Abstract:
OBJECTIVES:Latent inhibition (LI) refers to the retarding effects of inconsequential stimulus preexposure on subsequent conditioning to that stimulus, and reflects the organism's capacity to ignore irrelevant stimuli. LI is disrupted in schizophrenia patients, due to faster learning of the association between the conditioned stimulus (CS) and an unconditioned stimulus (US). It was recently proposed that LI has an additional pole of abnormality indicated by LI persistence. METHODS:Two experiments were performed to test this hypothesis. Both experiments applied a new within-subject, visual recognition LI procedure in which the association between a cue (CS) and the target (US) is acquired. In Exp 1 the task was applied to healthy volunteers (n=21). In Exp 2 chronic schizophrenia patients (n=19) were compared to control subjects (n=20). RESULTS:In Exp 1 the subjects showed LI in the initial trials of cue-target pairings, and an attenuation of the phenomenon at later trials. In Exp 2 control subjects showed a pattern of response comparable to the subjects of Exp 1, while the patients showed LI only on the later trials of the task. CONCLUSIONS:This result suggests that patients with chronic schizophrenia showed LI persistence. The possible advantages of the new LI paradigm are discussed.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Gal G,Barnea Y,Biran L,Mendlovic S,Gedi T,Halavy M,Feldon J,Fennig S,Levkovitz Ydoi
10.1016/j.bbr.2008.08.023subject
Has Abstractpub_date
2009-01-30 00:00:00pages
1-8issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00471-3journal_volume
197pub_type
杂志文章abstract::In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)02261-9
更新日期:1997-07-01 00:00:00
abstract::The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor block...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.12.033
更新日期:2011-06-01 00:00:00
abstract::Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. The aim of the present study was to propose a model to explain how critical factors determine ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.01.012
更新日期:2008-06-03 00:00:00
abstract::There is emerging evidence for a dopamine (DA)-serotonin (5-HT) interaction underlying obsessive-compulsive disorder (OCD). In the quinpirole sensitization rat model of OCD, compulsive checking is induced by chronic treatment with the DA agonist quinpirole, and is attenuated by the 5-HT agonist drug mCPP. However, mCP...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.11.017
更新日期:2015-02-15 00:00:00
abstract::Sleep and waking stages in cats were studied 8 h following administration of zimeldine and alaproclate, in combination with saline or 5-hydroxy-1-tryptophan (5-HTP). Both drugs in combination with saline reduced rapid eye movement sleep and ponto-geniculo-occipital wave activity, and the effects were potentiated with ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(87)90031-3
更新日期:1987-04-01 00:00:00
abstract::Stress elicits relapse to cocaine seeking in humans and in animal models. Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. However, the role of CREB in other stress-induced reinstatement models has not been examined. To determ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.02.026
更新日期:2013-06-01 00:00:00
abstract::Value-based action selection has been suggested to be realized in the corticostriatal local circuits through competition among neural populations. In this article, we review theoretical and experimental studies that have constructed and verified this notion, and provide new perspectives on how the local-circuit select...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2016.05.017
更新日期:2016-09-15 00:00:00
abstract::The role of forebrain catecholamine systems in spatial learning was assessed using a recently described place navigation task. Rats were required to learn the spatial location of a platform hidden 1 cm below the surface in order to escape from a large pool filled with opaque water. Circumscribed destruction of dopamin...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90015-3
更新日期:1983-07-01 00:00:00
abstract::Conditioned tolerance can be conceptualized as a particular case of Pavlovian conditioning in which contextual cues play the role of the conditioned stimulus. Although the evidence is contradictory, it is frequently assumed that long-term contextual conditioning in pre-weanling rats is weak or even absent. This hypoth...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.06.007
更新日期:2017-08-14 00:00:00
abstract::Animals reared in an enriched environment are less vulnerable to abuse-like behavior and exhibit less persistent drug seeking, perhaps due to a decrease in the incentive value of stimuli associated with reward. The present study investigated the effects of environmental enrichment on Pavlovian conditioned approach (PC...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.09.021
更新日期:2012-01-01 00:00:00
abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on four sessions of instrumental avoidance conditioning, during which an eyeblink (EB) response during the presentation of a tone-conditioned stimulus prevented the occurrence of a paraor...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90103-1
更新日期:1994-12-15 00:00:00
abstract::Panic attacks present a high comorbidity with agoraphobia, separation anxiety and generalized anxiety disorder. Nevertheless, while panic attacks have been frequently equated to fear, the relationship of panic disorder with specific phobias remains uncertain. The combination of experimental models of panic and phobias...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.11.042
更新日期:2009-05-16 00:00:00
abstract::Involvement of the medial septal area (MSA) in consolidation and retrieval of passive avoidance response (PAR) was investigated with functional suppression of this area by tetrodotoxin (TTX). Rats carrying a chronically implanted cannula aimed at the MSA were trained on a step-through passive avoidance task and receiv...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(96)00136-2
更新日期:1995-12-14 00:00:00
abstract::COR659 is a recently synthesized positive allosteric modulator (PAM) of the GABAB receptor. Similarly to all GABAB PAMs tested to date, COR659 has been reported to suppress different alcohol-related behaviors in rodents. The present study was designed to assess whether the anti-addictive properties of COR659 extend to...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.113045
更新日期:2021-02-26 00:00:00
abstract::Spinal trigeminal nucleus pars oralis (SpoV) is anatomically linked to brain circuitry thought to subserve unconditioned and conditioned nictitating membrane responses in rabbit. Single-unit recording from SpoV and adjacent reticular formation obtained during conditioning from awake, behaving animals revealed modulati...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80024-5
更新日期:1991-08-29 00:00:00
abstract::Esthetic experience is a unique, affectively colored, self-transcending subject-object relationship in which cognitive processing is felt to flow differently than during everyday experiences. Notwithstanding previous multidisciplinary investigations, how esthetic experience modulates perception is still obscure. We us...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.09.041
更新日期:2015-02-01 00:00:00
abstract::We investigated the role of dopaminergic mechanisms in the attenuation of the acoustic startle response and prepulse inhibition (PPI) in rats by the introduction of unexpected changes in environment illumination. Experiment 1 showed that Dark-to-Light transitions robustly reduce startle responses and PPI. Experiment 2...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.08.030
更新日期:2009-02-11 00:00:00
abstract::Long-term memory of active avoidance in mice is not disturbed by administration of protein synthesis inhibitors (PSIs) when relatively high levels of training are used, whereas a detrimental effect is produced with lower levels of training. PSIs also disrupt extinction of avoidance behaviors in rodents, but it is not ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.03.031
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehic...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.10.032
更新日期:2015-02-01 00:00:00
abstract::The thalamofugal visual projections of the chick are known to develop in response to stimulation by light prior to hatching, and asymmetry in the number of projections develops as a consequence of the embryo being oriented in the egg so that it occuludes its left eye. The right eye only is stimulated by light and this...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(96)00021-6
更新日期:1996-10-01 00:00:00
abstract::A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate t...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2009.03.004
更新日期:2009-08-12 00:00:00
abstract::We related fiber trajectory through the feline corpus callosum to the site of fiber origin in the cortical mantle and to functional modality. The cortical fields which contribute axons to the different portions of the corpus callosum were revealed by applying horseradish peroxidase (HRP) to the cut ends of selected gr...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90116-3
更新日期:1994-10-20 00:00:00
abstract::Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This re...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.07.039
更新日期:2018-10-15 00:00:00
abstract::The study examined the effect of testosterone on the asymmetry of visual discrimination performance of young chicks. Two-week-old chicks were tested on the pebble floor visual discrimination task. Male chicks were found to have brain asymmetry for visual discrimination learning, since chicks tested binocularly, or tes...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(87)90026-x
更新日期:1987-03-01 00:00:00
abstract::Norepinephrine (NE) is involved in a variety of behaviors across vertebrate species. In songbirds, NE is involved in singing and auditory perception, fundamental components of pair formation. Mechanisms of pairing remain poorly understood in avian species. NE is likely involved given its role in vocal communication an...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.05.056
更新日期:2013-09-01 00:00:00
abstract::The hypothalamus is a center of convergence and integration of multiple nutrient-related signals. It can sense changes in circulating adiposity hormones, gastric hormones and nutrients, and receives neuroanatomical projections from other nutrient sensors, mainly within the brainstem. The hypothalamus also integrates t...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2009.12.024
更新日期:2010-05-01 00:00:00
abstract::Autism spectrum disorders (ASDs) are neuropsychiatric disorders associated with synaptic function and plasticity. Neural cell adhesion molecule (NCAM1) dysfunction impairs synapse formation, synaptic activity and plasticity. To explore the relationship between NCAM1 and ASD, a case-control study was conducted. This re...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.11.012
更新日期:2019-02-01 00:00:00
abstract::This study aims to investigate the octopus' eye and arm coordination and raises the question if visual guidance determines choice of arm use. Octopuses possess eight seemingly identical arms but have recently been reported to show a preference as to which arm they use to initiate contact with objects. These animals al...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.04.026
更新日期:2006-09-25 00:00:00
abstract::This report summarizes 4 experiments which deal with the effects of surgical removal of the rat's telencephalic forebrain structures on performance of an inhibitory avoidance response, which was acquired either before or after the lesion was made. Two experiments provide evidence that inhibitory avoidance learning (us...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(86)90036-7
更新日期:1986-11-01 00:00:00
abstract:INTRODUCTION:Neuroticism is a complex personality trait encompassing diverse aspects. Notably, high levels of neuroticism are related to the onset of psychiatric conditions, including anxiety and mood disorders. Personality traits are stable individual features; therefore, they can be expected to be associated with sta...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.03.031
更新日期:2017-06-01 00:00:00