Optimum preservation of renal function after radical tumor removal requires accurate preopera...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050615
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic accuracy of split-bolus single-scan computed tomography angiography (CTA) protocol for evaluation of acute mesenteric ischemia and alternate diagnoses. MATERIALS AND METHODS:In this IRB-approved, HIPAA-compliant retrospective study, consecutive patients from 21 October 2016 to 6 Ma...
journal_title:European radiology
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
abstract::The role of diffusion-weighted magnetic resonance imaging (DWI) to differentiate breast lesions in vivo was evaluated. Sixty women (mean age, 53 years) with 81 breast lesions were enrolled. A coronal echo planar imaging (EPI) sequence sensitised to diffusion (b value=1,000 s/mm(2)) was added to standard MR. The mean d...
journal_title:European radiology
pub_type: 临床试验,杂志文章
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abstract::Coronary calcium mass percentiles can be derived from electron beam CT as well as from multidetector-row CT of all manufacturers. Coronary calcium mass may serve as a more individualized substitute for age for cardiac risk stratification. The aim was to investigate the potential impact of CT coronary calcium mass quan...
journal_title:European radiology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
abstract::Almost the entire world, not only China, is currently experiencing the outbreak of a novel coronavirus that causes respiratory disease, severe pneumonia, and even death. The outbreak began in Wuhan, China, in December of 2019 and is currently still ongoing. This novel coronavirus is highly contagious and has resulted ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-020-06827-4
更新日期:2020-09-01 00:00:00