Abstract：
STUDY DESIGN:This study was designed to investigate the effects of oxidant and antioxidant treatment, as well as regular exercise, on neurotrophin levels in the spinal cord of rats. OBJECTIVES:Reactive oxygen species (ROS) play a role in neurodegenerative diseases, but ROS at moderate levels could stimulate biochemical processes through redox-sensitive transcription. METHODS:Exercised or sedentary animals were injected subcutaneously with hydrogen peroxide (H(2)O(2)), N-tert butyl-alpha-phenyl nitrone (PBN) or saline for the last 2 weeks of a 10-week experimental period to challenge redox balance. Free radical (FR) concentration was evaluated in the spinal cord by electron spin resonance, protein carbonyls, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) levels and the mRNA expression of BDNF receptor and tyrosine kinase receptor B (TrKB). SETTING:Research Institute of Sport Science, Semmelweis University, Budapest, Hungary. RESULTS:Exercise or PBN decreased the concentration of FR, whereas the carbonyl content did not change. BDNF was significantly decreased in exercised sham and sedentary PBN-treated groups, and its content correlated with the level of FR. GDNF was significantly increased in sedentary H(2)O(2)-treated groups. No differences were observed in TrkB mRNA expression among groups. CONCLUSIONS:Results suggest that regular exercise alone and PBN in sedentary animals can successfully decrease FR levels in the spinal cord. Redox alteration seems to affect the levels of GDNF and BDNF, which might have clinical consequences, as neurotrophins play an important role in cellular resistance and regeneration.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Siamilis S,Jakus J,Nyakas C,Costa A,Mihalik B,Falus A,Radak Zdoi
10.1038/sc.2008.125subject
Has Abstractpub_date
2009-06-01 00:00:00pages
453-7issue
6eissn
1362-4393issn
1476-5624pii
sc2008125journal_volume
47pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract：:An extremely rare case of extradural spinal cysticercosis in an adult male is presented. The patient had evidence of extradural granulation tissue with associated destruction of C4 and C5 pedicles and laminae, causing tetraparesis. Histopathological examination revealed evidence of a degenerated cysticercal cyst with ...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3100524
更新日期：1998-04-01 00:00:00
abstract：STUDY DESIGN:A survey administered to 66 individuals with spinal cord injury (SCI) implementing a choice-based conjoint (CBC) analysis. Six attributes with three levels each were defined and used to generate choice sets with treatment scenarios. Patients were asked to choose the scenario that they preferred most. OBJE...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2010.65
更新日期：2011-01-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional study. OBJECTIVE:To assess the influence of various surfaces on the gait characteristics of ambulatory participants with incomplete spinal cord injury (SCI) as compared to data from able-bodied participants. SETTING:A tertiary rehabilitation center and communities. METHODS:Seventy part...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0282-4
更新日期：2019-09-01 00:00:00
abstract：STUDY DESIGN:Prospective cohort study. OBJECTIVES:To study upper extremity musculoskeletal pain during and after rehabilitation in wheelchair-using subjects with a spinal cord injury (SCI) and its relation with lesion characteristics, muscle strength and functional outcome. SETTING:Eight rehabilitation centers with a...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101826
更新日期：2006-03-01 00:00:00
abstract：:We report a case of a 32-year old woman with radicular symptoms associated with a low cervical chordoma. According to our knowledge this is the 10th case of low cervical chordoma reported in the literature. ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.1996.65
更新日期：1996-06-01 00:00:00
abstract：STUDY DESIGN:Retrospective case-control. OBJECTIVES:To characterize changes in American Spinal Injury Association Motor Score (AMS) in patients treated with relative hypertension (HTN) (mean arterial pressure (MAP) > 85 mm Hg for 5 days) with and without preexisting HTN. SETTING:A regional spinal cord injury (SCI) ce...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.76
更新日期：2015-10-01 00:00:00
abstract：STUDY DESIGN:Experimental animal study. OBJECTIVE:The current study aims to test whether the blood flow within the contused spinal cord can be assessed in a rodent model via the acoustic window of the laminectomy utilizing transcutaneous ultrasound. SETTING:Department of Neurological Surgery, University of Washington...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-0415-9
更新日期：2020-06-01 00:00:00
abstract：STUDY DESIGN:Case report of two subjects. OBJECTIVE:Charcot joints of the spine as a cause of Autonomic Dysreflexia in spinal cord lesions. SETTING:Stoke Mandeville Hospital, UK. METHOD:Two patients with long standing spinal cord lesions developed symptoms of headaches and sweating associated with sitting up and tra...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101345
更新日期：2002-09-01 00:00:00
abstract：STUDY DESIGN:Descriptive study. OBJECTIVES:To describe the epidemiological features of spinal cord injury (SCI) following the 2015 earthquakes in Nepal. SETTING:Spinal Injury Rehabilitation Centre, Kavre, Nepal. METHODS:Data were collected from the medical records of all earthquake-related patients seen from 25 Apri...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.25
更新日期：2017-07-01 00:00:00
abstract：STUDY DESIGN:Exploratory qualitative. OBJECTIVES:The aim of this study was to describe the experiences of bowel and bladder dysfunction on social activities and relationships in people with spinal cord injury living in the community. SETTING:People living with spinal cord injury experiencing bowel and bladder dysfunc...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.19
更新日期：2017-07-01 00:00:00
abstract：STUDY DESIGN:A retrospective hospital-based study. OBJECTIVES:To describe the epidemiologic features of traumatic spinal cord injury (TSCI) in Anhui Province. SETTING:Two hospitals within Anhui Province, China. METHODS:We retrospectively reviewed the hospital records on all patients with TSCI, admitted between 1 Jan...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.92
更新日期：2013-01-01 00:00:00
abstract：:The purpose of this study was to examine ventilatory muscle strength as represented by static respiratory pressures in 30 tetraplegic patients with a complete lesion between the fifth and the eighth cervical vertebrae. The Inspiratory/Expiratory Pressure Meter was used to obtain maximum static expiratory mouth pressur...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100336
更新日期：1997-01-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional study using a consecutive sample. OBJECTIVES:To modify the Motor Assessment Scale (MAS) item 3 'balanced sitting' and the Sitting Balance Score (SBS) to ensure suitability for patients with spinal cord injury (SCI), and to assess the inter-rater reliability and validity of these instrument...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sc.2011.9
更新日期：2011-07-01 00:00:00
abstract：STUDY DESIGN:A case report of cervical myelopathy caused by epidural beta (2)-microglobulin (beta2m) amyloid deposits in a 50-year-old woman with haemodialysis treatment. OBJECTIVE:Long-term haemodialysis in patients with end-stage renal disease leads to several complications based on beta2m deposits, which can affect...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101969
更新日期：2007-04-01 00:00:00
abstract：STUDY DESIGN:Prospective. OBJECTIVES:To test whether provocative stimulation of the testes identifies men with chronic spinal cord injury (SCI), a population in which serum testosterone concentrations are often depressed, possibly due to gonadal dysfunction. To accomplish this objective, conventional and lower than th...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.8
更新日期：2017-07-01 00:00:00
abstract：STUDY DESIGN:Psychometric study. OBJECTIVES:Evaluate the intra-rater and inter-rater reliability of the Penn Spasm Frequency Scale (PSFS) in people with chronic traumatic spinal cord injury (SCI). SETTING:Community setting. METHODS:Participants with chronic traumatic SCI were administered the PSFS, a self-reported s...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0063-5
更新日期：2018-06-01 00:00:00
abstract：STUDY DESIGN:Two case reports of intramedullary teratoma in the spinal cord of adults, and a review of the literature. OBJECTIVE:To investigate and describe unusual cases of spinal teratoma using MRI to define features that may be used to avoid misdiagnosis. SETTING:A department of orthopedic surgery in Japan. METHO...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101247
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to develop the International Spinal Cord Injury (SCI) Endocrine and Metabolic Extended Data Set (ISCIEMEDS) within the framework of the International SCI Data Sets that would facilitate consistent collection and reporting of endocrine and metabolic findings in the SCI populatio...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.164
更新日期：2017-05-01 00:00:00
abstract：STUDY DESIGN:Case report and review of the literature. OBJECTIVE:To report an unusual case of a spinal intradural extramedullary cavernous angioma (CA), located at the cauda equina, and to compare it with the previously published 22 surgically treated cases in the literature. SETTING:Ankara, Turkey. METHOD:A 67-year...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101990
更新日期：2007-09-01 00:00:00
abstract：STUDY DESIGN:Retrospective. OBJECTIVES:To improve the use of bacteriological results for treating spinal cord-injured patients with infected pressure ulcers. SETTING:Microbiology and Orthopaedics Department, Ambroise Paré University Hospital, Boulogne-Billancourt, France. METHODS:Tissue specimens, sampled at the end...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101568
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:This study aims to understand the demographics, mode of trauma, hospital stay, complications, neurological improvement, mortality and expenditure incurred by Indian patients with spinal trauma and ankylosing spondylitis (AS). METHODS:Retrospective analysis of the patient data admitted to a tertiary referral ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.150
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:To draw attention to inadequate care received by some spinal cord injury patients after discharge from the regional spinal injury center. SETTING:Regional Spinal Injuries Centre, Southport, UK. METHODS:Presence of the urethral stricture was not recognised in a 69-year-old male with T-3 paraplegia, who atten...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101576
更新日期：2004-08-01 00:00:00
abstract：STUDY DESIGN:Retrospective cohort study. OBJECTIVES:To analyze magnetic resonance imaging (MRI) evaluator agreement in dogs with spinal cord injury (SCI) caused by intervertebral disk herniation (IVDH) using semiautomated and manual lesion segmentation and to analyze the associations between MRI and functional outcome...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.244
更新日期：2015-04-01 00:00:00
abstract：STUDY DESIGN:Inception cohort. OBJECTIVES:The clinical impression that earwax is uncommonly frequent among spinal cord injury patients with high levels of paralysis was tested. SETTING:Veterans Administration Hospital, USA. METHODS:A cohort of 15 chronically paralyzed patients, motor complete, living as residents in...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101444
更新日期：2003-04-01 00:00:00
abstract：STUDY DESIGN:Spinal cord injured rat model, treated with soluble complement receptor type 1 (sCR1). SETTING:Experimental Animal Department of China Medical University, Shenyang, China. OBJECTIVES:Soluble CR1 is a powerful inhibitor of complement activation. In this study, we investigate the effectiveness of sCR1 on s...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2009.104
更新日期：2010-02-01 00:00:00
abstract：STUDY DESIGN:Psychometric study using retrospectively collected data. OBJECTIVES:We investigated the comparability of quantitative computed tomography (qCT) in assessing bone mineral density (BMD) with dual energy X-ray absorptiometry (DXA). We evaluated how well previously suggested normal values for spinal Hounsfiel...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-017-0041-3
更新日期：2018-05-01 00:00:00
abstract：STUDY DESIGN:Prospective repeated measures. OBJECTIVES:Evaluate intra-rater agreement of repeated motor and sensory scores at individual spinal levels. SETTING:Non-profit pediatric rehabilitation center. METHODS:Fifty-eight youth with complete spinal cord injury undergoing two neurological exams. Agreement between e...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2008.66
更新日期：2009-01-01 00:00:00
abstract：STUDY DESIGN:Prospective cross-sectional multicenter study. OBJECTIVE:To evaluate the correlation, sensitivity, specificity and predictive values of S4-5 dermatome and the anorectal examination for determination of sacral sparing in the International Standards for Neurological Classification of Spinal Cord Injury (ISN...
journal_title：Spinal cord
pub_type： 杂志文章,多中心研究
doi：10.1038/sc.2010.144
更新日期：2011-03-01 00:00:00
abstract：:Spinal cord-injured (SCI) patients often suffer from symptomatic polymicrobial urinary tract infection (UTI). The objective of this study was to evaluate the clinical outcome and cost-savings associated with antibiotic therapy based on limited vs full microbiological investigation of urine cultures in adult SCI patien...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.sc.3100429
更新日期：1997-08-01 00:00:00
abstract：STUDY DESIGN:Prospective multicenter cohort study. OBJECTIVES:To compare the neurological recovery and functional outcomes between traumatic central cord syndrome (TCCS) patients and motor incomplete tetraplegic patients. SETTING:European Multicenter Study of human spinal cord injury. METHODS:In 248 traumatic motor ...
journal_title：Spinal cord
pub_type： 杂志文章,多中心研究
doi：10.1038/sc.2010.171
更新日期：2011-05-01 00:00:00
