Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.

abstract：:Yju2 is an essential splicing factor required for the first catalytic step after the action of Prp2. We dissected the structure of Yju2 and found that the amino (Yju2-N) and carboxyl (Yju2-C) halves of the protein can be separated and reconstituted for Yju2 function both in vivo and in vitro. Yju2-N has a weak affinit...

journal_title：Molecular and cellular biology

authors： Chiang TW,Cheng SC

更新日期：2013-05-01 00:00:00

abstract：:Introduction of simian virus 40 T antigen into rodent fibroblasts gives rise to cells that can proliferate indefinitely but are dependent upon it for maintenance of their growth once the normal mitotic life span has elapsed. Inactivation of T antigen in these immortalized cells causes rapid and irreversible cessation ...

journal_title：Molecular and cellular biology

authors： Gonos ES,Burns JS,Mazars GR,Kobrna A,Riley TE,Barnett SC,Zafarana G,Ludwig RL,Ikram Z,Powell AJ,Jat PS

更新日期：1996-09-01 00:00:00

abstract：:Smad6 and Smad7 are inhibitory Smads induced by transforming growth factor beta-Smad signal transduction pathways in a negative-feedback mechanism. Previously it has been thought that inhibitory Smads bind to the type I receptor and block the phosphorylation of receptor-activated Smads, thereby inhibiting the initiati...

journal_title：Molecular and cellular biology

authors： Lin X,Liang YY,Sun B,Liang M,Shi Y,Brunicardi FC,Shi Y,Feng XH

更新日期：2003-12-01 00:00:00

abstract：:The chaperone-related AAA ATPase Cdc48 (p97/VCP in higher eukaryotes) segregates ubiquitylated proteins for subsequent degradation by the 26S proteasome or for nonproteolytic fates. The specific outcome of Cdc48 activity is controlled by the evolutionary conserved cofactors Ufd2 and Ufd3, which antagonistically regula...

journal_title：Molecular and cellular biology

authors： Böhm S,Lamberti G,Fernández-Sáiz V,Stapf C,Buchberger A

更新日期：2011-04-01 00:00:00

abstract：:For proper male sexual differentiation, anti-Müllerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Müllerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic...

journal_title：Molecular and cellular biology

authors： De Santa Barbara P,Bonneaud N,Boizet B,Desclozeaux M,Moniot B,Sudbeck P,Scherer G,Poulat F,Berta P

更新日期：1998-11-01 00:00:00

abstract：:The Saccharomyces cerevisiae mutant ref2-1 (REF = RNA end formation) was originally identified by a genetic strategy predicted to detect decreases in the use of a CYC1 poly(A) site interposed within the intron of an ACT1-HIS4 fusion reporter gene. Direct RNA analysis now proves this effect and also demonstrates the tr...

journal_title：Molecular and cellular biology

authors： Russnak R,Nehrke KW,Platt T

更新日期：1995-03-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J. Biol. Chem. 279:12051-12059, 2004). Here, we demonstrate a novel role for integrin...

journal_title：Molecular and cellular biology

authors： Leung-Hagesteijn C,Hu MC,Mahendra AS,Hartwig S,Klamut HJ,Rosenblum ND,Hannigan GE

更新日期：2005-05-01 00:00:00

abstract：:Akt is activated on the plasma membrane and its substrates are distributed throughout various cellular compartments. To phosphorylate its substrates, Akt needs to be recruited to specific intracellular compartments. Thus, regulation of Akt cellular compartmentalization constitutes an important mechanism to specify Akt...

journal_title：Molecular and cellular biology

authors： Ding J,Du K

更新日期：2009-03-01 00:00:00

abstract：:Somatic cell nuclear cloning has repeatedly demonstrated striking reversibility of epigenetic regulation of cell differentiation. Upon injection into eggs, the donor nuclei exhibit global chromatin decondensation, which might contribute to reprogramming the nuclei by derepressing dormant genes. Decondensation of sperm...

journal_title：Molecular and cellular biology

authors： Tamada H,Van Thuan N,Reed P,Nelson D,Katoku-Kikyo N,Wudel J,Wakayama T,Kikyo N

更新日期：2006-02-01 00:00:00

abstract：:A DNA sequence encoding the A chain of ricin toxin (RTA) from the castor bean plant, Ricinus communis, was placed under GAL1 promoter control and transformed into Saccharomyces cerevisiae. Induction of expression of RTA was lethal. This lethality was the basis for a selection of mutations in RTA which inactivated the ...

journal_title：Molecular and cellular biology

authors： Frankel A,Schlossman D,Welsh P,Hertler A,Withers D,Johnston S

更新日期：1989-02-01 00:00:00

abstract：:Transcriptional insulators are cis regulatory elements that organize chromatin into independently regulated domains. At the imprinted murine Igf2/H19 locus, the H19-ICR insulator prevents the activation of the Igf2 promoter on the maternal allele by enhancers that activate H19 on the same chromosome. Given the well-de...

journal_title：Molecular and cellular biology

authors： Singh V,Srivastava M

更新日期：2008-06-01 00:00:00

abstract：:The expressed variant cell surface glycoprotein (VSG) gene of the protozoan parasite Trypanosoma brucei is invariably found at one of several telomeric VSG gene expression sites (ESs). The active ES in variant 118 clone 1 is found on a 1.5-Mb chromosome, and the promoter region is located more than 45 kb upstream of t...

journal_title：Molecular and cellular biology

authors： Gottesdiener KM,Goriparthi L,Masucci JP,Van der Ploeg LH

更新日期：1992-10-01 00:00:00

abstract：:Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a technique using a degenerate phosphopeptide library to predict the specificity of individual SH2 domains (src family members, Abl, Nck, Sem5, ph...

journal_title：Molecular and cellular biology

authors： Songyang Z,Shoelson SE,McGlade J,Olivier P,Pawson T,Bustelo XR,Barbacid M,Sabe H,Hanafusa H,Yi T

更新日期：1994-04-01 00:00:00

abstract：:Chromatin is regulated by cross talk among different histone modifications, which can occur between residues within the same tail or different tails in the nucleosome. The latter is referred to as trans-tail regulation, and the best-characterized example of this is the dependence of H3 methylation on H2B ubiquitylatio...

journal_title：Molecular and cellular biology

authors： Zheng S,Wyrick JJ,Reese JC

更新日期：2010-07-01 00:00:00

abstract：:The ARK (AXL, UFO) receptor is a member of a new family of receptor tyrosine kinases whose extracellular domain contains a combination of fibronectin type III and immunoglobulin motifs similar to those found in many cell adhesion molecules. ARK mRNA is expressed at high levels in the mouse brain, prevalently in the hi...

journal_title：Molecular and cellular biology

authors： Bellosta P,Costa M,Lin DA,Basilico C

更新日期：1995-02-01 00:00:00

abstract：:Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1...

journal_title：Molecular and cellular biology

authors： Meriin AB,Yaglom JA,Gabai VL,Zon L,Ganiatsas S,Mosser DD,Zon L,Sherman MY

更新日期：1999-04-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses is likely in the unusual class of glycoproteins with the amino terminus cytoplasmic and the carboxy terminus lumenal or external to the cell. The properties of the membrane insertion of the HN protein of Newcastle disease virus, a prototype paramyxovirus,...

journal_title：Molecular and cellular biology

authors： Wilson C,Gilmore R,Morrison T

更新日期：1987-04-01 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signalin...

journal_title：Molecular and cellular biology

authors： Cristóbal I,Rojo F,Madoz-Gúrpide J,García-Foncillas J

更新日期：2016-05-31 00:00:00

abstract：:Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and...

journal_title：Molecular and cellular biology

authors： Leu JI,Crissey MA,Leu JP,Ciliberto G,Taub R

更新日期：2001-01-01 00:00:00

abstract：:Our current knowledge of recombination hot spot activity in mammalian systems implicates a role for both the primary DNA sequence and the nature of the chromatin domain around it. In mice, the only recombination hot spots mapped to date have been confined to a cluster within the major histocompatibility complex (MHC) ...

journal_title：Molecular and cellular biology

authors： Nishant KT,Ravishankar H,Rao MR

更新日期：2004-06-01 00:00:00

abstract：:Signaling downstream of mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) controls specific and distinct aspects of insulin action and nutrient homeostasis in an interconnected and as yet unclear way. Mice lacking the mTORC1 substrate S6 kinase 1 (S6K1) maintain proper glycemic control with a high-...

journal_title：Molecular and cellular biology

authors： Treins C,Alliouachene S,Hassouna R,Xie Y,Birnbaum MJ,Pende M

更新日期：2012-10-01 00:00:00

abstract：:A transcriptional initiator (Inr) for mammalian RNA polymerase II can be defined as a DNA sequence element that overlaps a transcription start site and is sufficient for (i) determining the start site location in a promoter that lacks a TATA box and (ii) enhancing the strength of a promoter that contains a TATA box. W...

journal_title：Molecular and cellular biology

authors： Javahery R,Khachi A,Lo K,Zenzie-Gregory B,Smale ST

更新日期：1994-01-01 00:00:00

abstract：:ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors. Retinoic acid receptor (RAR) activators (all-trans-retinoic acid [ATRA] and TTNPB) were found to increase ATP-binding cassette trans...

journal_title：Molecular and cellular biology

authors： Costet P,Lalanne F,Gerbod-Giannone MC,Molina JR,Fu X,Lund EG,Gudas LJ,Tall AR

更新日期：2003-11-01 00:00:00

abstract：:The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart failure and prematur...

journal_title：Molecular and cellular biology

authors： Princen F,Bard E,Sheikh F,Zhang SS,Wang J,Zago WM,Wu D,Trelles RD,Bailly-Maitre B,Kahn CR,Chen Y,Reed JC,Tong GG,Mercola M,Chen J,Feng GS

更新日期：2009-01-01 00:00:00

abstract：:Autophagy is considered an adaptive mechanism against hyperosmotic stress. Although the process has been reported to be triggered by the inhibition of mTORC1, the precise downstream mechanisms remain elusive. Here, we demonstrate that hyperosmotic-stress-induced autophagy is different from conventional macroautophagy ...

journal_title：Molecular and cellular biology

authors： Tamura N,Kageyama S,Komatsu M,Waguri S

更新日期：2019-07-29 00:00:00

abstract：:Malignant melanoma, an aggressive and increasingly common cancer, is characterized by a strikingly high rate (70%) of mutations in BRAF, a key component of the mitogen-activated protein (MAP) kinase signaling pathway. How signaling events downstream from BRAF affect the underlying program of gene expression is poorly ...

journal_title：Molecular and cellular biology

authors： Goodall J,Wellbrock C,Dexter TJ,Roberts K,Marais R,Goding CR

更新日期：2004-04-01 00:00:00

abstract：:Although the splicing of transcripts from most eukaryotic genes occurs in a constitutive fashion, some genes can undergo a process of alternative splicing. This is a genetically economical process which allows a single gene to give rise to several protein isoforms by the inclusion or exclusion of sequences into or fro...

journal_title：Molecular and cellular biology

authors： Bell MV,Cowper AE,Lefranc MP,Bell JI,Screaton GR

更新日期：1998-10-01 00:00:00

abstract：:We have determined the effects of a number of mutations in the small-t antigen mRNA intron on the alternative splicing pattern of the simian virus 40 early transcript. Expansion of the distance separating the small-t pre-mRNA lariat branch point and the shared large T-small t 3' splice site from 18 to 29 nucleotides (...

journal_title：Molecular and cellular biology

authors： Fu XY,Colgan JD,Manley JL

更新日期：1988-09-01 00:00:00

abstract：:Using nuclear runoff transcription assays we demonstrated that alpha interferon-mediated induction of transcription of four mRNAs in HeLa monolayer cells needed ongoing protein synthesis and that such a need could be obviated by pretreating the cells with gamma interferon which, by itself, did not induce transcription...

journal_title：Molecular and cellular biology

authors： Kusari J,Sen GC

更新日期：1987-01-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from the t(2;5) translocation that is frequently associated with anaplastic large-cell lymphomas. The native ALK protein is normally expressed in the developing and, at a weaker level, ...

journal_title：Molecular and cellular biology

authors： Mourali J,Bénard A,Lourenço FC,Monnet C,Greenland C,Moog-Lutz C,Racaud-Sultan C,Gonzalez-Dunia D,Vigny M,Mehlen P,Delsol G,Allouche M

更新日期：2006-08-01 00:00:00