Abstract：
BACKGROUND:Depression and depressive symptoms have been repeatedly linked to elevated levels of C-reactive protein (CRP) but questions remain as to the statistical robustness of the association and particularly whether the association between depression and CRP reflects the presence of a chronic disease. METHODS:A random sample of 6,126 men and women aged 45-69 years was examined in a cross-sectional study in seven towns in the Czech Republic. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CESD) scale. RESULTS:Center for Epidemiologic Studies Depression score was significantly related to increased levels of CRP in a linear fashion. After controlling for a range of potential confounders, subjects with depressive symptoms (CESD score >or= 16) had CRP concentrations 0.43 mg/l (95% CI 0.16-0.72) higher than those without symptoms. The association remained significant when study sample was restricted to healthy subjects; among individuals who did not report any chronic disease, the difference between those with and without depressive symptoms was 0.44 mg/l (95% CI 0.14-0.74), and among persons who did not visit a doctor in the last 12 months the difference was 1.20 mg/l (95% CI 0.52-1.87). CONCLUSIONS:These results confirm that there is a statistically robust association between depressive symptoms and increased levels of CRP. We did not find evidence that the association is due presence of a chronic condition.
journal_name
Soc Psychiatry Psychiatr Epidemioljournal_title
Social psychiatry and psychiatric epidemiologyauthors
Pikhart H,Hubacek JA,Kubinova R,Nicholson A,Peasey A,Capkova N,Poledne R,Bobak Mdoi
10.1007/s00127-008-0422-1subject
Has Abstractpub_date
2009-03-01 00:00:00pages
217-22issue
3eissn
0933-7954issn
1433-9285journal_volume
44pub_type
杂志文章abstract：PURPOSE:Maccabi Healthcare Services, a large health maintenance organization (HMO) operating in Israel, has recently constructed a computerized registry of patients with severe mental illnesses (SMI). In the present study, we aimed to use this registry to investigate the epidemiology of schizophrenia and bipolar affect...
journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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journal_title：Social psychiatry and psychiatric epidemiology
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更新日期：2011-01-01 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：Social psychiatry and psychiatric epidemiology
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更新日期：2010-05-01 00:00:00
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更新日期：2008-04-01 00:00:00
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journal_title：Social psychiatry and psychiatric epidemiology
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更新日期：2011-02-01 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Social psychiatry and psychiatric epidemiology
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更新日期：2012-08-01 00:00:00
