Adrenomedullin improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion injury in insulin-resistant rats.

abstract：:Recent evidence suggests that ANF neurons of the hypothalamus are dopamine sensitive, and the catecholamine may exert a direct stimulatory or inhibitory effect on the neurons mediated through D1 or D2 receptors, respectively, in a manner related to the differential dopamine binding sensitivity of the two receptor subt...

journal_title：Endocrinology

authors： Lee D,Huang W,Copolov DL,Lim AT

更新日期：1995-12-01 00:00:00

abstract：:The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...

journal_title：Endocrinology

authors： Wong EH,Tan CH,Khoo HE,Ng FH,Lim KL,Ciaraldi TP

更新日期：1995-04-01 00:00:00

abstract：:Current in vivo and in vitro data indicate that progesterone (P) is required for epithelial proliferation in mammary glands of adult mice. P receptors (PgR) in adult mammary glands are under estrogenic regulation. By contrast in immature, pubertal 5-week-old mice, PgR are present only in low concentration and cannot b...

journal_title：Endocrinology

authors： Haslam SZ

更新日期：1988-02-01 00:00:00

abstract：:Both serotonin (5-HT) and opiates exert a stimulatory effect on PRL secretion. Some evidence suggests that the action of opiates may be elicited through serotonergic neurons. We tested this hypothesis in the present study by evaluating the effect of perturbation of the serotonergic system on PRL secretion induced by f...

journal_title：Endocrinology

authors： Pan JT,Teo KL

更新日期：1989-10-01 00:00:00

abstract：:Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing o...

journal_title：Endocrinology

authors： Inagaki T,Frankfurt M,Luine V

更新日期：2012-07-01 00:00:00

abstract：:Acute nephrectomy seriously impairs hypovolemic adrenal epinephrine (E) release in the anesthetized dog. That systemically delivered angiotensin II totally restores E release to acutely anephric dogs is equally clear, but the dose-response relationship of this angiotensin II effect is not known. Adrenal secretion rate...

journal_title：Endocrinology

authors： Badder EM,Duarte B,Seaton JF,Hamaji M,Harrison TS

更新日期：1985-11-01 00:00:00

abstract：:Insulin radioreceptor assays were developed using splenic leukocytes and peripheral erythrocytes from individual mice. Splenic leukocytes were prepared using an NH4Cl buffer which did not alter insulin binding, but gave much higher yields than density gradient methods. Mouse erythrocytes were isolated from heparinized...

journal_title：Endocrinology

authors： Shimizu F,Kahn CR

更新日期：1982-02-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is specifically and reversibly bound by particulate fractions from adrenals from fetal calves and lambs. These binding sites appear to be located primarily in the adrenal medulla and have properties very similar to those which we have detected in adult human, bovine, and ovine adrenal medulla. ...

journal_title：Endocrinology

authors： Karaplis AC,Powell WS

更新日期：1981-12-01 00:00:00

abstract：:Previous studies have shown that the adenylyl cyclase of intact granulosa cells from immature porcine follicles has a uniquely prolonged responsiveness to FSH and an atypically poor responsiveness to cholera toxin relative to other cells. The present studies were designed to determine if these characteristics were due...

journal_title：Endocrinology

authors： Hunzicker-Dunn M,LaBarbera AR

更新日期：1986-01-01 00:00:00

abstract：:Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nor-deoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 micrograms/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1% NaCl solution. Compara...

journal_title：Endocrinology

authors： Hall CE,Gomez-Sanchez CE,Holland OB,Nasseth D

更新日期：1979-09-01 00:00:00

abstract：:The inhibitory effect of T3 on TSH release was studied on a population of thyrotroph-enriched cells prepared from bovine pituitary glands by centrifugal elutriation. The cells (2.0 X 10(5)/ml) were cultured for 2 days and then exposed to TRH, phorbol-12 myristate-13 acetate (PMA), or calcium ionophore (A23187) with or...

journal_title：Endocrinology

authors： Yanagisawa M,Mirell CJ,Hershman JM

更新日期：1988-05-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Rusvai E,Fejes-Tóth G

更新日期：1994-04-01 00:00:00

abstract：:Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase up to several thousand-fold in human sepsis, and immunoneutralization improves survival in two animal models of this disease. Herein, we analyzed inflammation-mediated calcitonin I gene (CALC I) expression in human adipocyte ...

journal_title：Endocrinology

authors： Linscheid P,Seboek D,Nylen ES,Langer I,Schlatter M,Becker KL,Keller U,Müller B

更新日期：2003-12-01 00:00:00

abstract：:As the incidence of obesity continues to increase, the development of effective therapies is a high priority. The endocannabinoid system has emerged as an important influence on the regulation of energy homeostasis. The endocannabinoids anandamide and 2-arachidonoylglycerol act on cannabinoid receptor-1 (CB1) in the b...

journal_title：Endocrinology

authors： de Kloet AD,Woods SC

更新日期：2009-06-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00

abstract：:Dexamethasone, a synthetic glucocorticoid, inhibits the initial rate of transport of the nonmetabolizable amino acid, alpha-aminoisobutyric acid, in rat hepatoma tissue culture (HTC) cells. To determine whether this inhibition is mediated by the same proximal steps as is the steroidal induction of tyrosine aminotransf...

journal_title：Endocrinology

authors： Gelehrter TD,McDonald RA

更新日期：1981-08-01 00:00:00

abstract：:We have previously shown that in reaggregate cell cultures of 14-day-old female rat pituitary, LHRH is capable of stimulating lactotrophs to enter the S-phase of the cell cycle, and that this effect is mediated by paracrine growth factors secreted from gonadotrophs. In the present report we describe the isolation, pur...

journal_title：Endocrinology

authors： Tilemans D,Andries M,Proost P,Devreese B,Van Beeumen J,Denef C

更新日期：1994-07-01 00:00:00

abstract：:LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period...

journal_title：Endocrinology

authors： Nava LE,Malacara JM

更新日期：1987-10-01 00:00:00

abstract：:Hypothyroid patients and mice have been shown to have circulating TSH that is more highly sialylated than their euthyroid counterparts. To learn about the underlying cellular mechanisms responsible for this increased sialylation of TSH, we used in situ hybridization to examine the beta-galactoside alpha-2,6-sialyltran...

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-06-01 00:00:00

abstract：:Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...

journal_title：Endocrinology

authors： Adamson AD,Friedrichsen S,Semprini S,Harper CV,Mullins JJ,White MR,Davis JR

更新日期：2008-02-01 00:00:00

abstract：:Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...

journal_title：Endocrinology

authors： Zhang BJ,Kusano K,Zerfas P,Iacangelo A,Young WS 3rd,Gainer H

更新日期：2002-03-01 00:00:00

abstract：:Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....

journal_title：Endocrinology

authors： Sellix MT,Murphy ZC,Menaker M

更新日期：2013-04-01 00:00:00

abstract：:Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is highly expressed in the mouse uterus on days 3 a...

journal_title：Endocrinology

authors： Deng WB,Liang XH,Liu JL,Yang ZM

更新日期：2014-07-01 00:00:00

abstract：:Intestinal calcium and phosphate transport was studied in normal and hypophosphatemic mice fed a variety of dietary regimens with and without vitamin D. Regardless of dietary phosphorus levels, the genetic hypophosphatemic mice had drastically reduced levels of serum inorganic phosphate and intestinal phosphate transp...

journal_title：Endocrinology

authors： O'Doherty PJ,DeLuca HF,Eicher EM

更新日期：1977-10-01 00:00:00

abstract：:The biosynthesis of various hypothalamic neuropeptides has been previously reported in anterior pituitary cells but not in intermediate lobe cells. We have recently demonstrated the occurrence of two somatostatin isoforms in the frog brain, namely somatostatin-14 (SS1) and [Pro(2),Met(13)]somatostatin-14 (SS2). In the...

journal_title：Endocrinology

authors： Tostivint H,Vieau D,Chartrel N,Boutelet I,Galas L,Fournier A,Lihrmann I,Vaudry H

更新日期：2002-09-01 00:00:00

abstract：:Levels of insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins (IGFBPs) were studied in ovine follicular fluid and serum with a view to determining their respective endocrine and/or paracrine roles in ovarian folliculogenesis. Ovarian follicles of Ile-de-France ewes were dissected and measured indivi...

journal_title：Endocrinology

authors： Monget P,Monniaux D,Pisselet C,Durand P

更新日期：1993-04-01 00:00:00

abstract：:Extracts of spinach contain somatostatin (SRIF)-related material (6-80 pg/g wet wt). The SRIF-related material, when purified on HPLC, was recovered as two major mol wt forms; one that eluted with a retention time similar to that of synthetic SRIF-28 and reacted in both N- and C-terminal-specific immunoassays, and a s...

journal_title：Endocrinology

authors： LeRoith D,Pickens W,Wilson GL,Miller B,Berelowitz M,Vinik AI,Collier E,Cleland CF

更新日期：1985-11-01 00:00:00

abstract：:Previous studies have shown that aldosterone plus salt loading cause cardiac hypertrophy in rats in vivo, and that in vitro, both aldosterone and glucose stimulate fibroblast growth. The present studies examined the effects of adrenal steroids via mineralocorticoid and glucocorticoid receptors (MR and GR) on [3H]leuci...

journal_title：Endocrinology

authors： Sato A,Funder JW

更新日期：1996-10-01 00:00:00